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学科主题: 临床医学
题名:
Accuracy of MR elastography and anatomic MR imaging features in the diagnosis of severe hepatic fibrosis and cirrhosis
作者: Rustogi, Rahul1; Horowitz, Jeanne1; Harmath, Carla1; Wang, Yi1,2; Chalian, Hamid1; Ganger, Daniel R.3; Chen, Zongming E.4; Bolster, Bradley D., Jr.5; Shah, Saurabh6; Miller, Frank H.1
关键词: liver ; fibrosis ; cirrhosis ; magnetic resonance elastography ; morphological features
刊名: JOURNAL OF MAGNETIC RESONANCE IMAGING
发表日期: 2012-06-01
DOI: 10.1002/jmri.23585
卷: 35, 期:6, 页:1356-1364
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: MAGNETIC-RESONANCE ELASTOGRAPHY ; RIGHT LOBE RATIO ; LIVER FIBROSIS ; NONINVASIVE ASSESSMENT ; COMPUTED-TOMOGRAPHY ; MORPHOLOGY ; CAUDATE ; DISEASE ; BIOPSY ; SIGN
英文摘要:

Purpose: To compare the diagnostic accuracy of magnetic resonance imaging elastography (MRE) and anatomic MRI features in the diagnosis of severe hepatic fibrosis and cirrhosis. Materials and Methods: Three readers independently assessed presence of morphological changes associated with hepatic fibrosis in 72 patients with liver biopsy including: caudate to right lobe ratios, nodularity, portal venous hypertension (PVH) stigmata, posterior hepatic notch, expanded gallbladder fossa, and right hepatic vein caliber. Three readers measured shear stiffness values using quantitative shear stiffness maps (elastograms). Sensitivity, specificity, and diagnostic accuracy of stiffness values and each morphological feature were calculated. Interreader agreement was summarized using weighted kappa statistics. Intraclass correlation coefficient was used to assess interreader reproducibility of stiffness measurements. Binary logistic regression was used to assess interreader variability for dichotomized stiffness values and each morphological feature. Results: Using 5.9 kPa as a cutoff for differentiating F3-F4 from F0-2 stages, overall sensitivity, specificity, and diagnostic accuracy for MRE were 85.4%, 88.4%, and 87%, respectively. Overall interreader agreement for stiffness values was substantial, with an insignificant difference (P = 0.74) in the frequency of differentiating F3-4 from F0-2 fibrosis. Only hepatic nodularity and PVH stigmata showed moderately high overall accuracy of 69.4% and 72.2%. Interreader agreement was substantial only for PVH stigmata, moderate for C/R m, deep notch, and expanded gallbladder fossa. Only posterior hepatic notch (P = 0.82) showed no significant difference in reader rating. Conclusion: MRE is a noninvasive, accurate, and reproducible technique compared with conventional features of detecting severe hepatic fibrosis. J. Magn. Reson. Imaging 2012;. (c) 2012 Wiley Periodicals, Inc.

语种: 英语
所属项目编号: EB001981
项目资助者: National Institutes of Health
WOS记录号: WOS:000304035100012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54617
Appears in Collections:北京大学第二临床医学院_放射科_期刊论文

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作者单位: 1.Siemens Healthcare, Rochester, MN USA
2.Siemens Healthcare, Chicago, IL USA
3.Northwestern Univ, Dept Radiol, Feinberg Sch Med, NW Mem Hosp, Chicago, IL 60611 USA
4.Beijing Univ, Peoples Hosp, Dept Radiol, Beijing 100871, Peoples R China
5.Northwestern Univ, Feinberg Sch Med, Dept Med, NW Mem Hosp,Hepatol Div, Chicago, IL 60611 USA
6.Northwestern Univ, NW Mem Hosp, Feinberg Sch Med, Dept Pathol, Chicago, IL 60611 USA

Recommended Citation:
Rustogi, Rahul,Horowitz, Jeanne,Harmath, Carla,et al. Accuracy of MR elastography and anatomic MR imaging features in the diagnosis of severe hepatic fibrosis and cirrhosis[J]. JOURNAL OF MAGNETIC RESONANCE IMAGING,2012,35(6):1356-1364.
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