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Lack of association between HLA-A, -B and-DRB1 alleles and the development of SARS: a cohort of 95 SARS-recovered individuals in a population of Guangdong, southern China
Xiong, P.2; Zeng, X.3; Song, M. S.1,6; Jia, S. W.4; Zhong, M. H.2; Xiao, L. L.5; Lan, W.; Cai, C.3; Wu, X. W.2; Gong, F. L.2; Wang, W.1,6
刊名INTERNATIONAL JOURNAL OF IMMUNOGENETICS
2008-02-01
DOI10.1111/j.1744-313X.2007.00741.x
35期:1页:69-74
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity ; Immunology
研究领域[WOS]Genetics & Heredity ; Immunology
关键词[WOS]ACUTE RESPIRATORY SYNDROME ; ANTIGEN CLASS-I ; VIETNAMESE POPULATION ; POLYMORPHISMS ; CORONAVIRUS ; GENES ; SUSCEPTIBILITY ; FREQUENCIES ; RESISTANCE ; INFECTION
英文摘要

Severe acute respiratory syndrome (SARS), caused by infection with a novel coronavirus (SARS-CoV), was the first major novel infectious disease at the beginning of the 21st century, with China especially affected. SARS was characterized by high infectivity, morbidity and mortality, and the confined pattern of the disease spreading among the countries of South-East and East Asia suggested the existence of susceptible factor(s) in these populations. Studies in the populations of Hong Kong and Taiwan showed an association of human leucocyte antigen (HLA) polymorphisms with the development and/or severity of SARS, respectively. The aim of the present study was to define the genotypic patterns of HLA-A, -B and -DRB1 loci in SARS patients and a co-resident population of Guangdong province, southern China, where the first SARS case was reported. The samples comprised 95 cases of recovered SARS patients and 403 unrelated healthy controls. HLA -A, -B and -DRB1 alleles were genotyped using polymerase chain reaction with sequence-specific primers. The severity of the disease was assessed according to the history of lung infiltration, usage of assisted ventilation and occurrence of lymphocytopenia. Although the allelic frequencies of A23, A34, B60, DRB1*12 in the SARS group were slightly higher, and A33, -B58 and -B61 were lower than in the controls, no statistical significance was found when the Pc value was considered. Similarly, no association of HLA alleles with the severity of the disease was detected. Thus, variations in the major histocompatibility complex are unlikely to have contributed significantly to either the susceptibility or the severity of SARS in the population of Guangdong.

语种英语
WOS记录号WOS:000252120400012
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54618
专题北京大学深圳医院
作者单位1.Guangdong Prov TCM Hosp, Guangzhou, Peoples R China
2.Peking Univ, Shenzhen Hosp, Shenzhen, Peoples R China
3.Chinese Acad Sci, Grad Sch, Coll Life Sci, Dept Biol, Beijing 100049, Peoples R China
4.Huazhong Univ Sci & Technol, Tongji Med Coll, Wuhan 430074, Peoples R China
5.Sun Yat Sen Univ, Tissue Typing Ctr, Guangzhou, Peoples R China
6.Capital Med Univ, Sch Publ Hlth & Family Med, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Xiong, P.,Zeng, X.,Song, M. S.,et al. Lack of association between HLA-A, -B and-DRB1 alleles and the development of SARS: a cohort of 95 SARS-recovered individuals in a population of Guangdong, southern China[J]. INTERNATIONAL JOURNAL OF IMMUNOGENETICS,2008,35(1):69-74.
APA Xiong, P..,Zeng, X..,Song, M. S..,Jia, S. W..,Zhong, M. H..,...&Wang, W..(2008).Lack of association between HLA-A, -B and-DRB1 alleles and the development of SARS: a cohort of 95 SARS-recovered individuals in a population of Guangdong, southern China.INTERNATIONAL JOURNAL OF IMMUNOGENETICS,35(1),69-74.
MLA Xiong, P.,et al."Lack of association between HLA-A, -B and-DRB1 alleles and the development of SARS: a cohort of 95 SARS-recovered individuals in a population of Guangdong, southern China".INTERNATIONAL JOURNAL OF IMMUNOGENETICS 35.1(2008):69-74.
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