|Epidemiology of severe sepsis in critically ill surgical patients in ten university hospitals in China|
|Cheng, Baoli; Xie, Guohao; Yao, ShangLong; Wu, Xinmin; Guo, Qulian; Gu, Miaoning; Fang, Qiang; Xu, Qiuping; Wang, Dongxin; Jin, Yuhong; Yuan, ShiYing; Wang, Junlu; Du, Zhaohui; Sun, Yunbo; Fang, XiangMing|
|关键词||Epidemiology Severe Sepsis Critically Ill Surgical Patients Multicenter Study|
|刊名||CRITICAL CARE MEDICINE|
|WOS标题词||Science & Technology|
|类目[WOS]||Critical Care Medicine|
|研究领域[WOS]||General & Internal Medicine|
|关键词[WOS]||INTENSIVE-CARE UNITS ; ORGAN FAILURE ; MULTICENTER ; DEFINITIONS ; INFECTION ; SYSTEM ; STATES ; SCORE|
Objectives: To determine the occurrence rate, outcomes, and the characteristics of severe sepsis in surgical intensive care units in multiple medical centers within China and to assess the cost and resource use of severe sepsis in China.
Design and Setting: Prospective, observational study of surgical intensive care unit patients at ten university hospitals in six provinces in China.
Patients: All adult admissions in studied intensive care units from December 1, 2004, to November 30, 2005.
Measurements and Main Results. The criteria of severe sepsis were based on the American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference definition. Analysis of data from 3,665 intensive care unit admissions identified 318 (8.68%) cases of severe sepsis, 64.8% of which were men. The median age (interquartile range) of patients with severe sepsis was 64 (47-74) yrs. Microbes had been isolated from 228 (71.7%) patients, including 171 (53.8%) with Gram-negative bacteria and 146 (45.9%) with Gram-positive bacteria. A total of 90 (22.0%) patients had invasive fungal infection, 20 (6.3%) of which had fungemia. The abdomen was the most common site of infections (72.3%), followed by lung (52.8%). The overall hospital mortality of severe sepsis was 48.7%. Risk factors for hospital mortality included age, chronic comorbidity of malignant neoplasm, Gram-positive bacterial infection, invasive fungal infection, admission Acute Physiology Score, and admission Sequential Organ Failure Assessment score of respiratory dysfunction and cardiovascular dysfunction. The median Therapeutic Intervention Scoring System-28 score was 43 (38-49). The mean hospital cost was $11,390 per patient and $502 per patient per day.
Conclusions, Severe sepsis is a common, expensive, and frequently fatal syndrome in critically ill surgical patients in China. Other than the microbiological patterns, the incidence, mortality, and major characteristics of severe sepsis in Chinese surgical intensive care units are close to those documented in developed countries.
|作者单位||1.Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Anesthesiol Crit Care Unit, Hangzhou, Peoples R China|
2.Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Anesthesiol & Intens Care Unit, Wuhan 430074, Peoples R China
3.Peking Univ, Sch Med, Affiliated Hosp 1, Dept Anesthesiol & Intens Care Unit, Beijing, Peoples R China
4.Cent S Univ, Xiangya Med Coll, Xiangya Hosp, Dept Anesthesiol & Intens Care Unit, Changsha, Peoples R China
5.S Med Univ, S Hosp, Dept Anesthesiol & Intens Care Unit, Guangzhou, Guangdong, Peoples R China
6.Zhejiang Univ, Sch Med, Sir Run Run Shaw Hosp, Intens Care Unit, Hangzhou 310027, Peoples R China
7.Ningbo Univ, Sch Med, Lihuili Hosp, Intens Care Unit, Ningbo, Peoples R China
8.Wuhan Univ, Sch Med, Zhongnan Hosp, Intens Care Unit, Wuhan, Peoples R China
9.Wenzhou Med Coll, Affiliated Hosp 1, Dept Anesthesiol, Wenzhou, Peoples R China
10.Qingdao Univ Hosp, Sch Med, Dept Anesthesiol, Intens Care Unit, Qingdao, Peoples R China
|Cheng, Baoli,Xie, Guohao,Yao, ShangLong,et al. Epidemiology of severe sepsis in critically ill surgical patients in ten university hospitals in China[J]. CRITICAL CARE MEDICINE,2007,35(11):2538-2546.|
|APA||Cheng, Baoli.,Xie, Guohao.,Yao, ShangLong.,Wu, Xinmin.,Guo, Qulian.,...&Fang, XiangMing.(2007).Epidemiology of severe sepsis in critically ill surgical patients in ten university hospitals in China.CRITICAL CARE MEDICINE,35(11),2538-2546.|
|MLA||Cheng, Baoli,et al."Epidemiology of severe sepsis in critically ill surgical patients in ten university hospitals in China".CRITICAL CARE MEDICINE 35.11(2007):2538-2546.|