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Stress during a Critical Postnatal Period Induces Region-Specific Structural Abnormalities and Dysfunction of the Prefrontal Cortex via CRF1
Yang, Xiao-Dun1,2; Liao, Xue-Mei1,2; Uribe-Marino, Andres3; Liu, Rui1,2; Xie, Xiao-Meng1,2; Jia, Jiao4; Su, Yun-Ai1,2; Li, Ji-Tao1,2; Schmidt, Mathias V.3; Wang, Xiao-Dong5; Si, Tian-Mei1,2
刊名NEUROPSYCHOPHARMACOLOGY
2015-04-01
DOI10.1038/npp.2014.304
40期:5页:1203-1215
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]EARLY-LIFE STRESS ; CORTICOTROPIN-RELEASING-FACTOR ; DEVELOPMENTAL TIME WINDOWS ; V PYRAMIDAL NEURONS ; HORMONE-RECEPTOR 1 ; SYNAPTIC PLASTICITY ; DENDRITIC SPINES ; WORKING-MEMORY ; RAT ; PROJECTIONS
英文摘要

During the early postnatal period, environmental influences play a pivotal role in shaping the development of the neocortex, including the prefrontal cortex (PFC) that is crucial for working memory and goal-directed actions. Exposure to stressful experiences during this critical period may disrupt the development of PFC pyramidal neurons and impair the wiring and function of related neural circuits. However, the molecular mechanisms of the impact of early-life stress on PFC development and function are not well understood. In this study, we found that repeated stress exposure during the first postnatal week hampered dendritic development in layers II/III and V pyramidal neurons in the dorsal agranular cingulate cortex (ACd) and prelimbic cortex (PL) of neonatal mice. The deleterious effects of early postnatal stress on structural plasticity persisted to adulthood only in ACd layer V pyramidal neurons. Most importantly, concurrent blockade of corticotropin-releasing factor receptor 1 (CRF1) by systemic antalarmin administration (20 mu g/g of body weight) during early-life stress exposure prevented stress-induced apical dendritic retraction and spine loss in ACd layer V neurons and impairments in PFC-dependent cognitive tasks. Moreover, the magnitude of dendritic regression, especially the shrinkage of apical branches, of ACd layer V neurons predicted the degree of cognitive deficits in stressed mice. Our data highlight the region-specific effects of early postnatal stress on the structural plasticity of prefrontal pyramidal neurons, and suggest a critical role of CRF1 in modulating early-life stress-induced prefrontal abnormalities.

语种英语
WOS记录号WOS:000351022900016
项目编号81171284 ; 81301152 ; 20120001110046 ; 7133259
资助机构National Natural Science Foundation of China ; International Brain Research Organization, the Research Fund for the Doctoral Program of Higher Education of China ; Beijing Natural Science Foundation
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54631
专题北京大学精神卫生研究所
北京大学口腔医学院_综合治疗科
北京大学精神卫生研究所_精神科
北京大学精神卫生研究所_药理室
作者单位1.Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China
2.Shanxi Med Univ, Dayi Hosp, Dept Mental Hlth, Taiyuan, Peoples R China
3.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100191, Peoples R China
4.Max Planck Inst Psychiat, Dept Stress Neurobiol & Neurogenet, D-80804 Munich, Germany
5.Zhejiang Univ, Zhejiang Prov Key Lab Neurobiol, Key Lab Med Neurobiol, Dept Neurobiol,Minist Hlth China,Sch Med, Hangzhou 310058, Zhejiang, Peoples R China
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Yang, Xiao-Dun,Liao, Xue-Mei,Uribe-Marino, Andres,et al. Stress during a Critical Postnatal Period Induces Region-Specific Structural Abnormalities and Dysfunction of the Prefrontal Cortex via CRF1[J]. NEUROPSYCHOPHARMACOLOGY,2015,40(5):1203-1215.
APA Yang, Xiao-Dun.,Liao, Xue-Mei.,Uribe-Marino, Andres.,Liu, Rui.,Xie, Xiao-Meng.,...&Si, Tian-Mei.(2015).Stress during a Critical Postnatal Period Induces Region-Specific Structural Abnormalities and Dysfunction of the Prefrontal Cortex via CRF1.NEUROPSYCHOPHARMACOLOGY,40(5),1203-1215.
MLA Yang, Xiao-Dun,et al."Stress during a Critical Postnatal Period Induces Region-Specific Structural Abnormalities and Dysfunction of the Prefrontal Cortex via CRF1".NEUROPSYCHOPHARMACOLOGY 40.5(2015):1203-1215.
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