|Endoscopic resection therapies for rectal neuroendocrine tumors: A systematic review and meta-analysis|
|Zhou, Xin1; Xie, Haiting1; Xie, Lingduo1; Li, Jing2; Cao, Weihua2; Fu, Wei1|
|关键词||Endoscopic Mucosal Resection Endoscopic Submucosal Dissection Gastrointestinal Endoscopy Rectal Neuroendocrine Tumor|
|刊名||JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY|
|WOS标题词||Science & Technology|
|类目[WOS]||Gastroenterology & Hepatology|
|研究领域[WOS]||Gastroenterology & Hepatology|
|关键词[WOS]||CARCINOID-TUMORS ; MUCOSAL-RESECTION ; SUBMUCOSAL-DISSECTION ; LIGATION DEVICE ; CONSENSUS GUIDELINES ; METASTASIS ; MANAGEMENT ; PROGNOSIS ; FEATURES ; TRENDS|
Background and Aim: Among various endoscopic resection therapies, including conventional endoscopic mucosal resection (EMR) only with a snare after submucosal injection, modified EMR (m-EMR) with other assistant devices such as a ligation band or a suction cap, and endoscopic submucosal dissection (ESD), we aimed to study which is the best choice for rectal neuroendocrine tumors.
Methods: A broad literature research was performed, and a systematic review and meta-analysis were conducted.
Results: Ten retrospective studies with 650 patients were included. Complete resection rates were significantly higher in the ESD group compared with the EMR group (relative risk [RR] 0.89, 95% confidence interval [CI] [0.79, 0.99]), in the m-EMR group compared with the conventional EMR group (RR 0.72, 95% CI [0.60, 0.86]), and was comparable between the ESD group and the m-EMR group (RR 1.03, 95% CI [0.95, 1.11]). Procedure time was significantly longer in the ESD group than in the EMR group (standard mean differences -1.37, 95% CI [-1.99, -0.75]), but there was no significant difference between that of the m-EMR group and ESD group (standard mean differences -1.50, 95% CI [-3.14, 0.14]). Local recurrence occurred in five cases in the EMR group (5/328) and did not occur in the ESD group (0/209).
Conclusions: ESD or m-EMR techniques could be applied to rectal neuroendocrine tumors with indications for endoscopic treatment. m-EMR procedures appear to be comparable with ESD in the treatment of rectal neuroendocrine tumors. However, the findings have to be carefully interpreted due to the lower level of evidence.
|作者单位||1.Peking Univ Hlth Sci Ctr, Sch Publ Hlth, Dept Gen Surg, Beijing, Peoples R China|
2.Peking Univ Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing, Peoples R China
|Zhou, Xin,Xie, Haiting,Xie, Lingduo,et al. Endoscopic resection therapies for rectal neuroendocrine tumors: A systematic review and meta-analysis[J]. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY,2014,29(2):259-268.|
|APA||Zhou, Xin,Xie, Haiting,Xie, Lingduo,Li, Jing,Cao, Weihua,&Fu, Wei.(2014).Endoscopic resection therapies for rectal neuroendocrine tumors: A systematic review and meta-analysis.JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY,29(2),259-268.|
|MLA||Zhou, Xin,et al."Endoscopic resection therapies for rectal neuroendocrine tumors: A systematic review and meta-analysis".JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 29.2(2014):259-268.|