北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学公共卫生学院  > 期刊论文
学科主题: 公共卫生
题名:
Promoting effects of milk on the development of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumors in rats
作者: Ma, De-Fu; Katoh, Ryohei; Zhou, Hong; Wang, Pei-Yu
关键词: mammary tumor ; milk ; smooth muscle actin ; proliferating cell nuclear antigen ; estrogen receptor
刊名: ACTA HISTOCHEMICA ET CYTOCHEMICA
发表日期: 2007
DOI: 10.1267/ahc.07008
卷: 40, 期:2, 页:61-67
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology
研究领域[WOS]: Cell Biology
关键词[WOS]: BREAST-CANCER ; DAIRY-PRODUCTS ; RISK ; CARCINOMA ; ESTROGEN ; COWS ; FAT ; PROGESTERONE ; NUTRIENTS ; HORMONES
英文摘要:

To assess the effect of milk on the development of 7,12-dimethylbenz(a) anthracene (DMBA)-induced mammary tumors, 48 female Sprague-Dawley rats treated with DMBA were divided into 3 groups and given 1 of 3 test solutions for 20 weeks as their drinking liquid: milk, estrone sulfate solution or tap water. The milk group showed a significantly great incidence (75%) in tumor development compared with the water group (38%) and was comparable to the estrone sulfate group (69%). Mean tumor number per rat in the milk group was significantly higher than that in the water group (p=0.009). We classified the mammary tumors into three histological types: intraductal papilloma, fibroadenoma, and adenocarcinoma. Although the percent of intraductal papilloma and fibroadenoma was almost same among the three groups, malignant tumor was found only in the milk and estrone sulfate groups. In conclusion, our results indicate that milk as well as estrone sulfate promotes the development of DMBA-induced mammary tumors in rat and could be associated with the occurrence of adenocarcinoma.

语种: 英语
WOS记录号: WOS:000247727500004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54640
Appears in Collections:北京大学公共卫生学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Univ Yamanashi, Interdisciplinary Grad Sch Med & Engn, Dept Human Pathol, Yamanashi 4093898, Japan
2.Peking Univ, Sch Publ Hlth, Dept Social Med & Hlth Educ, Beijing 100083, Peoples R China

Recommended Citation:
Ma, De-Fu,Katoh, Ryohei,Zhou, Hong,et al. Promoting effects of milk on the development of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumors in rats[J]. ACTA HISTOCHEMICA ET CYTOCHEMICA,2007,40(2):61-67.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Ma, De-Fu]'s Articles
[Katoh, Ryohei]'s Articles
[Zhou, Hong]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Ma, De-Fu]‘s Articles
[Katoh, Ryohei]‘s Articles
[Zhou, Hong]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2018  北京大学医学部 - Feedback
Powered by CSpace