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Promoting effects of milk on the development of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumors in rats
Ma, De-Fu; Katoh, Ryohei; Zhou, Hong; Wang, Pei-Yu
关键词Mammary Tumor Milk Smooth Muscle Actin Proliferating Cell Nuclear Antigen Estrogen Receptor
刊名ACTA HISTOCHEMICA ET CYTOCHEMICA
2007
DOI10.1267/ahc.07008
40期:2页:61-67
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology
研究领域[WOS]Cell Biology
关键词[WOS]BREAST-CANCER ; DAIRY-PRODUCTS ; RISK ; CARCINOMA ; ESTROGEN ; COWS ; FAT ; PROGESTERONE ; NUTRIENTS ; HORMONES
英文摘要

To assess the effect of milk on the development of 7,12-dimethylbenz(a) anthracene (DMBA)-induced mammary tumors, 48 female Sprague-Dawley rats treated with DMBA were divided into 3 groups and given 1 of 3 test solutions for 20 weeks as their drinking liquid: milk, estrone sulfate solution or tap water. The milk group showed a significantly great incidence (75%) in tumor development compared with the water group (38%) and was comparable to the estrone sulfate group (69%). Mean tumor number per rat in the milk group was significantly higher than that in the water group (p=0.009). We classified the mammary tumors into three histological types: intraductal papilloma, fibroadenoma, and adenocarcinoma. Although the percent of intraductal papilloma and fibroadenoma was almost same among the three groups, malignant tumor was found only in the milk and estrone sulfate groups. In conclusion, our results indicate that milk as well as estrone sulfate promotes the development of DMBA-induced mammary tumors in rat and could be associated with the occurrence of adenocarcinoma.

语种英语
WOS记录号WOS:000247727500004
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54640
专题北京大学公共卫生学院
作者单位1.Univ Yamanashi, Interdisciplinary Grad Sch Med & Engn, Dept Human Pathol, Yamanashi 4093898, Japan
2.Peking Univ, Sch Publ Hlth, Dept Social Med & Hlth Educ, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Ma, De-Fu,Katoh, Ryohei,Zhou, Hong,et al. Promoting effects of milk on the development of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumors in rats[J]. ACTA HISTOCHEMICA ET CYTOCHEMICA,2007,40(2):61-67.
APA Ma, De-Fu,Katoh, Ryohei,Zhou, Hong,&Wang, Pei-Yu.(2007).Promoting effects of milk on the development of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumors in rats.ACTA HISTOCHEMICA ET CYTOCHEMICA,40(2),61-67.
MLA Ma, De-Fu,et al."Promoting effects of milk on the development of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumors in rats".ACTA HISTOCHEMICA ET CYTOCHEMICA 40.2(2007):61-67.
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