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学科主题: 基础医学
题名:
Mesoaccumbens dopamine signaling alteration underlies behavioral transition from tolerance to sensitization to morphine rewarding properties during morphine withdrawal
作者: Sun, Linlin1,2,3,4; Hu, Ling1,2,3,4; Li, Yijing1,2,3,4; Cui, Cailian1,2,3,4
关键词: Dopamine (DA) neuronal firing ; Mesoaccumbens DA signaling ; Morphine withdrawal ; Nucleus accumbens (NAc) ; Ventral tegmental area (VTA)
刊名: BRAIN STRUCTURE & FUNCTION
发表日期: 2014-09-01
DOI: 10.1007/s00429-013-0599-2
卷: 219, 期:5, 页:1755-1771
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Anatomy & Morphology ; Neurosciences
研究领域[WOS]: Anatomy & Morphology ; Neurosciences & Neurology
关键词[WOS]: VENTRAL TEGMENTAL AREA ; NUCLEUS-ACCUMBENS ; DRUG-ADDICTION ; IMPULSE FLOW ; ELECTROACUPUNCTURE TREATMENT ; NONLINEAR RELATIONSHIP ; NEURONAL-ACTIVITY ; INDUCED CPP ; IN-VIVO ; RATS
英文摘要:

Although the firing activity of dopamine (DA) neurons in the ventral tegmental area (VTA) and the behavioral response to morphine rewarding properties alter as opiate withdrawal, little is known about the dynamic changes in DA signal pathway from the VTA to the nucleus accumbens (NAc) during prolonged withdrawal, and whether the changes are indicative of vulnerability to relapse of drug abuse. Here we report that morphine spontaneously withdrawn (SW) rats are incapable of responding to small dose of morphine-induced conditioned place preference (CPP) from 24h-SW to 30d-SW, but recover response at 45d-SW. Interestingly, mesoaccumbens DA signaling, including the firing of DA neurons in the VTA, contents of DA and its metabolic ratio, and the membrane level of dopamine D-1 receptor in the NAc elicited by morphine challenge, display a similar pattern of time-dependent changes during morphine withdrawal. Moreover, blockade of D-1 receptor abolishes this behavioral transition. In addition, a strong correlation was found between % change in CPP score and membrane D-1 receptor level induced by morphine challenge. These results indicate a time-dependent behavioral switch from tolerance to sensitization during the prolonged withdrawal, which could offer a window for therapeutic intervention via manipulations of D-1 receptors.

语种: 英语
所属项目编号: 2009CB522003 ; 31271163
项目资助者: National Basic Research Program ; National Natural Science Foundation of China
WOS记录号: WOS:000341375500018
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54646
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China
2.Minist Educ, Key Lab Neurosci, Beijing 100191, Peoples R China
3.Minist Publ Hlth, Beijing 100191, Peoples R China
4.Peking Univ, Sch Basic Med Sci, Dept Neurobiol, Beijing 100191, Peoples R China

Recommended Citation:
Sun, Linlin,Hu, Ling,Li, Yijing,et al. Mesoaccumbens dopamine signaling alteration underlies behavioral transition from tolerance to sensitization to morphine rewarding properties during morphine withdrawal[J]. BRAIN STRUCTURE & FUNCTION,2014,219(5):1755-1771.
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