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学科主题基础医学
Mesoaccumbens dopamine signaling alteration underlies behavioral transition from tolerance to sensitization to morphine rewarding properties during morphine withdrawal
Sun, Linlin1,2,3,4; Hu, Ling1,2,3,4; Li, Yijing1,2,3,4; Cui, Cailian1,2,3,4
关键词Dopamine (DA) neuronal firing Mesoaccumbens DA signaling Morphine withdrawal Nucleus accumbens (NAc) Ventral tegmental area (VTA)
刊名BRAIN STRUCTURE & FUNCTION
2014-09-01
DOI10.1007/s00429-013-0599-2
219期:5页:1755-1771
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Anatomy & Morphology ; Neurosciences
研究领域[WOS]Anatomy & Morphology ; Neurosciences & Neurology
关键词[WOS]VENTRAL TEGMENTAL AREA ; NUCLEUS-ACCUMBENS ; DRUG-ADDICTION ; IMPULSE FLOW ; ELECTROACUPUNCTURE TREATMENT ; NONLINEAR RELATIONSHIP ; NEURONAL-ACTIVITY ; INDUCED CPP ; IN-VIVO ; RATS
英文摘要

Although the firing activity of dopamine (DA) neurons in the ventral tegmental area (VTA) and the behavioral response to morphine rewarding properties alter as opiate withdrawal, little is known about the dynamic changes in DA signal pathway from the VTA to the nucleus accumbens (NAc) during prolonged withdrawal, and whether the changes are indicative of vulnerability to relapse of drug abuse. Here we report that morphine spontaneously withdrawn (SW) rats are incapable of responding to small dose of morphine-induced conditioned place preference (CPP) from 24h-SW to 30d-SW, but recover response at 45d-SW. Interestingly, mesoaccumbens DA signaling, including the firing of DA neurons in the VTA, contents of DA and its metabolic ratio, and the membrane level of dopamine D-1 receptor in the NAc elicited by morphine challenge, display a similar pattern of time-dependent changes during morphine withdrawal. Moreover, blockade of D-1 receptor abolishes this behavioral transition. In addition, a strong correlation was found between % change in CPP score and membrane D-1 receptor level induced by morphine challenge. These results indicate a time-dependent behavioral switch from tolerance to sensitization during the prolonged withdrawal, which could offer a window for therapeutic intervention via manipulations of D-1 receptors.

语种英语
WOS记录号WOS:000341375500018
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54646
Collection北京大学基础医学院_神经生物学系
北京大学基础医学院
作者单位1.Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China
2.Minist Educ, Key Lab Neurosci, Beijing 100191, Peoples R China
3.Minist Publ Hlth, Beijing 100191, Peoples R China
4.Peking Univ, Sch Basic Med Sci, Dept Neurobiol, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Sun, Linlin,Hu, Ling,Li, Yijing,et al. Mesoaccumbens dopamine signaling alteration underlies behavioral transition from tolerance to sensitization to morphine rewarding properties during morphine withdrawal[J]. BRAIN STRUCTURE & FUNCTION,2014,219(5):1755-1771.
APA Sun, Linlin,Hu, Ling,Li, Yijing,&Cui, Cailian.(2014).Mesoaccumbens dopamine signaling alteration underlies behavioral transition from tolerance to sensitization to morphine rewarding properties during morphine withdrawal.BRAIN STRUCTURE & FUNCTION,219(5),1755-1771.
MLA Sun, Linlin,et al."Mesoaccumbens dopamine signaling alteration underlies behavioral transition from tolerance to sensitization to morphine rewarding properties during morphine withdrawal".BRAIN STRUCTURE & FUNCTION 219.5(2014):1755-1771.
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