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学科主题: 公共卫生
题名:
Multigenerations Assessment of Dietary Nucleotides Consumption in Weaned Rats
作者: Xu, Meihong1,2; Ma, Yi1,2; Xu, Linlin1,2; Xu, Yajun1,2; Li, Yong1,2
关键词: dietary nucleotides ; development ; after weaning ; safety ; Sprague-Dawley rat
刊名: BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY
发表日期: 2012-12-01
DOI: 10.1002/bdrb.21033
卷: 95, 期:6, 页:460-466
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Genetics & Heredity ; Toxicology
研究领域[WOS]: Oncology ; Genetics & Heredity ; Toxicology
关键词[WOS]: SERUM URIC-ACID ; INFANT NUTRITION ; NUCLEOSIDES ; FORMULA ; RIBONUCLEOTIDES ; REDUCTION ; THERAPY ; WOMEN ; LIVER ; MICE
英文摘要:

With the multifaceted activities of nucleotides, there is a history of safe consumption of dietary nucleotides (NTs) in the human diet. This study investigated the multigenerations cumulative toxicity on rats development after weaning. Weaning rats (F0) were fed with NTs at the dosage of 0.01, 0.04, 0.16, 0.64, and 1.28% (wt/wt) for 90 days and then mated for 1:1 pattern. The offspring was F1. F1 rats were fed with NTs for 90 days after weaning. Afterwards, F1 go on to the second reproductive part. We repeated the above process, until F3 rats were born. We observed the weight, food consumption in the whole experiment, and detected the blood indicators and organ pathology at the terminal. No abnormal reaction, behavior disorder, and organ pathology related to toxic symptom were observed in NTs-treated groups. Weight gain and diet utilization ratio of males in each NTs group had significant increase after weaning (p < 0.05). With the exception of decrease in uric acid (p < 0.05) of NTs male, there were no differences between the control and NTs groups in blood indicators. NTs could promote early growth and development of rats after weaning, especially in males.

语种: 英语
所属项目编号: 2006BAD27B08
项目资助者: Ministry of Science and Technology of the People&prime ; s Republic of China
WOS记录号: WOS:000312153800008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54651
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100191, Peoples R China
2.Peking Univ, Beijing Key Lab Toxicol Res & Risk Assessment Foo, Beijing 100191, Peoples R China

Recommended Citation:
Xu, Meihong,Ma, Yi,Xu, Linlin,et al. Multigenerations Assessment of Dietary Nucleotides Consumption in Weaned Rats[J]. BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY,2012,95(6):460-466.
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