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Multigenerations Assessment of Dietary Nucleotides Consumption in Weaned Rats
Xu, Meihong1,2; Ma, Yi1,2; Xu, Linlin1,2; Xu, Yajun1,2; Li, Yong1,2
关键词Dietary Nucleotides Development After Weaning Safety Sprague-dawley Rat
刊名BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY
2012-12-01
DOI10.1002/bdrb.21033
95期:6页:460-466
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Genetics & Heredity ; Toxicology
研究领域[WOS]Oncology ; Genetics & Heredity ; Toxicology
关键词[WOS]SERUM URIC-ACID ; INFANT NUTRITION ; NUCLEOSIDES ; FORMULA ; RIBONUCLEOTIDES ; REDUCTION ; THERAPY ; WOMEN ; LIVER ; MICE
英文摘要

With the multifaceted activities of nucleotides, there is a history of safe consumption of dietary nucleotides (NTs) in the human diet. This study investigated the multigenerations cumulative toxicity on rats development after weaning. Weaning rats (F0) were fed with NTs at the dosage of 0.01, 0.04, 0.16, 0.64, and 1.28% (wt/wt) for 90 days and then mated for 1:1 pattern. The offspring was F1. F1 rats were fed with NTs for 90 days after weaning. Afterwards, F1 go on to the second reproductive part. We repeated the above process, until F3 rats were born. We observed the weight, food consumption in the whole experiment, and detected the blood indicators and organ pathology at the terminal. No abnormal reaction, behavior disorder, and organ pathology related to toxic symptom were observed in NTs-treated groups. Weight gain and diet utilization ratio of males in each NTs group had significant increase after weaning (p < 0.05). With the exception of decrease in uric acid (p < 0.05) of NTs male, there were no differences between the control and NTs groups in blood indicators. NTs could promote early growth and development of rats after weaning, especially in males.

语种英语
WOS记录号WOS:000312153800008
项目编号2006BAD27B08
资助机构Ministry of Science and Technology of the People&prime ; s Republic of China
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54651
专题北京大学公共卫生学院
北京大学公共卫生学院_营养与食品卫生学系
北京大学公共卫生学院_公共卫生学院
作者单位1.Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100191, Peoples R China
2.Peking Univ, Beijing Key Lab Toxicol Res & Risk Assessment Foo, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Xu, Meihong,Ma, Yi,Xu, Linlin,et al. Multigenerations Assessment of Dietary Nucleotides Consumption in Weaned Rats[J]. BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY,2012,95(6):460-466.
APA Xu, Meihong,Ma, Yi,Xu, Linlin,Xu, Yajun,&Li, Yong.(2012).Multigenerations Assessment of Dietary Nucleotides Consumption in Weaned Rats.BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY,95(6),460-466.
MLA Xu, Meihong,et al."Multigenerations Assessment of Dietary Nucleotides Consumption in Weaned Rats".BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY 95.6(2012):460-466.
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