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学科主题: 临床医学
题名:
Characterization of CD3+CD4-CD8-(double negative) T cells reconstitution in patients following hematopoietic stem-cell transplantation
作者: Ye, Haige; Chang, Yingjun; Zhao, Xiangyu; Huang, Xiaojun
关键词: CD3+CD4-CD8-double negative T cells ; Reconstitution ; HSCT ; aGVHD
刊名: TRANSPLANT IMMUNOLOGY
发表日期: 2011-12-01
DOI: 10.1016/j.trim.2011.08.004
卷: 25, 期:4, 页:180-186
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology ; Transplantation
研究领域[WOS]: Immunology ; Transplantation
关键词[WOS]: UNMANIPULATED HAPLOIDENTICAL BLOOD ; MARROW TRANSPLANTATION ; REGULATORY CELLS ; IN-VIVO ; PLATELET ENGRAFTMENT ; TOLERANCE ; DIFFERENTIATION ; AUTOIMMUNITY ; MALIGNANCIES ; DISEASE
英文摘要:

Background: CD3+CD4-CD8- double negative (DN) T cells, as a distinct subset of regulatory T cells (Tregs), played a pivotal role in patients following hematopoietic stem-cell transplantation.

Methods: This study examines the behavior of CD3+CD4-CD8- double negative (DN) T cells in 73 patients at days 30, 60, 90 and 180 after allo-HSCT.

Results: There was no significant difference in neutrophil and platelet engraftment between the higher and lower absolute counts of 30 days DN Tregs (p=0.674, 0.863, respectively). The reconstitution of DN Tregs was significantly slower than that of CD8+, CD4+, and CD3+CD8+CD28- T cells (p<0.001), but significantly faster than that of CD19+ and CD4+CD25+ T cells (p<0.001, p=0.032, respectively). Importantly, in the HLA mismatched group, DN Tregs reconstitution had significant effect on aGVHD (p=0.027) and there was significant correlation between aGVHD and DN Tregs reconstitution (p=0.035). DN Tregs reconstitution was significantly faster in the patients who were devoid of aGVHD than that of patients who developed aGVHD. Furthermore, we compared the absolute value of DN Tregs at 30 days, 60 days, 90 days and 180 days after allo-HSCT with grade aGVHD and found an inverse linear relationship in the HLA mismatched group (n=37, P<0.001, r=0.573).

Conclusions: The successful expansion of DN Tregs at 60 days after allo-HCST may help avoid severe manifestations of aGVHD in the HLA mismatched group, suggesting that DN Tregs have potential protection effect against aGVHD. (C) 2011 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 30725038 ; IRT0702 ; 30971292
项目资助者: China National Funds for Distinguished Young Scientist&prime ; s ; Funds for Creative Research Groups of China ; National Natural Science Fund
WOS记录号: WOS:000298908900002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54653
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Inst Hematol, Beijing 100044, Peoples R China

Recommended Citation:
Ye, Haige,Chang, Yingjun,Zhao, Xiangyu,et al. Characterization of CD3+CD4-CD8-(double negative) T cells reconstitution in patients following hematopoietic stem-cell transplantation[J]. TRANSPLANT IMMUNOLOGY,2011,25(4):180-186.
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