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学科主题临床医学
Characterization of CD3+CD4-CD8-(double negative) T cells reconstitution in patients following hematopoietic stem-cell transplantation
Ye, Haige; Chang, Yingjun; Zhao, Xiangyu; Huang, Xiaojun
关键词cd3+cd4-cd8-double Negative t Cells Reconstitution Hsct Agvhd
刊名TRANSPLANT IMMUNOLOGY
2011-12-01
DOI10.1016/j.trim.2011.08.004
25期:4页:180-186
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology ; Transplantation
研究领域[WOS]Immunology ; Transplantation
关键词[WOS]UNMANIPULATED HAPLOIDENTICAL BLOOD ; MARROW TRANSPLANTATION ; REGULATORY CELLS ; IN-VIVO ; PLATELET ENGRAFTMENT ; TOLERANCE ; DIFFERENTIATION ; AUTOIMMUNITY ; MALIGNANCIES ; DISEASE
英文摘要

Background: CD3+CD4-CD8- double negative (DN) T cells, as a distinct subset of regulatory T cells (Tregs), played a pivotal role in patients following hematopoietic stem-cell transplantation.

Methods: This study examines the behavior of CD3+CD4-CD8- double negative (DN) T cells in 73 patients at days 30, 60, 90 and 180 after allo-HSCT.

Results: There was no significant difference in neutrophil and platelet engraftment between the higher and lower absolute counts of 30 days DN Tregs (p=0.674, 0.863, respectively). The reconstitution of DN Tregs was significantly slower than that of CD8+, CD4+, and CD3+CD8+CD28- T cells (p<0.001), but significantly faster than that of CD19+ and CD4+CD25+ T cells (p<0.001, p=0.032, respectively). Importantly, in the HLA mismatched group, DN Tregs reconstitution had significant effect on aGVHD (p=0.027) and there was significant correlation between aGVHD and DN Tregs reconstitution (p=0.035). DN Tregs reconstitution was significantly faster in the patients who were devoid of aGVHD than that of patients who developed aGVHD. Furthermore, we compared the absolute value of DN Tregs at 30 days, 60 days, 90 days and 180 days after allo-HSCT with grade aGVHD and found an inverse linear relationship in the HLA mismatched group (n=37, P<0.001, r=0.573).

Conclusions: The successful expansion of DN Tregs at 60 days after allo-HCST may help avoid severe manifestations of aGVHD in the HLA mismatched group, suggesting that DN Tregs have potential protection effect against aGVHD. (C) 2011 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000298908900002
项目编号30725038 ; IRT0702 ; 30971292
资助机构China National Funds for Distinguished Young Scientist&prime ; s ; Funds for Creative Research Groups of China ; National Natural Science Fund
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54653
专题北京大学第二临床医学院_血液科
作者单位Peking Univ, Peoples Hosp, Inst Hematol, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Ye, Haige,Chang, Yingjun,Zhao, Xiangyu,et al. Characterization of CD3+CD4-CD8-(double negative) T cells reconstitution in patients following hematopoietic stem-cell transplantation[J]. TRANSPLANT IMMUNOLOGY,2011,25(4):180-186.
APA Ye, Haige,Chang, Yingjun,Zhao, Xiangyu,&Huang, Xiaojun.(2011).Characterization of CD3+CD4-CD8-(double negative) T cells reconstitution in patients following hematopoietic stem-cell transplantation.TRANSPLANT IMMUNOLOGY,25(4),180-186.
MLA Ye, Haige,et al."Characterization of CD3+CD4-CD8-(double negative) T cells reconstitution in patients following hematopoietic stem-cell transplantation".TRANSPLANT IMMUNOLOGY 25.4(2011):180-186.
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