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学科主题: 药学
题名:
Development of the fingerprints for the quality of the roots of Salvia miltiorrhiza and its related preparations by HPLC-DAD and LC-MSn
作者: Liu, Ai-Hua; Lin, Yan-Hua; Yang, Min; Guo, Hui; Guan, Shu-Hong; Sun, Jiang-Hao; Guo, De-An
关键词: Salvia miltiorrhiza ; salvianolic acids ; tanshinones ; fingerprint ; HPLC-DAD ; LC-MSn
刊名: JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
发表日期: 2007-02-01
DOI: 10.1016/j.jchromb.2006.08.002
卷: 846, 期:1-2, 页:32-41
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]: RATS ; EXTRACTS ; DANSHEN ; CELLS
英文摘要:

High-performance liquid chromatographic (HPLC) fingerprints were developed for identification of both lipophilic and hydrophilic components of the roots of Salvia miltiorrhiza and four related preparations. These samples were separated with an Agilent Zorbax Extend C-18 reserved-phase column (5 gym, 250 mm x 4.6 mm) by linear gradient elution using water-phosphoric acid (100:0.026, v/v) and acetonitrile as mobile phase. The flow rate was 0.8 ml/min and the detector wavelength was set at 280 nm. Mean chromatograms and correlation coefficients of samples were calculated by the software "Similarity Evaluation System for Chromatographic Fingerprint of TCM". The correlation coefficients of Danshen and Fufang Danshen tablets (FDT) samples were in the range of 0.352-0.993 and 0.768-0.987, respectively. The correlation coefficients of Compound Danshen dripping pills (CDDP), Danshen injection (DSI) and Xiangdan injection (XDI) samples were higher than 0.928, 0.850 and 0.960, respectively. It was the first time to identify 34 peaks by comparing with standard compounds and using liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS") technique. All results indicated that the developed fingerprint assay could be readily utilized as a quality control method for S. miltiorrhiza and its related preparations. (c) 2006 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000244281100006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54666
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Chinese Acad Sci, Shanghai Res Ctr TCM Modernizat, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimt Drugs, Beijing 100083, Peoples R China

Recommended Citation:
Liu, Ai-Hua,Lin, Yan-Hua,Yang, Min,et al. Development of the fingerprints for the quality of the roots of Salvia miltiorrhiza and its related preparations by HPLC-DAD and LC-MSn[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2007,846(1-2):32-41.
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