|Effect of Neoadjuvant Chemotherapy on the Serum Levels of Bone Turnover Markers in Women with Early-Stage Breast Cancer|
|Chen, YangYang1; Xu, GuoBin1; Yang, Feng2|
|WOS标题词||Science & Technology|
|研究领域[WOS]||Science & Technology - Other Topics|
|关键词[WOS]||VITAMIN-D ; ADJUVANT CHEMOTHERAPY ; POSTMENOPAUSAL WOMEN ; MINERAL DENSITY ; OSTEOPOROSIS ; METASTASIS ; MANAGEMENT ; DISEASE ; MECHANISMS|
To evaluate effects of neoadjuvant chemotherapy on the bone turnover markers of preoperational breast cancer patients.
Forty-one breast cancer patients (29 premenopausal and 12 postmenopausal) and 60 healthy women (30 premenopausal and 30 postmenopausal) aged 30-64 years, were evaluated for their bone status. Serum levels of the bone formation markers PINP and BAP, as well as the resorption markers ICTP and beta-Crosslaps in addition to E2, FSH, 25(OH)D and PTH were measured at the initial diagnosis and at 24 hours after each four chemotherapy cycles. BMD T-scores were determined in 12 patients 6 months after the neoadjuvant chemotherapies.
The baseline levels of both bone formation and resorption markers in premenopausal patients were higher than in premenopausal healthy women (p<0.05), while no statistic difference was observed between postmenopausal patients and postmenopausal healthy women. Regardless of the menopausal status, chemotherapy increased the ICTP and beta-Crosslaps levels (p<0.05), but decreased the BAP and PINP levels (p<0.05), the later one significantly more with Taxane medication (p<0.01, p<0.05). Chemotherapy caused significant decreases of 25(OH) D levels in premenopausal (p<0.01) and postmenopausal (p<0.05) patients, however, did not affect the PTH concentrations. In premenopausal patients the E2 level decreased, while the FSH level increased after chemotherapy (p<0.05). Patients with pronounced ICTP and beta-Crosslaps combined with reduced BAP and PINP serum concentrations after neoadjuvant chemotherapies were prone to develop osteoporosis 6 month later.
Neoadjuvant chemotherapy appeared to promote bone resorption and inhibit bone formation in both postmenopausal and premenopausal early-stage breast patients.
|作者单位||1.Peking Univ, Canc Hosp & Inst, Dept Clin Lab, Beijing 100871, Peoples R China|
2.Peking Univ, Canc Hosp & Inst, Dept Breast Surg, Beijing 100871, Peoples R China
|Chen, YangYang,Xu, GuoBin,Yang, Feng. Effect of Neoadjuvant Chemotherapy on the Serum Levels of Bone Turnover Markers in Women with Early-Stage Breast Cancer[J]. PLOS ONE,2015,10(4).|
|APA||Chen, YangYang,Xu, GuoBin,&Yang, Feng.(2015).Effect of Neoadjuvant Chemotherapy on the Serum Levels of Bone Turnover Markers in Women with Early-Stage Breast Cancer.PLOS ONE,10(4).|
|MLA||Chen, YangYang,et al."Effect of Neoadjuvant Chemotherapy on the Serum Levels of Bone Turnover Markers in Women with Early-Stage Breast Cancer".PLOS ONE 10.4(2015).|