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学科主题临床医学
Effect of Neoadjuvant Chemotherapy on the Serum Levels of Bone Turnover Markers in Women with Early-Stage Breast Cancer
Chen, YangYang1; Xu, GuoBin1; Yang, Feng2
刊名PLOS ONE
2015-04-29
DOI10.1371/journal.pone.0126053
10期:4
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]VITAMIN-D ; ADJUVANT CHEMOTHERAPY ; POSTMENOPAUSAL WOMEN ; MINERAL DENSITY ; OSTEOPOROSIS ; METASTASIS ; MANAGEMENT ; DISEASE ; MECHANISMS
英文摘要

Background

To evaluate effects of neoadjuvant chemotherapy on the bone turnover markers of preoperational breast cancer patients.

Methods

Forty-one breast cancer patients (29 premenopausal and 12 postmenopausal) and 60 healthy women (30 premenopausal and 30 postmenopausal) aged 30-64 years, were evaluated for their bone status. Serum levels of the bone formation markers PINP and BAP, as well as the resorption markers ICTP and beta-Crosslaps in addition to E2, FSH, 25(OH)D and PTH were measured at the initial diagnosis and at 24 hours after each four chemotherapy cycles. BMD T-scores were determined in 12 patients 6 months after the neoadjuvant chemotherapies.

Results

The baseline levels of both bone formation and resorption markers in premenopausal patients were higher than in premenopausal healthy women (p<0.05), while no statistic difference was observed between postmenopausal patients and postmenopausal healthy women. Regardless of the menopausal status, chemotherapy increased the ICTP and beta-Crosslaps levels (p<0.05), but decreased the BAP and PINP levels (p<0.05), the later one significantly more with Taxane medication (p<0.01, p<0.05). Chemotherapy caused significant decreases of 25(OH) D levels in premenopausal (p<0.01) and postmenopausal (p<0.05) patients, however, did not affect the PTH concentrations. In premenopausal patients the E2 level decreased, while the FSH level increased after chemotherapy (p<0.05). Patients with pronounced ICTP and beta-Crosslaps combined with reduced BAP and PINP serum concentrations after neoadjuvant chemotherapies were prone to develop osteoporosis 6 month later.

Conclusions

Neoadjuvant chemotherapy appeared to promote bone resorption and inhibit bone formation in both postmenopausal and premenopausal early-stage breast patients.

语种英语
WOS记录号WOS:000353711600169
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54667
专题北京大学临床肿瘤学院_临床实验室
作者单位1.Peking Univ, Canc Hosp & Inst, Dept Clin Lab, Beijing 100871, Peoples R China
2.Peking Univ, Canc Hosp & Inst, Dept Breast Surg, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Chen, YangYang,Xu, GuoBin,Yang, Feng. Effect of Neoadjuvant Chemotherapy on the Serum Levels of Bone Turnover Markers in Women with Early-Stage Breast Cancer[J]. PLOS ONE,2015,10(4).
APA Chen, YangYang,Xu, GuoBin,&Yang, Feng.(2015).Effect of Neoadjuvant Chemotherapy on the Serum Levels of Bone Turnover Markers in Women with Early-Stage Breast Cancer.PLOS ONE,10(4).
MLA Chen, YangYang,et al."Effect of Neoadjuvant Chemotherapy on the Serum Levels of Bone Turnover Markers in Women with Early-Stage Breast Cancer".PLOS ONE 10.4(2015).
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