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学科主题: 口腔医学
题名:
A green fabrication approach of gelatin/CM-chitosan hybrid hydrogel for wound healing
作者: Yang, Chao1,3,5; Xu, Ling1,2,3; Zhou, Ying1,3; Zhang, Xiangmei3; Huang, Xin1,3; Wang, Min2; Han, Ye3; Zhai, Maolin2; Wei, Shicheng3,4; Li, Jiuqiang2
关键词: Gelatin ; Carboxymethyl chitosan ; Hydrogel ; Radiation crosslinking ; Wound healing
刊名: CARBOHYDRATE POLYMERS
发表日期: 2010-11-11
DOI: 10.1016/j.carbpol.2010.07.013
卷: 82, 期:4, 页:1297-1305
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Applied ; Chemistry, Organic ; Polymer Science
研究领域[WOS]: Chemistry ; Polymer Science
关键词[WOS]: ELECTRON-BEAM IRRADIATION ; HUMAN-SKIN COLLAGENASE ; CROSS-LINKING ; CHITIN ; DEGRADATION ; CHITOSAN/ALGINATE ; BIOMATERIALS ; DERIVATIVES ; FIBROBLAST ; PRECURSOR
英文摘要:

A series of hydrogels were fabricated from an aqueous solution of gelatin and carboxymethyl chitosan (CM-chitosan) by radiation-induced-crosslinking at ambient temperature. Several physicochemical and biological properties of the hydrogels were investigated to evaluate their potential as wound healing materials. By increasing the CM-chitosan content in the hybrid hydrogels, their swelling ability increased significantly, while the compressive modulus decreased. The miscibility between gelatin and CM-chitosan molecules led to a semi-interpenetrate network after crosslinking. Observed by SEM, scaffolds with a homogeneous interconnected pore structure were obtained after lyophilizing the hydrogels. The enzyme degradation rate of the hydrogels was controlled by adjusting the procedure, which could be matched to the healing rate of the wound. Furthermore, the gelatin/CM-chitosan hydrogels promoted cell attachment and rapid growth of fibroblasts on the material. Due to the high water absorption capacity, a similar compressive modulus with soft tissue, controllable biodegradation, and excellent biocompatibility, the gelatin/CM-chitosan hybrid hydrogels have potential as skin scaffolds and wound healing materials. (C) 2010 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 2007CB936103 ; PKUJC2009001
项目资助者: State Key Development Program for Basic Research of China ; Peking University Interdisciplinary and Emerging Disciplines Research Foundation ; Peking University ; Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry
WOS记录号: WOS:000283042100038
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54668
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: 1.Peking Univ, Sch Stomatol, Beijing 100044, Peoples R China
2.Peking Univ, Dept Energy & Resources Engn, Coll Engn, Beijing 100871, Peoples R China
3.Peking Univ, Beijing Natl Lab Mol Sci, Dept Appl Chem, Coll Chem & Mol Engn, Beijing 100871, Peoples R China
4.Peking Univ, Ctr Biomed Mat & Tissue Engn, Acad Adv Interdisciplinary Studies, Beijing 100871, Peoples R China
5.Peking Univ, Dept Appl Linguist, Hlth Sci Ctr, Beijing 100191, Peoples R China

Recommended Citation:
Yang, Chao,Xu, Ling,Zhou, Ying,et al. A green fabrication approach of gelatin/CM-chitosan hybrid hydrogel for wound healing[J]. CARBOHYDRATE POLYMERS,2010,82(4):1297-1305.
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