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The MELD scoring system for predicting prognosis in patients with severe hepatitis after plasma exchange treatment
Yu, Jian-Wu1; Wang, Gui-Qiang2; Zhao, Yong-Hua1; Sun, Li-Jie1; Wang, Shu-Qin1; Li, Shu-Chen1
关键词Severe Hepatitis Model For End-stage Liver Disease Plasma Exchange Mortality
刊名HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL
2007-10-01
6期:5页:492-496
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]ARTIFICIAL LIVER SUPPORT ; CYTOKINE CONCENTRATIONS ; FAILURE ; DISEASE ; MODEL ; CHILD
英文摘要

BACKGROUND: Hepatic failure caused by severe hepatitis is a clinical syndrome where the major liver functions, particularly detoxification, synthetic functions, and metabolic regulation are impaired to different degrees, and may result in major life-threatening complications such as hepatic encephalopathy, ascites, jaundice, cholestasis, bleeding and hepatorenal syndrome. Plasma exchange (PE) has been found useful in treating patients with fulminant hepatic failure by removing hepatic toxins and replacement of clotting factors, so PE treatment has temporary supportive effects on liver failure caused by severe viral hepatitis. in this study, our aim was to predict the prognosis of patients with severe hepatitis after PE treatment using the end-stage liver disease (MELD) scoring system.

METHODS: Two hundred and twenty patients were randomly divided into PE and control groups, and the MELD score was calculated for each patient according to the original formula. The efficacy of PE was assessed by mortality or improvement in biochemical parameters and MELD score.

RESULTS: The levels of total bilirubin and international normalised ratio (INR) in patients whose MELD scores were between 30 and 39 were lower than those before PE treatment, as those in patients whose MELD scores were 40 or higher. The mortality of patients in the PE group with MELD scores from 30 to 39 was 50.0%, while it was 83.3% in the control group (P<0.01). The mortality of patients with MELD scores higher than 40 was 90.0% in the PE group and 98.0% in the control group (P>0.05).

CONCLUSIONS: PE treatment can decrease the serum total bilirubin level and INR and MELD score of patients with severe hepatitis and improve liver function. Compared with the control group, PE can significantly decrease the mortality of patients with MELD scores from 30 to 39, but has no effect in patients with MELD scores of 40 or higher.

语种英语
WOS记录号WOS:000254390100009
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54672
专题北京大学第一临床医学院_感染疾病科
作者单位1.Harbin Med Coll, Dept Infect Dis, Affiliated Hosp 2, Harbin 150086, Peoples R China
2.Peking Univ, First Hosp, Dept Infect Dis, Beijing 100034, Peoples R China
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GB/T 7714
Yu, Jian-Wu,Wang, Gui-Qiang,Zhao, Yong-Hua,et al. The MELD scoring system for predicting prognosis in patients with severe hepatitis after plasma exchange treatment[J]. HEPATOBILIARY &amp; PANCREATIC DISEASES INTERNATIONAL,2007,6(5):492-496.
APA Yu, Jian-Wu,Wang, Gui-Qiang,Zhao, Yong-Hua,Sun, Li-Jie,Wang, Shu-Qin,&Li, Shu-Chen.(2007).The MELD scoring system for predicting prognosis in patients with severe hepatitis after plasma exchange treatment.HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL,6(5),492-496.
MLA Yu, Jian-Wu,et al."The MELD scoring system for predicting prognosis in patients with severe hepatitis after plasma exchange treatment".HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL 6.5(2007):492-496.
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