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学科主题: 临床医学
题名:
Flow patterns and wall shear stress distribution in human internal carotid arteries: The geometric effect on the risk for stenoses
作者: Zhang, Chi1; Xie, Sheng2; Li, Shuyu1; Pu, Fang1; Deng, Xiaoyan1; Fan, Yubo1; Li, Deyu1
关键词: Internal carotid artery ; Carotid siphon ; Atherosclerotic stenosis ; Geometry ; Sinusoidal blood flow
刊名: JOURNAL OF BIOMECHANICS
发表日期: 2012-01-03
DOI: 10.1016/j.jbiomech.2011.10.001
卷: 45, 期:1, 页:83-89
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biophysics ; Engineering, Biomedical
研究领域[WOS]: Biophysics ; Engineering
关键词[WOS]: BLOOD-FLOW ; ATHEROSCLEROTIC LESIONS ; NUMERICAL-SIMULATION ; PULSATILE FLOW ; AORTIC-ARCH ; BIFURCATION ; HEMODYNAMICS ; LOCALIZATION ; ANEURYSMS
英文摘要:

It has been widely observed that atherosclerotic stenosis occurs at sites with complex hemodynamics, such as arteries with high curvature or bifurcations. These regions usually have very low or highly oscillatory wall shear stress (WSS). In the present study, 3D sinusoidally pulsatile blood flow through the models of internal carotid artery (ICA) with different geometries was investigated with computational simulation. Three preferred sites of stenoses were found along the carotid siphon with low and highly oscillatory WSS. The risk for stenoses at these sites was scaled with the values of time-averaged WSS and oscillating shear index (OSI). The local risk for stenoses at every preferred site of stenoses was found different between 3 types of ICA, indicating that the geometry of the blood vessel plays significant roles in the atherogenesis. Specifically, the large curvature and planarity of the vessel were found to increase the risk for stenoses, because they tend to lower WSS and elevate OSI. Therefore, the geometric study makes it possible to estimate the stenosis location in the ICA siphon as long as the shape of ICA was measured. (C) 2011 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 10925208 ; 11072022 ; 10772019
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000299448500011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54678
Appears in Collections:北京大学第一临床医学院_放射治疗科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Radiol, Beijing, Peoples R China
2.Beihang Univ, Key Lab Biomech & Mechanobiol, Minist Educ, Sch Biol Sci & Med Engn, Beijing 100191, Peoples R China

Recommended Citation:
Zhang, Chi,Xie, Sheng,Li, Shuyu,et al. Flow patterns and wall shear stress distribution in human internal carotid arteries: The geometric effect on the risk for stenoses[J]. JOURNAL OF BIOMECHANICS,2012,45(1):83-89.
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