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学科主题临床医学
Flow patterns and wall shear stress distribution in human internal carotid arteries: The geometric effect on the risk for stenoses
Zhang, Chi1; Xie, Sheng2; Li, Shuyu1; Pu, Fang1; Deng, Xiaoyan1; Fan, Yubo1; Li, Deyu1
关键词Internal Carotid Artery Carotid Siphon Atherosclerotic Stenosis Geometry Sinusoidal Blood Flow
刊名JOURNAL OF BIOMECHANICS
2012-01-03
DOI10.1016/j.jbiomech.2011.10.001
45期:1页:83-89
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biophysics ; Engineering, Biomedical
研究领域[WOS]Biophysics ; Engineering
关键词[WOS]BLOOD-FLOW ; ATHEROSCLEROTIC LESIONS ; NUMERICAL-SIMULATION ; PULSATILE FLOW ; AORTIC-ARCH ; BIFURCATION ; HEMODYNAMICS ; LOCALIZATION ; ANEURYSMS
英文摘要

It has been widely observed that atherosclerotic stenosis occurs at sites with complex hemodynamics, such as arteries with high curvature or bifurcations. These regions usually have very low or highly oscillatory wall shear stress (WSS). In the present study, 3D sinusoidally pulsatile blood flow through the models of internal carotid artery (ICA) with different geometries was investigated with computational simulation. Three preferred sites of stenoses were found along the carotid siphon with low and highly oscillatory WSS. The risk for stenoses at these sites was scaled with the values of time-averaged WSS and oscillating shear index (OSI). The local risk for stenoses at every preferred site of stenoses was found different between 3 types of ICA, indicating that the geometry of the blood vessel plays significant roles in the atherogenesis. Specifically, the large curvature and planarity of the vessel were found to increase the risk for stenoses, because they tend to lower WSS and elevate OSI. Therefore, the geometric study makes it possible to estimate the stenosis location in the ICA siphon as long as the shape of ICA was measured. (C) 2011 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000299448500011
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被引频次:30[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54678
专题北京大学第一临床医学院_放射治疗科
北京大学第三临床医学院_信息中心
作者单位1.Peking Univ, Hosp 1, Dept Radiol, Beijing, Peoples R China
2.Beihang Univ, Key Lab Biomech & Mechanobiol, Minist Educ, Sch Biol Sci & Med Engn, Beijing 100191, Peoples R China
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Zhang, Chi,Xie, Sheng,Li, Shuyu,et al. Flow patterns and wall shear stress distribution in human internal carotid arteries: The geometric effect on the risk for stenoses[J]. JOURNAL OF BIOMECHANICS,2012,45(1):83-89.
APA Zhang, Chi.,Xie, Sheng.,Li, Shuyu.,Pu, Fang.,Deng, Xiaoyan.,...&Li, Deyu.(2012).Flow patterns and wall shear stress distribution in human internal carotid arteries: The geometric effect on the risk for stenoses.JOURNAL OF BIOMECHANICS,45(1),83-89.
MLA Zhang, Chi,et al."Flow patterns and wall shear stress distribution in human internal carotid arteries: The geometric effect on the risk for stenoses".JOURNAL OF BIOMECHANICS 45.1(2012):83-89.
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