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PDGF-C controls proliferation and is down-regulated by retinoic acid in mouse embryonic palatal mesenchymal cells
Han, Jing; Xiao, Ying; Lin, Jiuxiang; Li, Yong
关键词Pdgf-c All-trans Retinoic Acid Cleft Palate Proliferation Mouse Embryonic Palatal Mesenchymal Cells
刊名BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY
2006-10-01
77期:5页:438-444
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Genetics & Heredity ; Toxicology
研究领域[WOS]Oncology ; Genetics & Heredity ; Toxicology
关键词[WOS]GROWTH-FACTOR-C ; CLEFT-PALATE ; ALPHA-RECEPTOR ; BETA-RECEPTOR ; BINDING-SITE ; CYCLIN-E ; EXPRESSION ; FAMILY ; ACTIVATION ; INDUCTION
英文摘要

BACKGROUND: Platelet-derived growth factor C (PDGF-C) was recently identified as a member of the PDGF ligand family. Some observation suggests that PDGF-C could play an important role in palatogenesis highlighted by the Pdgfc(-/-) mouse with cleft palate, which led us to examine the mechanism of PDGF-C signaling in palatogenesis. It is well known that retinoic acid (RA) is a teratogen that can effectively induce cleft palate in the mouse. Due to the critical roles of PDGF-C and RA in cleft palate, the link between cleft palate induced by RA and loss of PDGF-C was investigated. METHODS: Retarded mesenchymal proliferation is an important cause for cleft palate. To clarify the mechanism of PDGF-C in palatogenesis, we evaluated the effects of PDGF-C and anti-PDGF-C neutralizing antibody on proliferation activity in mouse embryonic palatal mesenchymal (MEPM) cells. RESULTS: Briefly, our results show PDGF-C promotes proliferation, anti-PDGF-C antibody inhibits it in MEPM cells, and RA downregulates the PDGF-C expression both at the mRNA and protein levels. CONCLUSIONS: These demonstrate that PDGF-C is a potent mitogen for MEPM cells, implying that inactivated PDGF-C by gene-targeting or reduced PDGF-C by RA may both cause inhibition of proliferation in palatal shelves, which might account for the pathogenesis of cleft palate in Pdgfc(-/-) mouse or RA-treated mouse. In conclusion, our results suggest that PDGF-C signaling is a new mechanism of cleft palate induced by RA.

语种英语
WOS记录号WOS:000241548800005
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54679
专题北京大学公共卫生学院
作者单位1.Peking Univ, Sch Stomatol, Beijing 100083, Peoples R China
2.Peking Univ, Sch Publ Hlth, Dept Food Sci & Nutr, Beijing 100083, Peoples R China
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Han, Jing,Xiao, Ying,Lin, Jiuxiang,et al. PDGF-C controls proliferation and is down-regulated by retinoic acid in mouse embryonic palatal mesenchymal cells[J]. BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY,2006,77(5):438-444.
APA Han, Jing,Xiao, Ying,Lin, Jiuxiang,&Li, Yong.(2006).PDGF-C controls proliferation and is down-regulated by retinoic acid in mouse embryonic palatal mesenchymal cells.BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY,77(5),438-444.
MLA Han, Jing,et al."PDGF-C controls proliferation and is down-regulated by retinoic acid in mouse embryonic palatal mesenchymal cells".BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY 77.5(2006):438-444.
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