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学科主题: 临床医学
题名:
Dynamic changes of heme oxygenase-1 and carbon monoxide production in acute liver injury induced by carbon tetrachloride in rats
作者: Wen, Tao; Guan, Li; Zhang, Yan-Lin; Zhao, Jin-Yuan
关键词: heme oxygenase-1 ; carbon monoxide ; carbon tetrachloride ; liver injury ; oxidative stress
刊名: TOXICOLOGY
发表日期: 2006-11-10
DOI: 10.1016/j.tox.2006.08.014
卷: 228, 期:1, 页:51-57
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy ; Toxicology
研究领域[WOS]: Pharmacology & Pharmacy ; Toxicology
关键词[WOS]: INDUCED HEPATOTOXICITY ; LIPID-PEROXIDATION ; ISCHEMIA/REPERFUSION INJURY ; PROTECTIVE ROLE ; KINASE PATHWAY ; EXPRESSION ; MICE ; ANTIOXIDANT ; INDUCTION ; APOPTOSIS
英文摘要:

Heme oxygenase-1, a stress-responsive enzyme that catabolizes hemes into carbon monoxide, biliverdin, and iron, has been shown to play a pivotal role in many physiological and pathological situations. Here we investigated changes in HO-I enzyme activity and protein expression, and its end product carbon monoxide concentrations in the liver of rats after CCl4 treatment. We found that CCl4 administration not only induced severe liver damage in rats, as demonstrated by dramatic elevation of ALT, AST levels and severe histopathological changes, but also resulted in a prominent up-regulation of HO-I enzyme activity. Western blot and immunohistochemical analysis confirmed that expression of HO-I protein was also increased significantly in a time-dependent manner following CCl4 treatment, and localized mainly in liver cells around the central vein. In addition, CO concentrations in the liver Of CCl4-treated rats were elevated remarkably in the same time-dependent way as HO-1 induction in contrast to the control rats. These data indicated that HO-1/CO pathway was greatly up regulated in the liver of rats after CCl4 treatment, which might play an important protective role in the pathophysiological mechanism underlying CCl4-induced hepatotoxicity. It therefore suggested that more relevant studies should be carried out in the future to clarify the detailed mechanisms. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000242135900006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54680
Appears in Collections:北京大学第三临床医学院_职业病科_期刊论文

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作者单位: Peking Univ, Res Ctr Occupat Med, Hosp 3, Beijing 100083, Peoples R China

Recommended Citation:
Wen, Tao,Guan, Li,Zhang, Yan-Lin,et al. Dynamic changes of heme oxygenase-1 and carbon monoxide production in acute liver injury induced by carbon tetrachloride in rats[J]. TOXICOLOGY,2006,228(1):51-57.
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