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学科主题: 临床医学
题名:
Reduced IL-35 levels are associated with increased platelet aggregation and activation in patients with acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation
作者: Zhang, Xiaohui1; Zhou, Yi1; Xu, Lanping1; Han, Wei1; Chen, Huan1; Chen, Yuhong1; Fu, Haixia1; Zhou, Shiyuan1; Zhao, Jingzhong2; Wang, Qianming1; Feng, Feier1; Zhu, Xiaolu1; Liu, Kaiyan1; Huang, Xiaojun1
关键词: Allogeneic hematopoietic stem cell transplantation ; Acute graft-versus-host disease ; IL-35 ; Platelet aggregation
刊名: ANNALS OF HEMATOLOGY
发表日期: 2015-05-01
DOI: 10.1007/s00277-014-2278-7
卷: 94, 期:5, 页:837-845
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology
研究领域[WOS]: Hematology
关键词[WOS]: REGULATORY T-CELLS ; VASCULAR ENDOTHELIUM ; RISK-FACTORS ; ACUTE GVHD ; MICE ; CYTOKINE ; ENCEPHALOMYELITIS ; ATHEROTHROMBOSIS ; COMPLICATIONS ; SUPPRESSION
英文摘要:

Acute graft-versus-host disease (aGVHD) is a major complication associated with allogeneic hematopoietic stem cell transplantation (allo-HSCT). Interleukin (IL)-35 is a novel anti-inflammatory cytokine that suppresses the immune response. This prospective study explored IL-35 plasma levels in 65 patients after HSCT. The results revealed that the peripheral blood of patients with grades III-IV aGVHD (23.46 ng/ml) had reduced IL-35 compared to transplanted patients with grades I-II aGVHD (40.26 ng/ml, p < 0.01) or patients without aGVHD (41.40 ng/ml, p < 0.05). Allografts, including granulocyte colony-stimulating factor (G-CSF)-mobilized peripheral blood progenitor cell (PBPC) and G-CSF-primed bone marrow (GBM), from 38 patients were analyzed for IL-35 levels with respect to aGVHD. The patients who received lower levels of IL-35 cells in the GBM (28.0 ng/ml, p = 0.551) or lower levels of IL-35 in PBPC (53.46 ng/ml, p = 0.03) exhibited a higher incidence of aGVHD. Patients with aGVHD have increased platelet aggregation. IL-35 was added to patient blood in vitro, and platelet aggregation was inhibited by IL-35 in a dose-dependent manner. The markers of platelet activation (CD62P/PAC-1) can also be inhibited by IL-35. The results indicate that IL-35 may affect the development of aGVHD by inhibiting platelet activation and aggregation. Our data suggests that IL-35 represents a potentially effective therapeutic agent against aGVHD after allo-HSCT.

语种: 英语
所属项目编号: 81070449 ; 81270643 ; 7132194 ; 7112139
项目资助者: National Science Foundation of China ; Beijing Natural Science Foundation
WOS记录号: WOS:000351836900014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54683
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Inst Hematol, Beijing 100044, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Lab Med, Beijing 100044, Peoples R China

Recommended Citation:
Zhang, Xiaohui,Zhou, Yi,Xu, Lanping,et al. Reduced IL-35 levels are associated with increased platelet aggregation and activation in patients with acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation[J]. ANNALS OF HEMATOLOGY,2015,94(5):837-845.
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