IR@PKUHSC  > 北京大学第二临床医学院  > 血液科
学科主题临床医学
Reduced IL-35 levels are associated with increased platelet aggregation and activation in patients with acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation
Zhang, Xiaohui1; Zhou, Yi1; Xu, Lanping1; Han, Wei1; Chen, Huan1; Chen, Yuhong1; Fu, Haixia1; Zhou, Shiyuan1; Zhao, Jingzhong2; Wang, Qianming1; Feng, Feier1; Zhu, Xiaolu1; Liu, Kaiyan1; Huang, Xiaojun1
关键词Allogeneic Hematopoietic Stem Cell Transplantation Acute Graft-versus-host Disease Il-35 Platelet Aggregation
刊名ANNALS OF HEMATOLOGY
2015-05-01
DOI10.1007/s00277-014-2278-7
94期:5页:837-845
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology
资助者National Science Foundation of China ; Beijing Natural Science Foundation ; National Science Foundation of China ; Beijing Natural Science Foundation
研究领域[WOS]Hematology
关键词[WOS]REGULATORY T-CELLS ; VASCULAR ENDOTHELIUM ; RISK-FACTORS ; ACUTE GVHD ; MICE ; CYTOKINE ; ENCEPHALOMYELITIS ; ATHEROTHROMBOSIS ; COMPLICATIONS ; SUPPRESSION
英文摘要

Acute graft-versus-host disease (aGVHD) is a major complication associated with allogeneic hematopoietic stem cell transplantation (allo-HSCT). Interleukin (IL)-35 is a novel anti-inflammatory cytokine that suppresses the immune response. This prospective study explored IL-35 plasma levels in 65 patients after HSCT. The results revealed that the peripheral blood of patients with grades III-IV aGVHD (23.46 ng/ml) had reduced IL-35 compared to transplanted patients with grades I-II aGVHD (40.26 ng/ml, p < 0.01) or patients without aGVHD (41.40 ng/ml, p < 0.05). Allografts, including granulocyte colony-stimulating factor (G-CSF)-mobilized peripheral blood progenitor cell (PBPC) and G-CSF-primed bone marrow (GBM), from 38 patients were analyzed for IL-35 levels with respect to aGVHD. The patients who received lower levels of IL-35 cells in the GBM (28.0 ng/ml, p = 0.551) or lower levels of IL-35 in PBPC (53.46 ng/ml, p = 0.03) exhibited a higher incidence of aGVHD. Patients with aGVHD have increased platelet aggregation. IL-35 was added to patient blood in vitro, and platelet aggregation was inhibited by IL-35 in a dose-dependent manner. The markers of platelet activation (CD62P/PAC-1) can also be inhibited by IL-35. The results indicate that IL-35 may affect the development of aGVHD by inhibiting platelet activation and aggregation. Our data suggests that IL-35 represents a potentially effective therapeutic agent against aGVHD after allo-HSCT.

语种英语
所属项目编号81070449 ; 81270643 ; 7132194 ; 7112139
资助者National Science Foundation of China ; Beijing Natural Science Foundation ; National Science Foundation of China ; Beijing Natural Science Foundation
WOS记录号WOS:000351836900014
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54683
专题北京大学第二临床医学院_血液科
作者单位1.Peking Univ, Peoples Hosp, Inst Hematol, Beijing 100044, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Lab Med, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Xiaohui,Zhou, Yi,Xu, Lanping,et al. Reduced IL-35 levels are associated with increased platelet aggregation and activation in patients with acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation[J]. ANNALS OF HEMATOLOGY,2015,94(5):837-845.
APA Zhang, Xiaohui.,Zhou, Yi.,Xu, Lanping.,Han, Wei.,Chen, Huan.,...&Huang, Xiaojun.(2015).Reduced IL-35 levels are associated with increased platelet aggregation and activation in patients with acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.ANNALS OF HEMATOLOGY,94(5),837-845.
MLA Zhang, Xiaohui,et al."Reduced IL-35 levels are associated with increased platelet aggregation and activation in patients with acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation".ANNALS OF HEMATOLOGY 94.5(2015):837-845.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhang, Xiaohui]的文章
[Zhou, Yi]的文章
[Xu, Lanping]的文章
百度学术
百度学术中相似的文章
[Zhang, Xiaohui]的文章
[Zhou, Yi]的文章
[Xu, Lanping]的文章
必应学术
必应学术中相似的文章
[Zhang, Xiaohui]的文章
[Zhou, Yi]的文章
[Xu, Lanping]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。