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学科主题: 临床医学
题名:
Improved Retinal Ganglion Cell Survival through Retinal Microglia Suppression by a Chinese Herb Extract, Triptolide, in the DBA/2J Mouse Model of Glaucoma
作者: Yang, Fan; Wu, Lingling; Guo, Xiujuan; Wang, Dongmei; Li, Ying
关键词: DBA/2J mouse ; glaucoma ; microglia ; neuroprotection ; triptolide
刊名: OCULAR IMMUNOLOGY AND INFLAMMATION
发表日期: 2013-10-01
DOI: 10.3109/09273948.2013.806989
卷: 21, 期:5, 页:378-389
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Ophthalmology
研究领域[WOS]: Ophthalmology
关键词[WOS]: PROTECTS DOPAMINERGIC-NEURONS ; INFLAMMATION-MEDIATED DAMAGE ; NECROSIS-FACTOR-ALPHA ; TNF-ALPHA ; INTRAOCULAR-PRESSURE ; ACTIVATED MICROGLIA ; RESPONSES ; MICE ; NEURODEGENERATION ; NEUROPROTECTION
英文摘要:

To investigate the changes in retinal microglia and retinal ganglion cell (RGC) survival after long-term administration of a Chinese herb extract, triptolide, in a DBA/2J mice. DBA/2J mice (n = 96) were administered triptolide (n = 48) 25 mg/kg or vehicle (n = 48) and were judged at 7, 9, 11 months of age. Long-term triptolide treatment tended to attenuate the anterior segment pathology in experimental group, though intraocular pressure was not significantly different between the two groups. In the experimental group, RGC survival was improved (7, 9, 11 months: p = 0.035, 0.004, 0.014), and microglia activation was suppressed based on a more ramified appearance (9, 11 months: p = 0.024, 0.013) and a lower total microglial cell count (7, 9, 11 months: p = 0.028, 0.025, 0.014). Double-immunofluorescence staining revealed TNF? localized to microglia, TNFR1 localized to the RGCs and nerve fiber layer. These findings indicate that long-term triptolide administration suppressed microglia activation and improved RGC survival in DBA/2J mice.

语种: 英语
所属项目编号: 30571986
项目资助者: National Natural Science Funds of China
WOS记录号: WOS:000324403300006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54685
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: Peking Univ, Hosp 3, Beijing 100871, Peoples R China

Recommended Citation:
Yang, Fan,Wu, Lingling,Guo, Xiujuan,et al. Improved Retinal Ganglion Cell Survival through Retinal Microglia Suppression by a Chinese Herb Extract, Triptolide, in the DBA/2J Mouse Model of Glaucoma[J]. OCULAR IMMUNOLOGY AND INFLAMMATION,2013,21(5):378-389.
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