IR@PKUHSC  > 北京大学第三临床医学院
学科主题临床医学
Improved Retinal Ganglion Cell Survival through Retinal Microglia Suppression by a Chinese Herb Extract, Triptolide, in the DBA/2J Mouse Model of Glaucoma
Yang, Fan; Wu, Lingling; Guo, Xiujuan; Wang, Dongmei; Li, Ying
关键词Dba/2j Mouse Glaucoma Microglia Neuroprotection Triptolide
刊名OCULAR IMMUNOLOGY AND INFLAMMATION
2013-10-01
DOI10.3109/09273948.2013.806989
21期:5页:378-389
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Ophthalmology
研究领域[WOS]Ophthalmology
关键词[WOS]PROTECTS DOPAMINERGIC-NEURONS ; INFLAMMATION-MEDIATED DAMAGE ; NECROSIS-FACTOR-ALPHA ; TNF-ALPHA ; INTRAOCULAR-PRESSURE ; ACTIVATED MICROGLIA ; RESPONSES ; MICE ; NEURODEGENERATION ; NEUROPROTECTION
英文摘要

To investigate the changes in retinal microglia and retinal ganglion cell (RGC) survival after long-term administration of a Chinese herb extract, triptolide, in a DBA/2J mice. DBA/2J mice (n = 96) were administered triptolide (n = 48) 25 mg/kg or vehicle (n = 48) and were judged at 7, 9, 11 months of age. Long-term triptolide treatment tended to attenuate the anterior segment pathology in experimental group, though intraocular pressure was not significantly different between the two groups. In the experimental group, RGC survival was improved (7, 9, 11 months: p = 0.035, 0.004, 0.014), and microglia activation was suppressed based on a more ramified appearance (9, 11 months: p = 0.024, 0.013) and a lower total microglial cell count (7, 9, 11 months: p = 0.028, 0.025, 0.014). Double-immunofluorescence staining revealed TNF? localized to microglia, TNFR1 localized to the RGCs and nerve fiber layer. These findings indicate that long-term triptolide administration suppressed microglia activation and improved RGC survival in DBA/2J mice.

语种英语
WOS记录号WOS:000324403300006
项目编号30571986
资助机构National Natural Science Funds of China
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54685
专题北京大学第三临床医学院
北京大学第三临床医学院_眼科
作者单位Peking Univ, Hosp 3, Beijing 100871, Peoples R China
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GB/T 7714
Yang, Fan,Wu, Lingling,Guo, Xiujuan,et al. Improved Retinal Ganglion Cell Survival through Retinal Microglia Suppression by a Chinese Herb Extract, Triptolide, in the DBA/2J Mouse Model of Glaucoma[J]. OCULAR IMMUNOLOGY AND INFLAMMATION,2013,21(5):378-389.
APA Yang, Fan,Wu, Lingling,Guo, Xiujuan,Wang, Dongmei,&Li, Ying.(2013).Improved Retinal Ganglion Cell Survival through Retinal Microglia Suppression by a Chinese Herb Extract, Triptolide, in the DBA/2J Mouse Model of Glaucoma.OCULAR IMMUNOLOGY AND INFLAMMATION,21(5),378-389.
MLA Yang, Fan,et al."Improved Retinal Ganglion Cell Survival through Retinal Microglia Suppression by a Chinese Herb Extract, Triptolide, in the DBA/2J Mouse Model of Glaucoma".OCULAR IMMUNOLOGY AND INFLAMMATION 21.5(2013):378-389.
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