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学科主题: 临床医学
题名:
Low testosterone levels in women with diminished ovarian reserve impair embryo implantation rate: a retrospective case-control study
作者: Lu, Qun1,2; Shen, Huan1,2; Li, Yang3; Zhang, Chunfang4; Wang, Cong1; Chen, Xi1; Liang, Rong1; Wei, Lihui1,5
关键词: Diminished ovarian reserve ; Basal testosterone ; Ovarian response ; Pregnancy ; Implantation rate
刊名: JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
发表日期: 2014-04-01
DOI: 10.1007/s10815-014-0186-3
卷: 31, 期:4, 页:485-491
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Genetics & Heredity ; Obstetrics & Gynecology ; Reproductive Biology
研究领域[WOS]: Genetics & Heredity ; Obstetrics & Gynecology ; Reproductive Biology
关键词[WOS]: ANDROGEN RECEPTOR ; EXPRESSION ; FOLLICULOGENESIS ; SUPPLEMENTATION ; STIMULATION ; ENDOMETRIUM ; CELLS ; BASAL
英文摘要:

To investigate the association of basal testosterone (T) levels with the outcome of in vitro fertilization (IVF) in women with diminished ovarian reserve (DOR).

Complete clinical data on the first 223 IVF cycles in women with DOR were retrospectively analyzed. The associations of basal follicle stimulating hormone, luteinizing hormone, estradiol, and T levels with ovarian response and IVF outcome were studied.

Basal T levels were significantly different between pregnant and non-pregnant women. However, basal T levels showed no correlation with controlled ovarian hyperstimulation parameters after adjusting for age. The association of basal T levels with pregnancy rate was significant after adjusting for other impact factors. Using receiver operating characteristic (ROC) analysis, the basal T level of 1.115 nmol/L for predicting pregnancy outcome had a sensitivity of 82.80 % and specificity of 58.09 %. The women were divided into two groups based on this value; although the clinical characteristics and ovarian stimulation parameters were similar, the clinical pregnancy (16.18 % (11/68) vs. 40.15 % (53/132), respectively, p = 0.000) and implantation rates (10.07 % (15/149) vs. 22.41 % (65/290), respectively, p = 0.002) were significantly different in the low and high T level groups.

In women with DOR, the basal T level presented a positive association with pregnancy outcome in IVF. The poor reproductive outcome observed in women with lower basal T levels may be due to the decreased implantation rate.

语种: 英语
WOS记录号: WOS:000333703100014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54687
Appears in Collections:北京大学第二临床医学院_计划生育与生殖医学科_期刊论文

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作者单位: 1.Minist Educ, Key Lab Assisted Reprod, Beijing 100191, Peoples R China
2.Peking Univ, Reprod Med Ctr, Peoples Hosp, Beijing 100044, Peoples R China
3.Shandong Univ, Shandong Prov Hosp, Ctr Reprod Med, Jinan 250021, Peoples R China
4.Peking Univ, Peoples Hosp, Dept Clin Epidemiol & Biostat, Beijing 100044, Peoples R China
5.Peking Univ, Peoples Hosp, Dept Obstet & Gynecol, Beijing 100044, Peoples R China

Recommended Citation:
Lu, Qun,Shen, Huan,Li, Yang,et al. Low testosterone levels in women with diminished ovarian reserve impair embryo implantation rate: a retrospective case-control study[J]. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS,2014,31(4):485-491.
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