|Low testosterone levels in women with diminished ovarian reserve impair embryo implantation rate: a retrospective case-control study|
|Lu, Qun1,2; Shen, Huan1,2; Li, Yang3; Zhang, Chunfang4; Wang, Cong1; Chen, Xi1; Liang, Rong1; Wei, Lihui1,5|
|关键词||Diminished Ovarian Reserve Basal Testosterone Ovarian Response Pregnancy Implantation Rate|
|刊名||JOURNAL OF ASSISTED REPRODUCTION AND GENETICS|
|WOS标题词||Science & Technology|
|类目[WOS]||Genetics & Heredity ; Obstetrics & Gynecology ; Reproductive Biology|
|研究领域[WOS]||Genetics & Heredity ; Obstetrics & Gynecology ; Reproductive Biology|
|关键词[WOS]||ANDROGEN RECEPTOR ; EXPRESSION ; FOLLICULOGENESIS ; SUPPLEMENTATION ; STIMULATION ; ENDOMETRIUM ; CELLS ; BASAL|
To investigate the association of basal testosterone (T) levels with the outcome of in vitro fertilization (IVF) in women with diminished ovarian reserve (DOR).
Complete clinical data on the first 223 IVF cycles in women with DOR were retrospectively analyzed. The associations of basal follicle stimulating hormone, luteinizing hormone, estradiol, and T levels with ovarian response and IVF outcome were studied.
Basal T levels were significantly different between pregnant and non-pregnant women. However, basal T levels showed no correlation with controlled ovarian hyperstimulation parameters after adjusting for age. The association of basal T levels with pregnancy rate was significant after adjusting for other impact factors. Using receiver operating characteristic (ROC) analysis, the basal T level of 1.115 nmol/L for predicting pregnancy outcome had a sensitivity of 82.80 % and specificity of 58.09 %. The women were divided into two groups based on this value; although the clinical characteristics and ovarian stimulation parameters were similar, the clinical pregnancy (16.18 % (11/68) vs. 40.15 % (53/132), respectively, p = 0.000) and implantation rates (10.07 % (15/149) vs. 22.41 % (65/290), respectively, p = 0.002) were significantly different in the low and high T level groups.
In women with DOR, the basal T level presented a positive association with pregnancy outcome in IVF. The poor reproductive outcome observed in women with lower basal T levels may be due to the decreased implantation rate.
|作者单位||1.Minist Educ, Key Lab Assisted Reprod, Beijing 100191, Peoples R China|
2.Peking Univ, Reprod Med Ctr, Peoples Hosp, Beijing 100044, Peoples R China
3.Shandong Univ, Shandong Prov Hosp, Ctr Reprod Med, Jinan 250021, Peoples R China
4.Peking Univ, Peoples Hosp, Dept Clin Epidemiol & Biostat, Beijing 100044, Peoples R China
5.Peking Univ, Peoples Hosp, Dept Obstet & Gynecol, Beijing 100044, Peoples R China
|Lu, Qun,Shen, Huan,Li, Yang,et al. Low testosterone levels in women with diminished ovarian reserve impair embryo implantation rate: a retrospective case-control study[J]. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS,2014,31(4):485-491.|
|APA||Lu, Qun.,Shen, Huan.,Li, Yang.,Zhang, Chunfang.,Wang, Cong.,...&Wei, Lihui.(2014).Low testosterone levels in women with diminished ovarian reserve impair embryo implantation rate: a retrospective case-control study.JOURNAL OF ASSISTED REPRODUCTION AND GENETICS,31(4),485-491.|
|MLA||Lu, Qun,et al."Low testosterone levels in women with diminished ovarian reserve impair embryo implantation rate: a retrospective case-control study".JOURNAL OF ASSISTED REPRODUCTION AND GENETICS 31.4(2014):485-491.|