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学科主题: 基础医学
题名:
Repeated peripheral electrical stimulations suppress both morphine-induced CPP and reinstatement of extinguished CPP in rats: accelerated expression of PPE and PPD mRNA in NAc implicated
作者: Shi, XD; Wang, GB; Ma, YY; Ren, W; Luo, F; Cui, CL; Han, JS
关键词: conditioned place preference (CPP) ; peripheral electric stimulation (PES) ; reinstatement ; preproenkephalin (PPE) ; preprodynorphin (PPD)
刊名: MOLECULAR BRAIN RESEARCH
发表日期: 2004-11-04
DOI: 10.1016/j.molbrainres.2004.07.016
卷: 130, 期:1-2, 页:124-133
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: CONDITIONED PLACE PREFERENCE ; ENDOGENOUS OPIOID SYSTEMS ; DIFFERENT FREQUENCIES ; INDUCED SENSITIZATION ; C-FOS ; DRUG ; COCAINE ; HEROIN ; ELECTROACUPUNCTURE ; ADDICTION
英文摘要:

Previous studies have shown that peripheral electrical stimulation (PES) can suppress morphine-induced conditioned place preference (CPP) and the reinstatement of extinguished CPP in the rat. The present study was performed to elucidate if preproenkephalin (PPE) and preprodynorphin (PPD) mRNAs in the nucleus accumbens (NAc) play a role in this event. Rats were trained with morphine for 4 days to establish CPP paradigm. They were then given 15-min test once a day for eight consecutive days for extinction trial. Twenty-four hours after the 8th session of extinction trials, rats were given peripheral electrical stimulation (PES) at 2 or 100 Hz once a day for 3 days, then a morphine-priming injection at a dose of 1, 2, or 4 mg/kg to reinstate the extinguished CPP. At the end of the experiment, PPE and PPD mRNA levels in the nucleus acccumbens (NAc) were determined by the semiquantitative RT-PCR technique. The results showed that PES at 2- and 100-Hz administered 30 min a day for 3 days suppressed both the expression of morphine-induced CPP and the reinstatement of extinguished CPP. PES at 2 Hz increased preproenkephalin (PPE) mRNA levels, whereas PES of 100 Hz that of preprodynorphin (PPD) mRNA levels in the NAc. These findings suggest that enkephalin and dynorphin in NAc may play important roles in the mechanisms underlying the inhibitory effect of PES on the expression and reinstatement of morphine-induced CPP in rats. (C) 2004 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000225167600014
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54689
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: Peking Univ, Minist Educ, Key Lab Neurosci, Neurosci Res Inst, Beijing 100083, Peoples R China

Recommended Citation:
Shi, XD,Wang, GB,Ma, YY,et al. Repeated peripheral electrical stimulations suppress both morphine-induced CPP and reinstatement of extinguished CPP in rats: accelerated expression of PPE and PPD mRNA in NAc implicated[J]. MOLECULAR BRAIN RESEARCH,2004,130(1-2):124-133.
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