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Repeated peripheral electrical stimulations suppress both morphine-induced CPP and reinstatement of extinguished CPP in rats: accelerated expression of PPE and PPD mRNA in NAc implicated
Shi, XD; Wang, GB; Ma, YY; Ren, W; Luo, F; Cui, CL; Han, JS
关键词conditioned place preference (CPP) peripheral electric stimulation (PES) reinstatement preproenkephalin (PPE) preprodynorphin (PPD)
刊名MOLECULAR BRAIN RESEARCH
2004-11-04
DOI10.1016/j.molbrainres.2004.07.016
130期:1-2页:124-133
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]CONDITIONED PLACE PREFERENCE ; ENDOGENOUS OPIOID SYSTEMS ; DIFFERENT FREQUENCIES ; INDUCED SENSITIZATION ; C-FOS ; DRUG ; COCAINE ; HEROIN ; ELECTROACUPUNCTURE ; ADDICTION
英文摘要

Previous studies have shown that peripheral electrical stimulation (PES) can suppress morphine-induced conditioned place preference (CPP) and the reinstatement of extinguished CPP in the rat. The present study was performed to elucidate if preproenkephalin (PPE) and preprodynorphin (PPD) mRNAs in the nucleus accumbens (NAc) play a role in this event. Rats were trained with morphine for 4 days to establish CPP paradigm. They were then given 15-min test once a day for eight consecutive days for extinction trial. Twenty-four hours after the 8th session of extinction trials, rats were given peripheral electrical stimulation (PES) at 2 or 100 Hz once a day for 3 days, then a morphine-priming injection at a dose of 1, 2, or 4 mg/kg to reinstate the extinguished CPP. At the end of the experiment, PPE and PPD mRNA levels in the nucleus acccumbens (NAc) were determined by the semiquantitative RT-PCR technique. The results showed that PES at 2- and 100-Hz administered 30 min a day for 3 days suppressed both the expression of morphine-induced CPP and the reinstatement of extinguished CPP. PES at 2 Hz increased preproenkephalin (PPE) mRNA levels, whereas PES of 100 Hz that of preprodynorphin (PPD) mRNA levels in the NAc. These findings suggest that enkephalin and dynorphin in NAc may play important roles in the mechanisms underlying the inhibitory effect of PES on the expression and reinstatement of morphine-induced CPP in rats. (C) 2004 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000225167600014
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被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54689
专题北京大学基础医学院_神经生物学系
作者单位Peking Univ, Minist Educ, Key Lab Neurosci, Neurosci Res Inst, Beijing 100083, Peoples R China
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Shi, XD,Wang, GB,Ma, YY,et al. Repeated peripheral electrical stimulations suppress both morphine-induced CPP and reinstatement of extinguished CPP in rats: accelerated expression of PPE and PPD mRNA in NAc implicated[J]. MOLECULAR BRAIN RESEARCH,2004,130(1-2):124-133.
APA Shi, XD.,Wang, GB.,Ma, YY.,Ren, W.,Luo, F.,...&Han, JS.(2004).Repeated peripheral electrical stimulations suppress both morphine-induced CPP and reinstatement of extinguished CPP in rats: accelerated expression of PPE and PPD mRNA in NAc implicated.MOLECULAR BRAIN RESEARCH,130(1-2),124-133.
MLA Shi, XD,et al."Repeated peripheral electrical stimulations suppress both morphine-induced CPP and reinstatement of extinguished CPP in rats: accelerated expression of PPE and PPD mRNA in NAc implicated".MOLECULAR BRAIN RESEARCH 130.1-2(2004):124-133.
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