IR@PKUHSC  > 北京大学临床肿瘤学院  > 肿瘤内科
学科主题临床医学
Deletion or Epigenetic Silencing of AJAP1 on 1p36 in Glioblastoma
Lin, Ningjing2; Di, Chunhui1,3; Bortoff, Kathy3; Fu, Jinrong3; Truszkowski, Peter3; Killela, Patrick3,4; Duncan, Chris3,4; McLendon, Roger3,4; Bigner, Darell3,4; Gregory, Simon6; Adamson, David Cory1,3,5,7
刊名MOLECULAR CANCER RESEARCH
2012-02-01
DOI10.1158/1541-7786.MCR-10-0109
10期:2页:208-217
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Cell Biology
研究领域[WOS]Oncology ; Cell Biology
关键词[WOS]PROTEIN SHREW-1 ; DOWN-REGULATION ; GENE ; HYPERMETHYLATION ; TEMOZOLOMIDE ; MULTIFORME ; MIGRATION ; METHYLATION ; JUNCTIONS ; PATHWAYS
英文摘要

Glioblastoma is universally fatal because of its propensity for rapid recurrence due to highly migratory tumor cells. Unraveling the genomic complexity that underlies this migratory characteristic could provide therapeutic targets that would greatly complement current surgical therapy. Using multiple high-resolution genomic screening methods, we identified a single locus, adherens junctional associated protein 1 (AJAP1) on chromosome 1p36 that is lost or epigenetically silenced in many glioblastomas. We found AJAP1 expression absent or reduced in 86% and 100% of primary glioblastoma tumors and cell lines, respectively, and the loss of expression correlates with AJAP1 methylation. Restoration of AJAP1 gene expression by transfection or demethylation agents results in decreased tumor cell migration in glioblastoma cell lines. This work shows the significant loss of expression of AJAP1 in glioblastoma and provides evidence of its role in the highly migratory characteristic of these tumors. Mol Cancer Res; 10(2); 208-17. (C)2012 AACR.

语种英语
WOS记录号WOS:000300613300003
项目编号K12 CA100639-02 ; 5P50 NS20023 ; R37 CA011898 ; 5PO CA108786 ; 1R21-NS-048549-01
资助机构NIH ; American Brain Tumor Association ; Neurosurgery Research Education Foundation ; National Cancer Center ; NINDS ; Merit Award ; SPORE
引用统计
被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54690
专题北京大学临床肿瘤学院_肿瘤内科
作者单位1.Durham VA Med Ctr, Durham, NC USA
2.Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA
3.Duke Univ, Med Ctr, Dept Pathol, Durham, NC 27710 USA
4.Duke Univ, Med Ctr, Dept Neurobiol, Durham, NC 27710 USA
5.Duke Univ, Med Ctr, Duke Ctr Human Genet, Durham, NC 27710 USA
6.Peking Univ, Dept Oncol, Sch Oncol, Beijing Canc Hosp & Inst, Beijing 100871, Peoples R China
7.Duke Univ, Med Ctr, Preston Robert Tisch Brain Tumor Ctr, Durham, NC 27710 USA
推荐引用方式
GB/T 7714
Lin, Ningjing,Di, Chunhui,Bortoff, Kathy,et al. Deletion or Epigenetic Silencing of AJAP1 on 1p36 in Glioblastoma[J]. MOLECULAR CANCER RESEARCH,2012,10(2):208-217.
APA Lin, Ningjing.,Di, Chunhui.,Bortoff, Kathy.,Fu, Jinrong.,Truszkowski, Peter.,...&Adamson, David Cory.(2012).Deletion or Epigenetic Silencing of AJAP1 on 1p36 in Glioblastoma.MOLECULAR CANCER RESEARCH,10(2),208-217.
MLA Lin, Ningjing,et al."Deletion or Epigenetic Silencing of AJAP1 on 1p36 in Glioblastoma".MOLECULAR CANCER RESEARCH 10.2(2012):208-217.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Lin, Ningjing]的文章
[Di, Chunhui]的文章
[Bortoff, Kathy]的文章
百度学术
百度学术中相似的文章
[Lin, Ningjing]的文章
[Di, Chunhui]的文章
[Bortoff, Kathy]的文章
必应学术
必应学术中相似的文章
[Lin, Ningjing]的文章
[Di, Chunhui]的文章
[Bortoff, Kathy]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。