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学科主题: 临床医学
题名:
Deletion or Epigenetic Silencing of AJAP1 on 1p36 in Glioblastoma
作者: Lin, Ningjing2; Di, Chunhui1,3; Bortoff, Kathy3; Fu, Jinrong3; Truszkowski, Peter3; Killela, Patrick3,4; Duncan, Chris3,4; McLendon, Roger3,4; Bigner, Darell3,4; Gregory, Simon6; Adamson, David Cory1,3,5,7
刊名: MOLECULAR CANCER RESEARCH
发表日期: 2012-02-01
DOI: 10.1158/1541-7786.MCR-10-0109
卷: 10, 期:2, 页:208-217
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Cell Biology
研究领域[WOS]: Oncology ; Cell Biology
关键词[WOS]: PROTEIN SHREW-1 ; DOWN-REGULATION ; GENE ; HYPERMETHYLATION ; TEMOZOLOMIDE ; MULTIFORME ; MIGRATION ; METHYLATION ; JUNCTIONS ; PATHWAYS
英文摘要:

Glioblastoma is universally fatal because of its propensity for rapid recurrence due to highly migratory tumor cells. Unraveling the genomic complexity that underlies this migratory characteristic could provide therapeutic targets that would greatly complement current surgical therapy. Using multiple high-resolution genomic screening methods, we identified a single locus, adherens junctional associated protein 1 (AJAP1) on chromosome 1p36 that is lost or epigenetically silenced in many glioblastomas. We found AJAP1 expression absent or reduced in 86% and 100% of primary glioblastoma tumors and cell lines, respectively, and the loss of expression correlates with AJAP1 methylation. Restoration of AJAP1 gene expression by transfection or demethylation agents results in decreased tumor cell migration in glioblastoma cell lines. This work shows the significant loss of expression of AJAP1 in glioblastoma and provides evidence of its role in the highly migratory characteristic of these tumors. Mol Cancer Res; 10(2); 208-17. (C)2012 AACR.

语种: 英语
所属项目编号: K12 CA100639-02 ; 5P50 NS20023 ; R37 CA011898 ; 5PO CA108786 ; 1R21-NS-048549-01
项目资助者: NIH ; American Brain Tumor Association ; Neurosurgery Research Education Foundation ; National Cancer Center ; NINDS ; Merit Award ; SPORE
WOS记录号: WOS:000300613300003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54690
Appears in Collections:北京大学临床肿瘤学院_肿瘤内科_期刊论文

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作者单位: 1.Durham VA Med Ctr, Durham, NC USA
2.Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA
3.Duke Univ, Med Ctr, Dept Pathol, Durham, NC 27710 USA
4.Duke Univ, Med Ctr, Dept Neurobiol, Durham, NC 27710 USA
5.Duke Univ, Med Ctr, Duke Ctr Human Genet, Durham, NC 27710 USA
6.Peking Univ, Dept Oncol, Sch Oncol, Beijing Canc Hosp & Inst, Beijing 100871, Peoples R China
7.Duke Univ, Med Ctr, Preston Robert Tisch Brain Tumor Ctr, Durham, NC 27710 USA

Recommended Citation:
Lin, Ningjing,Di, Chunhui,Bortoff, Kathy,et al. Deletion or Epigenetic Silencing of AJAP1 on 1p36 in Glioblastoma[J]. MOLECULAR CANCER RESEARCH,2012,10(2):208-217.
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