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学科主题: 基础医学
题名:
Effect of sodium dimercaptopropanesulfonate on antagonism of tetramethylenedisulphotetramine to GABA receptor
作者: Zhang, CY; Zhu, TJ; Hu, GX; Chen, XY; Liu, DX; Chen, ZK
关键词: sodium dimercaptopropanesulfonate ; tetramethylenedisulphotetramine ; GABA receptors ; autoradiography
刊名: ACTA PHARMACOLOGICA SINICA
发表日期: 2001-05-01
卷: 22, 期:5, 页:435-439
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: GLUTATHIONE
英文摘要:

AIM: To study effects of sodium dimercaptopropanesulfonate (DMPS) on the antagonism of tetramethylenedisulphotetramine (TETS) to gamma -aminobutyric acid (GABA) receptor. METHODS: Acute toxicity experiments were conducted to observe the effects of DMPS and TETS on mice. Contents of free amino acids in mouse brain were determined with automatic analyzer for amino acids. Autoradiography was used to observe the [H-3]GABA bindings in the rat brain slices under different conditions. RESULTS: After icv and ip DMPS, the number of mice experiencing convulsions reduced from 20 in control group to 4 and 2 respectively in TETS poisoned mice. The content of GABA was altered in DMPS control group and TETS control group compared with DMPS protection group and NS control group [mu mol/g: (2.09 +/-0.05) and (2.61 +/- 0.15) vs (2.40 +/- 0.10 (mu mol/g)) and (2.41 +/- 0.21)]; the content of glutamic acid was (12.3 +/- 1.2), (12.0 +/- 0.8), (10.2 +/- 0.6), and (11.8 +/- 1.0) mu mol/g in NS control group, DMPS control group, TEIS control group, and DMPS protection group, respectively. The OD value of autoradiograms decreased in TETS group compared with buffer control group in cortex, hippocampus, diencephalon, and brainstem [(0.084 +/- 0.008), (0.081 +/- 0.009), (0.091 +/- 0.006) and (0.081 +/- 0.006), vs (0.102 +/- 0.003), (0.109 +/- 0.005), (0.128 +/- 0.007), and (0.125 +/- 0.008), respectively]. OD value was maintained or higher than the normal level in DMPS + TETS group in the four brain areas [(0.116 +/- 0.008), (0.125 +/- 0.011), (0.129 +/- 0.005), and (0.128 +/- 0.010) vs (0.102 +/- 0.003), (0.109 +/- 0.005), (0. 28 +/- 0.007), and (0.125 +/- 0.008), respectively]. CONCLUSION: The inhibitory effects of DMPS on the antagonism of TETS to GABA receptor are due to the increase in the GABA binding to its receptors in brain caused by DMPS.

语种: 英语
WOS记录号: WOS:000168479200010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54702
Appears in Collections:基础医学院_细胞生物学系_期刊论文

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作者单位: 1.Wenzhou Med Coll, Dept Pharmacol, Wenzhou 325027, Peoples R China
2.Beijing Med Univ, Dept Cell Biol, Beijing 100083, Peoples R China

Recommended Citation:
Zhang, CY,Zhu, TJ,Hu, GX,et al. Effect of sodium dimercaptopropanesulfonate on antagonism of tetramethylenedisulphotetramine to GABA receptor[J]. ACTA PHARMACOLOGICA SINICA,2001,22(5):435-439.
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