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学科主题: 药物依赖
题名:
PKM zeta Maintains Drug Reward and Aversion Memory in the Basolateral Amygdala and Extinction Memory in the Infralimbic Cortex
作者: He, Ying-Ying2,3; Xue, Yan-Xue3; Wang, Ji-shi1,2; Fang, Qin2; Liu, Jian-Feng3; Xue, Li-Fen3; Lu, Lin3
关键词: PKM zeta ; conditioned place preference ; conditioned place aversion ; memory ; amygdala ; infralimbic cortex
刊名: NEUROPSYCHOPHARMACOLOGY
发表日期: 2011-09-01
DOI: 10.1038/npp.2011.63
卷: 36, 期:10, 页:1972-1981
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]: Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]: LONG-TERM POTENTIATION ; KINASE M-ZETA ; VENTROMEDIAL PREFRONTAL CORTEX ; CONDITIONED-PLACE PREFERENCE ; POSTSYNAPTIC AMPA RECEPTORS ; NUCLEUS-ACCUMBENS CORE ; FEAR EXTINCTION ; SIGNALING PATHWAY ; NEURAL MECHANISMS ; PROTEIN-SYNTHESIS
英文摘要:

The intense associative memories that develop between drug-paired contextual cues and rewarding stimuli or the drug withdrawal-associated aversive feeling have been suggested to contribute to the high rate of relapse. Various studies have elucidated the mechanisms underlying the formation and expression of drug-related cue memories, but how this mechanism is maintained is unknown. Protein kinase M zeta (PKM zeta) was recently shown to be necessary and sufficient for long-term potentiation maintenance and memory storage. In the present study, we used conditioned place preference (CPP) and aversion (CPA) to examine whether PKM zeta maintains both morphine-associated reward memory and morphine withdrawal-associated aversive memory in the basolateral amygdala (BLA). We also investigate the role of PKM zeta in the infralimbic cortex in the extinction memory of morphine reward-related cues and morphine withdrawal-related aversive cues. We found that intra-BLA but not central nucleus of the amygdala injection of the selective PKM zeta inhibitor ZIP 1 day after CPP and CPA training impaired the expression of CPP and CPA 1 day later, and the effect of ZIP on memory lasted at least 2 weeks. Inhibiting PKMz activity in the infralimbic cortex, but not prelimbic cortex, disrupted the expression of the extinction memory of CPP and CPA. These results indicate that PKM zeta in the BLA is required for the maintenance of associative morphine reward memory and morphine withdrawal-associated aversion memory, and PKM zeta in the infralimbic cortex is required for the maintenance of extinction memory of morphine reward-related cues and morphine withdrawal-related aversive cues. Neuropsychopharmacology (2011) 36, 1972-1981; doi: 10.1038/npp. 2011.63; published online 1 June 2011

语种: 英语
所属项目编号: 2007CB512302 ; 30725016 ; 31070958 ; 2008-59
项目资助者: National Basic Research Program of China ; Natural Science Foundation of China ; Natural Science Foundation of Guizhou Province
WOS记录号: WOS:000293893100003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54709
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Guiyang Med Univ, Sch Pharm, Guiyang 550004, Peoples R China
2.Guiyang Med Univ, Affiliated Hosp, Guiyang Med Coll, Guiyang 550004, Peoples R China
3.Peking Univ, Natl Inst Drug Dependence, Beijing 100871, Peoples R China

Recommended Citation:
He, Ying-Ying,Xue, Yan-Xue,Wang, Ji-shi,et al. PKM zeta Maintains Drug Reward and Aversion Memory in the Basolateral Amygdala and Extinction Memory in the Infralimbic Cortex[J]. NEUROPSYCHOPHARMACOLOGY,2011,36(10):1972-1981.
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