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PKM zeta Maintains Drug Reward and Aversion Memory in the Basolateral Amygdala and Extinction Memory in the Infralimbic Cortex
He, Ying-Ying2,3; Xue, Yan-Xue3; Wang, Ji-shi1,2; Fang, Qin2; Liu, Jian-Feng3; Xue, Li-Fen3; Lu, Lin3
关键词Pkm Zeta Conditioned Place Preference Conditioned Place Aversion Memory Amygdala Infralimbic Cortex
刊名NEUROPSYCHOPHARMACOLOGY
2011-09-01
DOI10.1038/npp.2011.63
36期:10页:1972-1981
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]LONG-TERM POTENTIATION ; KINASE M-ZETA ; VENTROMEDIAL PREFRONTAL CORTEX ; CONDITIONED-PLACE PREFERENCE ; POSTSYNAPTIC AMPA RECEPTORS ; NUCLEUS-ACCUMBENS CORE ; FEAR EXTINCTION ; SIGNALING PATHWAY ; NEURAL MECHANISMS ; PROTEIN-SYNTHESIS
英文摘要

The intense associative memories that develop between drug-paired contextual cues and rewarding stimuli or the drug withdrawal-associated aversive feeling have been suggested to contribute to the high rate of relapse. Various studies have elucidated the mechanisms underlying the formation and expression of drug-related cue memories, but how this mechanism is maintained is unknown. Protein kinase M zeta (PKM zeta) was recently shown to be necessary and sufficient for long-term potentiation maintenance and memory storage. In the present study, we used conditioned place preference (CPP) and aversion (CPA) to examine whether PKM zeta maintains both morphine-associated reward memory and morphine withdrawal-associated aversive memory in the basolateral amygdala (BLA). We also investigate the role of PKM zeta in the infralimbic cortex in the extinction memory of morphine reward-related cues and morphine withdrawal-related aversive cues. We found that intra-BLA but not central nucleus of the amygdala injection of the selective PKM zeta inhibitor ZIP 1 day after CPP and CPA training impaired the expression of CPP and CPA 1 day later, and the effect of ZIP on memory lasted at least 2 weeks. Inhibiting PKMz activity in the infralimbic cortex, but not prelimbic cortex, disrupted the expression of the extinction memory of CPP and CPA. These results indicate that PKM zeta in the BLA is required for the maintenance of associative morphine reward memory and morphine withdrawal-associated aversion memory, and PKM zeta in the infralimbic cortex is required for the maintenance of extinction memory of morphine reward-related cues and morphine withdrawal-related aversive cues. Neuropsychopharmacology (2011) 36, 1972-1981; doi: 10.1038/npp. 2011.63; published online 1 June 2011

语种英语
WOS记录号WOS:000293893100003
Citation statistics
Cited Times:41[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54709
Collection中国药物依赖性研究所
作者单位1.Guiyang Med Univ, Sch Pharm, Guiyang 550004, Peoples R China
2.Guiyang Med Univ, Affiliated Hosp, Guiyang Med Coll, Guiyang 550004, Peoples R China
3.Peking Univ, Natl Inst Drug Dependence, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
He, Ying-Ying,Xue, Yan-Xue,Wang, Ji-shi,et al. PKM zeta Maintains Drug Reward and Aversion Memory in the Basolateral Amygdala and Extinction Memory in the Infralimbic Cortex[J]. NEUROPSYCHOPHARMACOLOGY,2011,36(10):1972-1981.
APA He, Ying-Ying.,Xue, Yan-Xue.,Wang, Ji-shi.,Fang, Qin.,Liu, Jian-Feng.,...&Lu, Lin.(2011).PKM zeta Maintains Drug Reward and Aversion Memory in the Basolateral Amygdala and Extinction Memory in the Infralimbic Cortex.NEUROPSYCHOPHARMACOLOGY,36(10),1972-1981.
MLA He, Ying-Ying,et al."PKM zeta Maintains Drug Reward and Aversion Memory in the Basolateral Amygdala and Extinction Memory in the Infralimbic Cortex".NEUROPSYCHOPHARMACOLOGY 36.10(2011):1972-1981.
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