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学科主题: 口腔医学
题名:
Activation of Toll-like receptor 9 inhibits lipopolysaccharide-induced receptor activator of nuclear factor kappa- B ligand expression in rat B lymphocytes
作者: Yu, Xiaoqian1,2; Lin, Jiang1,3; Yu, Qing1; Kawai, Toshihisa1; Taubman, Martin A.1; Han, Xiaozhe1
关键词: RANK ligand ; Toll-like receptor ; B lymphocytes ; immune response
刊名: MICROBIOLOGY AND IMMUNOLOGY
发表日期: 2014
DOI: 10.1111/1348-0421.12115
卷: 58, 期:1, 页:51-60
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology ; Microbiology
研究领域[WOS]: Immunology ; Microbiology
关键词[WOS]: RHEUMATOID SYNOVIAL FIBROBLASTS ; CPG-OLIGODEOXYNUCLEOTIDES ; OSTEOCLASTOGENIC ACTIVITY ; PORPHYROMONAS-GINGIVALIS ; PERIODONTAL-DISEASE ; GROWTH-FACTOR ; BONE-RESORPTION ; T-CELLS ; RANKL ; APOPTOSIS
英文摘要:

B lymphocytes express multiple TLRs that regulate their cytokine production. We investigated the effect of TLR4 and TLR9 activation on receptor activator of NF-kappa B ligand (RANKL) expression by rat spleen B cells. Splenocytes or purified spleen B cells from Rowett rats were cultured with TLR4 ligand Escherichia coli LPS and/or TLR9 ligand CpG-oligodeoxynucleotide (CpG-ODN) for 2 days. RANKL mRNA expression and the percentage of RANKL-positive B cells were increased in rat splenocytes challenged by E. coli LPS alone. The increases were less pronounced when cells were treated with both CpG-ODN and E. coli LPS. Microarray analysis showed that expressions of multiple cyclin-dependent kinase (CDK) pathway-related genes were up-regulated only in cells treated with both E. coli LPS and CpG-ODN. This study suggests that CpG-ODN inhibits LPS-induced RANKL expression in rat B cells via regulation of the CDK pathway.

语种: 英语
所属项目编号: DE-003420 ; DE-021837
项目资助者: NIH from the National Institute of Dental and Craniofacial Research
WOS记录号: WOS:000333663500007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54713
Appears in Collections:北京大学口腔医学院_牙周科_期刊论文

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作者单位: 1.Forsyth Inst, Dept Immunol & Infect Dis, Cambridge, MA 02142 USA
2.Peking Univ Sch & Hosp Stomatol, Dept Periodontol, Beijing 100081, Peoples R China
3.Harbin Med Univ, Hosp 4, Dept Stomatol, Harbin 150001, Peoples R China

Recommended Citation:
Yu, Xiaoqian,Lin, Jiang,Yu, Qing,et al. Activation of Toll-like receptor 9 inhibits lipopolysaccharide-induced receptor activator of nuclear factor kappa- B ligand expression in rat B lymphocytes[J]. MICROBIOLOGY AND IMMUNOLOGY,2014,58(1):51-60.
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