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学科主题口腔医学
Activation of Toll-like receptor 9 inhibits lipopolysaccharide-induced receptor activator of nuclear factor kappa- B ligand expression in rat B lymphocytes
Yu, Xiaoqian1,2; Lin, Jiang1,3; Yu, Qing1; Kawai, Toshihisa1; Taubman, Martin A.1; Han, Xiaozhe1
关键词Rank Ligand Toll-like Receptor b Lymphocytes Immune Response
刊名MICROBIOLOGY AND IMMUNOLOGY
2014
DOI10.1111/1348-0421.12115
58期:1页:51-60
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology ; Microbiology
研究领域[WOS]Immunology ; Microbiology
关键词[WOS]RHEUMATOID SYNOVIAL FIBROBLASTS ; CPG-OLIGODEOXYNUCLEOTIDES ; OSTEOCLASTOGENIC ACTIVITY ; PORPHYROMONAS-GINGIVALIS ; PERIODONTAL-DISEASE ; GROWTH-FACTOR ; BONE-RESORPTION ; T-CELLS ; RANKL ; APOPTOSIS
英文摘要

B lymphocytes express multiple TLRs that regulate their cytokine production. We investigated the effect of TLR4 and TLR9 activation on receptor activator of NF-kappa B ligand (RANKL) expression by rat spleen B cells. Splenocytes or purified spleen B cells from Rowett rats were cultured with TLR4 ligand Escherichia coli LPS and/or TLR9 ligand CpG-oligodeoxynucleotide (CpG-ODN) for 2 days. RANKL mRNA expression and the percentage of RANKL-positive B cells were increased in rat splenocytes challenged by E. coli LPS alone. The increases were less pronounced when cells were treated with both CpG-ODN and E. coli LPS. Microarray analysis showed that expressions of multiple cyclin-dependent kinase (CDK) pathway-related genes were up-regulated only in cells treated with both E. coli LPS and CpG-ODN. This study suggests that CpG-ODN inhibits LPS-induced RANKL expression in rat B cells via regulation of the CDK pathway.

语种英语
WOS记录号WOS:000333663500007
项目编号DE-003420 ; DE-021837
资助机构NIH from the National Institute of Dental and Craniofacial Research
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54713
专题北京大学口腔医学院_牙周科
作者单位1.Forsyth Inst, Dept Immunol & Infect Dis, Cambridge, MA 02142 USA
2.Peking Univ Sch & Hosp Stomatol, Dept Periodontol, Beijing 100081, Peoples R China
3.Harbin Med Univ, Hosp 4, Dept Stomatol, Harbin 150001, Peoples R China
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GB/T 7714
Yu, Xiaoqian,Lin, Jiang,Yu, Qing,et al. Activation of Toll-like receptor 9 inhibits lipopolysaccharide-induced receptor activator of nuclear factor kappa- B ligand expression in rat B lymphocytes[J]. MICROBIOLOGY AND IMMUNOLOGY,2014,58(1):51-60.
APA Yu, Xiaoqian,Lin, Jiang,Yu, Qing,Kawai, Toshihisa,Taubman, Martin A.,&Han, Xiaozhe.(2014).Activation of Toll-like receptor 9 inhibits lipopolysaccharide-induced receptor activator of nuclear factor kappa- B ligand expression in rat B lymphocytes.MICROBIOLOGY AND IMMUNOLOGY,58(1),51-60.
MLA Yu, Xiaoqian,et al."Activation of Toll-like receptor 9 inhibits lipopolysaccharide-induced receptor activator of nuclear factor kappa- B ligand expression in rat B lymphocytes".MICROBIOLOGY AND IMMUNOLOGY 58.1(2014):51-60.
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