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学科主题: 口腔医学
题名:
In situ synthesis and biocompatibility of nano hydroxyapatite on pristine and chitosan functionalized graphene oxide
作者: Li, Ming1; Wang, Yanbo2; Liu, Qian1; Li, Qiuhong1; Cheng, Yan1; Zheng, Yufeng1,3; Xi, Tingfei1; Wei, Shicheng1,4
刊名: JOURNAL OF MATERIALS CHEMISTRY B
发表日期: 2013
DOI: 10.1039/c2tb00053a
卷: 1, 期:4, 页:475-484
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Materials Science, Biomaterials
研究领域[WOS]: Materials Science
关键词[WOS]: MECHANICAL-PROPERTIES ; CARBON NANOTUBES ; SURFACE FUNCTIONALIZATION ; COMPOSITES ; NANOCOMPOSITES ; OSTEOBLASTS ; NANOSTRUCTURES ; NANOPARTICLES ; FABRICATION ; BEHAVIOR
英文摘要:

Motivated by the success of using graphene oxide (GO) as a nanofiller of composites, there is a drive to search for this new kind of carbon material as a reinforcing phase in biocomposites. In the present work, graphene oxide and chitosan (CS) functionalized graphene oxide were introduced as templates to fabricate hydroxyapatite (HA) using a facile solution-based in situ synthesis method, and GO-HA and CS-GO-HA nanocomposites were successfully prepared for the first time. It was found that the spindle like HA nanoparticles with a diameter of about 27 +/- 7 nm and a length around 150 +/- 25 nm were decorated randomly and strongly on the surface or aggregated at the edges of the pristine and chitosan functionalized GO matrix. Compared with HA, the prepared GO-based HA nanocomposites displayed an increased elastic modulus and hardness. The in vitro cytotoxicity of the prepared nanocomposites was investigated using CCK-8 assay on murine fibroblast L-929 cell line and human osteoblast-like MG-63 cell line, respectively. Both of the nanocomposites exhibited a high cell proliferation rate for L-929 and MG-63, and the CS-GO-HA could provide significantly higher cell viability and alkaline phosphatase activity compared to the GO-HA composite. These findings may provide new prospects for utilizing the GO-based hydroxyapatite biocomposites in bone repair, bone augmentation, as well as coating of biomedical implants and broaden the application of GO sheets in biological areas.

语种: 英语
所属项目编号: 2011AA030103 ; 2009CB930004 ; 2012CB619102 ; 31070846 ; 30870623
项目资助者: National High Technology Research and Development Program of China ; National Basic Research Program (973) of China ; National Natural Science Foundation of China
WOS记录号: WOS:000314788600009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54714
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: 1.Peking Univ, Acad Adv Interdisciplinary Studies, Ctr Biomed Mat & Tissue Engn, Beijing 100871, Peoples R China
2.Angstron Mat LLC, Dayton, OH 45404 USA
3.Peking Univ, Coll Engn, Dept Mat Sci & Engn, Beijing 100871, Peoples R China
4.Peking Univ, Sch Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100871, Peoples R China

Recommended Citation:
Li, Ming,Wang, Yanbo,Liu, Qian,et al. In situ synthesis and biocompatibility of nano hydroxyapatite on pristine and chitosan functionalized graphene oxide[J]. JOURNAL OF MATERIALS CHEMISTRY B,2013,1(4):475-484.
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