IR@PKUHSC  > 北京大学口腔医学院
学科主题口腔医学
In situ synthesis and biocompatibility of nano hydroxyapatite on pristine and chitosan functionalized graphene oxide
Li, Ming1; Wang, Yanbo2; Liu, Qian1; Li, Qiuhong1; Cheng, Yan1; Zheng, Yufeng1,3; Xi, Tingfei1; Wei, Shicheng1,4
刊名JOURNAL OF MATERIALS CHEMISTRY B
2013
DOI10.1039/c2tb00053a
1期:4页:475-484
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Materials Science, Biomaterials
研究领域[WOS]Materials Science
关键词[WOS]MECHANICAL-PROPERTIES ; CARBON NANOTUBES ; SURFACE FUNCTIONALIZATION ; COMPOSITES ; NANOCOMPOSITES ; OSTEOBLASTS ; NANOSTRUCTURES ; NANOPARTICLES ; FABRICATION ; BEHAVIOR
英文摘要

Motivated by the success of using graphene oxide (GO) as a nanofiller of composites, there is a drive to search for this new kind of carbon material as a reinforcing phase in biocomposites. In the present work, graphene oxide and chitosan (CS) functionalized graphene oxide were introduced as templates to fabricate hydroxyapatite (HA) using a facile solution-based in situ synthesis method, and GO-HA and CS-GO-HA nanocomposites were successfully prepared for the first time. It was found that the spindle like HA nanoparticles with a diameter of about 27 +/- 7 nm and a length around 150 +/- 25 nm were decorated randomly and strongly on the surface or aggregated at the edges of the pristine and chitosan functionalized GO matrix. Compared with HA, the prepared GO-based HA nanocomposites displayed an increased elastic modulus and hardness. The in vitro cytotoxicity of the prepared nanocomposites was investigated using CCK-8 assay on murine fibroblast L-929 cell line and human osteoblast-like MG-63 cell line, respectively. Both of the nanocomposites exhibited a high cell proliferation rate for L-929 and MG-63, and the CS-GO-HA could provide significantly higher cell viability and alkaline phosphatase activity compared to the GO-HA composite. These findings may provide new prospects for utilizing the GO-based hydroxyapatite biocomposites in bone repair, bone augmentation, as well as coating of biomedical implants and broaden the application of GO sheets in biological areas.

语种英语
WOS记录号WOS:000314788600009
项目编号2011AA030103 ; 2009CB930004 ; 2012CB619102 ; 31070846 ; 30870623
资助机构National High Technology Research and Development Program of China ; National Basic Research Program (973) of China ; National Natural Science Foundation of China
引用统计
被引频次:111[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54714
专题北京大学口腔医学院
北京大学第一临床医学院_急诊科
作者单位1.Peking Univ, Acad Adv Interdisciplinary Studies, Ctr Biomed Mat & Tissue Engn, Beijing 100871, Peoples R China
2.Angstron Mat LLC, Dayton, OH 45404 USA
3.Peking Univ, Coll Engn, Dept Mat Sci & Engn, Beijing 100871, Peoples R China
4.Peking Univ, Sch Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100871, Peoples R China
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GB/T 7714
Li, Ming,Wang, Yanbo,Liu, Qian,et al. In situ synthesis and biocompatibility of nano hydroxyapatite on pristine and chitosan functionalized graphene oxide[J]. JOURNAL OF MATERIALS CHEMISTRY B,2013,1(4):475-484.
APA Li, Ming.,Wang, Yanbo.,Liu, Qian.,Li, Qiuhong.,Cheng, Yan.,...&Wei, Shicheng.(2013).In situ synthesis and biocompatibility of nano hydroxyapatite on pristine and chitosan functionalized graphene oxide.JOURNAL OF MATERIALS CHEMISTRY B,1(4),475-484.
MLA Li, Ming,et al."In situ synthesis and biocompatibility of nano hydroxyapatite on pristine and chitosan functionalized graphene oxide".JOURNAL OF MATERIALS CHEMISTRY B 1.4(2013):475-484.
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