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学科主题: 药学
题名:
Concise Syntheses of Trifluoromethylated Cyclic and Acyclic Analogues of cADPR
作者: Huang, Xiangchen; Dong, Min; Liu, Jian; Zhang, Kehui; Yang, Zhenjun; Zhang, Liangren; Zhang, Lihe
关键词: cADPR analogue ; acyclic cADPR analogue ; trifluoromethylation ; synthesis
刊名: MOLECULES
发表日期: 2010-12-01
DOI: 10.3390/molecules15128689
卷: 15, 期:12, 页:8689-8701
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: ADP-RIBOSE ; BIOLOGICAL EVALUATION ; CALCIUM-RELEASE ; CHEMISTRY ; DERIVATIVES ; CONVENIENT ; LINKAGE ; MIMICS
英文摘要:

A novel trifluoromethylated analogue of cADPR, 8-CF(3)-cIDPDE (5) was designed and synthesized via construction of N(1), N(9)-disubstituted hypoxanthine, trifluoromethylation and intramolecular condensation. A series of acyclic analogues of cADPR were also designed and synthesized. These compounds could be useful molecules for studying the structure-activity relationship of cADPR analogues and exploring the cADPR/RyR Ca(2+) signalling system.

语种: 英语
所属项目编号: 90713005 ; 20832008 ; 200800010078
项目资助者: National Natural Sciences Foundation of China ; Ministry of Education of China
WOS记录号: WOS:000285709000010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54720
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Huang, Xiangchen,Dong, Min,Liu, Jian,et al. Concise Syntheses of Trifluoromethylated Cyclic and Acyclic Analogues of cADPR[J]. MOLECULES,2010,15(12):8689-8701.
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