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学科主题: 基础医学
题名:
Interleukin-1 beta is involved in the pressor response of amygdaloid neurons excited by sodium glutamate
作者: Lu, Y; Chen, W; Zou, CJ
关键词: arcuate nucleus ; central amygdaloid nucleus ; interleukin-1 beta ; paraventricular nucleus
刊名: NEUROREPORT
发表日期: 2002-03-25
卷: 13, 期:4, 页:559-562
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: NUCLEUS
英文摘要:

The effects of interleukin-1beta in the paraventricular nucleus or caudal arcuate nucleus on hypertensive and tachycardiac responses induced by excitation of the central amygdaloid nucleus were studied. We observed that microinjection of sodium glutamate into central amygdaloid nucleus resulted in hypertension and tachycardia. Microinjection of interleukin-1beta into paraventricular nucleus or caudal arcuate nucleus induced significant pressor and tachycardiac responses while pretreatment with microinjection of rabbit anti-rat interleukin-1beta antibody into bilateral paraventricular nuclei or arcuate nuclei attenuated the hypertensive response induced by microinjection of 40 nmol sodium glutamate into central amygdaloid nucleus. The above results suggest that the pressor effect of central amygdaloid nucleus is mediated by interleukin-1beta in paraventricular nucleus or arcuate nucleus.

语种: 英语
WOS记录号: WOS:000174971300039
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54724
Appears in Collections:基础医学院_生理学与病理生理学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Physiol, Beijing 100083, Peoples R China
2.Peking Univ, Inst Cardiovasc Res, Beijing 100083, Peoples R China

Recommended Citation:
Lu, Y,Chen, W,Zou, CJ. Interleukin-1 beta is involved in the pressor response of amygdaloid neurons excited by sodium glutamate[J]. NEUROREPORT,2002,13(4):559-562.
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