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学科主题: 药学
题名:
Characterization of a carcinogenesis-associated long non-coding RNA
作者: Yang, Feng1; Yi, Fan1; Zheng, Zhiguo2; Ling, Zhiqiang2; Ding, Jianv3; Guo, Jiangfeng3; Mao, Weimin2; Wang, Xiongbiao4; Wang, Xiaoxia1; Ding, Xianfeng3; Liang, Zicai1; Du, Quan5
关键词: long non-coding RNA ; cell cycle ; tumor
刊名: RNA BIOLOGY
发表日期: 2012
DOI: 10.4161/rna.9.1.18332
卷: 9, 期:1, 页:110-116
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: BREAST-CANCER ; PROX1 FUNCTION ; HUMAN GENOME ; CELL-LINES ; GENE ; METAANALYSIS ; EXPRESSION ; SYSTEM ; DNA
英文摘要:

A negative selection strategy was used in the present study to isolate long polyA-minus RNAs from the total transcriptome and a long non-coding RNA named Yiya was identified. Yiya is a 1.9 kb long intergenic ncRNA gene mapped to chromosome 1q41, a well-established cancer susceptibility locus. Expression profiling revealed a general and regulated expression pattern of Yiya in major tissues, and more interestingly, identified elevated mRNA levels in different cancers. Quantitative analysis further demonstrated a dynamic regulation of Yiya expression in cell cycle progression, suggesting that it was involved in cell cycle regulation. Supporting this, overexpression of Yiya promotes cell cycle progression at the G1/S transition, therefore identifying Yiya as a cell-cycle-associated long non-coding RNA.

语种: 英语
所属项目编号: 2007AA02Z165 ; 2011CBA01102 ; 2007CB512100 ; 30873187 ; 30771085 ; 30871385 ; Y2100681
项目资助者: National High-tech R&amp ; D Program of China ; National Basic Research Program of China ; National Natural Science Foundation of China ; Zhejiang Natural Science Foundation ; Zhejiang Open Foundation of the Most Important Subjects
WOS记录号: WOS:000300225100015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54726
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Inst Mol Med, Beijing 100871, Peoples R China
2.Zhejiang Prov Canc Hosp, Zhejiang Canc Res Inst, Hangzhou, Zhejiang, Peoples R China
3.Zhejiang Sci Tech Univ, Sch Life Sci, Hangzhou, Zhejiang, Peoples R China
4.Shanghai Univ Tradit Med, Putuo Hosp, Shanghai, Peoples R China
5.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China

Recommended Citation:
Yang, Feng,Yi, Fan,Zheng, Zhiguo,et al. Characterization of a carcinogenesis-associated long non-coding RNA[J]. RNA BIOLOGY,2012,9(1):110-116.
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