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Characterization of a carcinogenesis-associated long non-coding RNA
Yang, Feng1; Yi, Fan1; Zheng, Zhiguo2; Ling, Zhiqiang2; Ding, Jianv3; Guo, Jiangfeng3; Mao, Weimin2; Wang, Xiongbiao4; Wang, Xiaoxia1; Ding, Xianfeng3; Liang, Zicai1; Du, Quan5
关键词Long Non-coding Rna Cell Cycle Tumor
刊名RNA BIOLOGY
2012
DOI10.4161/rna.9.1.18332
9期:1页:110-116
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]BREAST-CANCER ; PROX1 FUNCTION ; HUMAN GENOME ; CELL-LINES ; GENE ; METAANALYSIS ; EXPRESSION ; SYSTEM ; DNA
英文摘要

A negative selection strategy was used in the present study to isolate long polyA-minus RNAs from the total transcriptome and a long non-coding RNA named Yiya was identified. Yiya is a 1.9 kb long intergenic ncRNA gene mapped to chromosome 1q41, a well-established cancer susceptibility locus. Expression profiling revealed a general and regulated expression pattern of Yiya in major tissues, and more interestingly, identified elevated mRNA levels in different cancers. Quantitative analysis further demonstrated a dynamic regulation of Yiya expression in cell cycle progression, suggesting that it was involved in cell cycle regulation. Supporting this, overexpression of Yiya promotes cell cycle progression at the G1/S transition, therefore identifying Yiya as a cell-cycle-associated long non-coding RNA.

语种英语
WOS记录号WOS:000300225100015
项目编号2007AA02Z165 ; 2011CBA01102 ; 2007CB512100 ; 30873187 ; 30771085 ; 30871385 ; Y2100681
资助机构National High-tech R&amp ; D Program of China ; National Basic Research Program of China ; National Natural Science Foundation of China ; Zhejiang Natural Science Foundation ; Zhejiang Open Foundation of the Most Important Subjects
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54726
专题北京大学药学院
作者单位1.Peking Univ, Inst Mol Med, Beijing 100871, Peoples R China
2.Zhejiang Prov Canc Hosp, Zhejiang Canc Res Inst, Hangzhou, Zhejiang, Peoples R China
3.Zhejiang Sci Tech Univ, Sch Life Sci, Hangzhou, Zhejiang, Peoples R China
4.Shanghai Univ Tradit Med, Putuo Hosp, Shanghai, Peoples R China
5.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Yang, Feng,Yi, Fan,Zheng, Zhiguo,et al. Characterization of a carcinogenesis-associated long non-coding RNA[J]. RNA BIOLOGY,2012,9(1):110-116.
APA Yang, Feng.,Yi, Fan.,Zheng, Zhiguo.,Ling, Zhiqiang.,Ding, Jianv.,...&Du, Quan.(2012).Characterization of a carcinogenesis-associated long non-coding RNA.RNA BIOLOGY,9(1),110-116.
MLA Yang, Feng,et al."Characterization of a carcinogenesis-associated long non-coding RNA".RNA BIOLOGY 9.1(2012):110-116.
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