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Metabolism of Hibifolin by Human Intestinal Bacteria
Xu, Tong-Tong; Yang, Xiu-Wei; Wang, Bin; Xu, Wei; Zhao, Yu-Ying; Zhang, Qing-Ying1
关键词Hibifolin Human Intestinal Bacteria Metabolites Gossypetin 8-o-beta-d-4 &Prime &Prime -deoxy-delta 4 &Prime &Prime -glucuropyranoside Abelmoschus Manihot Malvaceae
刊名PLANTA MEDICA
2009-04-01
DOI10.1055/s-0029-1185317
75期:5页:483-487
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]FLAVONOIDS ; FLORA
英文摘要

Hibifolin, the highest-content bioactive flavonoid of the flowers of Abelmoschus manihot, was incubated with human intestinal bacteria, and four metabolites (1-4) were obtained from the incubated solution by chromatographic methods. The structures of the four metabolites were elucidated as gossypetin 8-O-beta-D-4"-deoxy-Delta 4"-glucuropyranoside (1), gossypetin (2), quercetin (3), and 8-methoxy-quercetin (4), respectively, on the basis of UV, NMR, and MS data. Metabolite 1 was obtained as a new compound with a specific beta-D-4"-deoxy-Delta 4"-glucuropyranosyl moiety, which was formed through a unique and novel metabolic pathway that has not been reported previously.

语种英语
WOS记录号WOS:000265486100005
项目编号20432030 ; 20742005 ; 985-2-063-112
资助机构National Natural Science Foundation of China ; Program Changjiang Scholar and Innovative Team in University
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54745
专题北京大学药学院_天然药物学系
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Nat Med, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Xu, Tong-Tong,Yang, Xiu-Wei,Wang, Bin,et al. Metabolism of Hibifolin by Human Intestinal Bacteria[J]. PLANTA MEDICA,2009,75(5):483-487.
APA Xu, Tong-Tong,Yang, Xiu-Wei,Wang, Bin,Xu, Wei,Zhao, Yu-Ying,&Zhang, Qing-Ying.(2009).Metabolism of Hibifolin by Human Intestinal Bacteria.PLANTA MEDICA,75(5),483-487.
MLA Xu, Tong-Tong,et al."Metabolism of Hibifolin by Human Intestinal Bacteria".PLANTA MEDICA 75.5(2009):483-487.
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