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学科主题: 药学
题名:
Metabolism of Hibifolin by Human Intestinal Bacteria
作者: Xu, Tong-Tong; Yang, Xiu-Wei; Wang, Bin; Xu, Wei; Zhao, Yu-Ying; Zhang, Qing-Ying1
关键词: hibifolin ; human intestinal bacteria ; metabolites ; gossypetin 8-O-beta-D-4 &prime ; &prime ; -deoxy-Delta 4 &prime ; &prime ; -glucuropyranoside ; Abelmoschus manihot ; Malvaceae
刊名: PLANTA MEDICA
发表日期: 2009-04-01
DOI: 10.1055/s-0029-1185317
卷: 75, 期:5, 页:483-487
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]: FLAVONOIDS ; FLORA
英文摘要:

Hibifolin, the highest-content bioactive flavonoid of the flowers of Abelmoschus manihot, was incubated with human intestinal bacteria, and four metabolites (1-4) were obtained from the incubated solution by chromatographic methods. The structures of the four metabolites were elucidated as gossypetin 8-O-beta-D-4"-deoxy-Delta 4"-glucuropyranoside (1), gossypetin (2), quercetin (3), and 8-methoxy-quercetin (4), respectively, on the basis of UV, NMR, and MS data. Metabolite 1 was obtained as a new compound with a specific beta-D-4"-deoxy-Delta 4"-glucuropyranosyl moiety, which was formed through a unique and novel metabolic pathway that has not been reported previously.

语种: 英语
所属项目编号: 20432030 ; 20742005 ; 985-2-063-112
项目资助者: National Natural Science Foundation of China ; Program Changjiang Scholar and Innovative Team in University
WOS记录号: WOS:000265486100005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54745
Appears in Collections:北京大学药学院_天然药物学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Nat Med, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China

Recommended Citation:
Xu, Tong-Tong,Yang, Xiu-Wei,Wang, Bin,et al. Metabolism of Hibifolin by Human Intestinal Bacteria[J]. PLANTA MEDICA,2009,75(5):483-487.
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