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学科主题: 临床医学
题名:
Relationship between osteopenia and lumbar intervertebral disc degeneration in ovariectomized rats
作者: Wang, T; Zhang, L; Huang, C; Cheng, AG; Dang, GT
关键词: osteopenia ; intervertebral disc ; degeneration ; ovariectomy
刊名: CALCIFIED TISSUE INTERNATIONAL
发表日期: 2004-09-01
DOI: 10.1007/s00223-004-0240-8
卷: 75, 期:3, 页:205-213
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: BONE-MINERAL DENSITY ; VERTEBRAL BONE ; RISK-FACTORS ; END-PLATE ; IN-VITRO ; OSTEOPOROSIS ; OSTEOARTHRITIS ; CARTILAGE ; WOMEN ; SPINE
英文摘要:

Ovariectomy (OVX) can cause bone loss in rats, but little is known about how it also induces turn-bar intervertebral disc degeneration (LVD). This study investigated how estrogen deficiency affected intervertebral discs in OVX rats. Thirty 3-month-old female Sprague-Dawley rats were divided randomly into three equal groups. The baseline control group (BL) was killed at the beginning of the experiment. An ovariectomy was performed in 10 rats (OVX group) and another group of 10 rats was subjected to a sham surgery (Sham group). The OVX rats were untreated after the surgery to allow for the development of moderate osteopenia. Bone mineral density (BMD) measurement and bone histomorphometric analysis were applied to the segments of lumbar spines in all rats killed 6 months after surgery. The pathological changes of intervertebral discs were observed and the degree of LVD was scored by a histological scoring system. The BMD of the spines (L3-L5) in the OVX group decreased significantly compared with the Sham group. The bone volume indices in the OVX group were significantly lower, but the bone turnover rate parameters were significantly higher than those in the Sham group (P < 0.01). The histological scores for LVD in the OVX group were significantly higher than those in the Sham group (P < 0.01). There Was a significant negative correlation between the BMD and Grade II discs in the OVX rats (P = 0.042). In conclusion, LVD occurs in the OVX rats and the degeneration of cartilage end plates may be a pathogenic factor in disc degeneration.

语种: 英语
WOS记录号: WOS:000223982800004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54746
Appears in Collections:北京大学第三临床医学院_骨科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Orthopaed Surg, Beijing 100083, Peoples R China
2.N China Coal Med Coll, Affiliated Hosp, Dept Orthopaed Surg, Tangshan 063000, Peoples R China
3.Yan Tai Shan Hosp, Dept Orthopaed Surg, Yantai 264001, Peoples R China

Recommended Citation:
Wang, T,Zhang, L,Huang, C,et al. Relationship between osteopenia and lumbar intervertebral disc degeneration in ovariectomized rats[J]. CALCIFIED TISSUE INTERNATIONAL,2004,75(3):205-213.
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