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Relationship between osteopenia and lumbar intervertebral disc degeneration in ovariectomized rats
Wang, T; Zhang, L; Huang, C; Cheng, AG; Dang, GT
关键词Osteopenia Intervertebral Disc Degeneration Ovariectomy
刊名CALCIFIED TISSUE INTERNATIONAL
2004-09-01
DOI10.1007/s00223-004-0240-8
75期:3页:205-213
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism
研究领域[WOS]Endocrinology & Metabolism
关键词[WOS]BONE-MINERAL DENSITY ; VERTEBRAL BONE ; RISK-FACTORS ; END-PLATE ; IN-VITRO ; OSTEOPOROSIS ; OSTEOARTHRITIS ; CARTILAGE ; WOMEN ; SPINE
英文摘要

Ovariectomy (OVX) can cause bone loss in rats, but little is known about how it also induces turn-bar intervertebral disc degeneration (LVD). This study investigated how estrogen deficiency affected intervertebral discs in OVX rats. Thirty 3-month-old female Sprague-Dawley rats were divided randomly into three equal groups. The baseline control group (BL) was killed at the beginning of the experiment. An ovariectomy was performed in 10 rats (OVX group) and another group of 10 rats was subjected to a sham surgery (Sham group). The OVX rats were untreated after the surgery to allow for the development of moderate osteopenia. Bone mineral density (BMD) measurement and bone histomorphometric analysis were applied to the segments of lumbar spines in all rats killed 6 months after surgery. The pathological changes of intervertebral discs were observed and the degree of LVD was scored by a histological scoring system. The BMD of the spines (L3-L5) in the OVX group decreased significantly compared with the Sham group. The bone volume indices in the OVX group were significantly lower, but the bone turnover rate parameters were significantly higher than those in the Sham group (P < 0.01). The histological scores for LVD in the OVX group were significantly higher than those in the Sham group (P < 0.01). There Was a significant negative correlation between the BMD and Grade II discs in the OVX rats (P = 0.042). In conclusion, LVD occurs in the OVX rats and the degeneration of cartilage end plates may be a pathogenic factor in disc degeneration.

语种英语
WOS记录号WOS:000223982800004
引用统计
被引频次:32[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54746
专题北京大学第三临床医学院_骨科
作者单位1.Peking Univ, Hosp 3, Dept Orthopaed Surg, Beijing 100083, Peoples R China
2.N China Coal Med Coll, Affiliated Hosp, Dept Orthopaed Surg, Tangshan 063000, Peoples R China
3.Yan Tai Shan Hosp, Dept Orthopaed Surg, Yantai 264001, Peoples R China
推荐引用方式
GB/T 7714
Wang, T,Zhang, L,Huang, C,et al. Relationship between osteopenia and lumbar intervertebral disc degeneration in ovariectomized rats[J]. CALCIFIED TISSUE INTERNATIONAL,2004,75(3):205-213.
APA Wang, T,Zhang, L,Huang, C,Cheng, AG,&Dang, GT.(2004).Relationship between osteopenia and lumbar intervertebral disc degeneration in ovariectomized rats.CALCIFIED TISSUE INTERNATIONAL,75(3),205-213.
MLA Wang, T,et al."Relationship between osteopenia and lumbar intervertebral disc degeneration in ovariectomized rats".CALCIFIED TISSUE INTERNATIONAL 75.3(2004):205-213.
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