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学科主题: 临床医学
题名:
Taurine protected myocardial mitochondria injury induced by hyperhomocysteinemia in rats
作者: Chang, L; Xu, J; Yu, F; Zhao, J; Tang, X; Tang, C
关键词: hyperhomocysteine ; taurine ; heart ; mitochondria ; rat
刊名: AMINO ACIDS
发表日期: 2004-08-01
DOI: 10.1007/s00726-004-0096-2
卷: 27, 期:1, 页:37-48
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: OXIDATIVE STRESS ; CARDIOVASCULAR-DISEASE ; HOMOCYSTEINE ; PLASMA ; SUPEROXIDE ; INHIBITION ; EXPRESSION ; AORTA ; CELLS ; SECRETION
英文摘要:

Taurine can protect against cardiovascular diseases, whereas elevated levels of plasma homocysteine are associated with atherosclerotic and thromboembolic cardiovascular diseases. To illustrate the effects of taurine on hyperhomocysteinemia, we observed the myocardial mitochondria dysfunction in the rats with hyperhomocysteinemia induced by diet methionine loading, and the therapeutic effect of taurine. A methionine diet increased plasma homocysteine concentration (133.51 +/- 27.91 mumol/L vs 12.31 +/- 2.58 mumol/L in control, P < 0.01), stimulated the production of reactive oxygen species (ROS) in the myocardial mitochondria, and inhibited the activities of mitochondrial Mn-superoxide dismutase and catalase. The Ca-45 uptake and Ca2+-ATPase activity in the myocardial mitochondria were significantly lowered in rats with hyperhomocysteinemia. Taurine supplements effectively attenuated the hyperhomocysteinemia-induced ROS production and inhibition of Mn-superoxide dismutase and catalase activities in the myocardial mitochondria, and increased its Ca-45 uptake and Ca2+-ATPase activity. Thus, taurine antagonizes the oxidative stress injury in the myocardial mitochondria induced by the hyperhomocysteinemia.

语种: 英语
WOS记录号: WOS:000223266300005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54749
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: 1.Key Lab Cardiovasc Mol Biol Educ Minist, Beijing, Peoples R China
2.Peking Univ, Inst Cardiovasc Dis Res, Hosp 1, Beijing 100034, Peoples R China
3.Peking Univ, Dept Physiol & Pathophysiol, Beijing 100871, Peoples R China
4.Chinese Acad Sci, Inst Biophys, Beijing 100080, Peoples R China

Recommended Citation:
Chang, L,Xu, J,Yu, F,et al. Taurine protected myocardial mitochondria injury induced by hyperhomocysteinemia in rats[J]. AMINO ACIDS,2004,27(1):37-48.
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