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Disturbance of serum interleukin-2 and interleukin-8 levels in oosttraumatic and non-posttraumatic stress disorder earthquake survivors in northern China
Song, Yuqing1,2; Zhou, Dongfeng2; Guan, Zhenquan2; Wang, Xiangdong2
关键词Posttraumatic Stress Disorder Cytokine Interleukin
刊名NEUROIMMUNOMODULATION
2007
DOI10.1159/000112050
14期:5页:248-254
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism ; Immunology ; Neurosciences
研究领域[WOS]Endocrinology & Metabolism ; Immunology ; Neurosciences & Neurology
关键词[WOS]CORTICOTROPIN-RELEASING HORMONE ; NECROSIS-FACTOR-ALPHA ; IMMUNE-SYSTEM ; PSYCHOLOGICAL STRESS ; CELLULAR-IMMUNITY ; MAJOR DEPRESSION ; GENE-EXPRESSION ; CYTOKINES ; BRAIN ; PITUITARY
英文摘要

Objective: It is evident that immune cytokines are involved in the pathophysiology of posttraumatic stress disorder (PTSD), but results of different studies are still inconsistent. Here, serum interleukin (IL)-2, IL-6 and IL-8 levels were compared between earthquake survivors with PTSD, those with non-PTSD and normal controls to investigate whether there is any relationship between cytokine levels and PTSD. In addition, the relationship of these cytokines with psychological parameters of the disorder was examined as well. Methods: Thirty-four earthquake survivors with PTSD (according to DSM-IV criteria), 30 earthquake survivors with non-PTSD and 34 controls were recruited in northern China using the Composite International Diagnostic Interview instrument. Serum IL-2, IL-6 and IL-8 levels were compared. IL-2 levels were measured by radioimmunometric assay, while serum IL-6 and IL-8 levels were measured using sandwich enzyme-linked immunosorbent assay. Psychological symptoms were assessed using 3 subscales of the Symptoms Checklist (SCL-90-R), including depression, anxiety and somatization. Results: Only earthquake survivors diagnosed with PTSD had significantly lower serum IL-8 levels. Also, we found that earthquake survivors (either with PTSD or non-PTSD) had significantly lower serum IL-2 levels and more severe psychological symptoms. The severity of depressive and anxiety symptoms in earthquake survivors was positively related to serum IL-6 levels. Conclusions: PTSD may be associated with a reduced level of serum IL-8, and traumatic survivors may be associated with a lower level of serum IL-2. Copyright (c) 2007 S. Karger AG, Basel.

语种英语
WOS记录号WOS:000253014800006
引用统计
被引频次:32[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54751
专题北京大学精神卫生研究所
北京大学精神卫生研究所_精神科
作者单位1.Beijing Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
2.Univ Hong Kong, Fac Med, Dept Psychiat, Lab Block, Hong Kong, Hong Kong, Peoples R China
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GB/T 7714
Song, Yuqing,Zhou, Dongfeng,Guan, Zhenquan,et al. Disturbance of serum interleukin-2 and interleukin-8 levels in oosttraumatic and non-posttraumatic stress disorder earthquake survivors in northern China[J]. NEUROIMMUNOMODULATION,2007,14(5):248-254.
APA Song, Yuqing,Zhou, Dongfeng,Guan, Zhenquan,&Wang, Xiangdong.(2007).Disturbance of serum interleukin-2 and interleukin-8 levels in oosttraumatic and non-posttraumatic stress disorder earthquake survivors in northern China.NEUROIMMUNOMODULATION,14(5),248-254.
MLA Song, Yuqing,et al."Disturbance of serum interleukin-2 and interleukin-8 levels in oosttraumatic and non-posttraumatic stress disorder earthquake survivors in northern China".NEUROIMMUNOMODULATION 14.5(2007):248-254.
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