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学科主题: 基础医学
题名:
High-density lipoprotein of patients with type 2 diabetes mellitus elevates the capability of promoting migration and invasion of breast cancer cells
作者: Pan, Bing1,2; Ren, Hui1,2; Ma, Yijing1,2; Liu, Donghui1,2; Yu, Baoqi1,2; Ji, Liang1,2; Pan, Ling3; Li, Jing4; Yang, Liangui5; Lv, Xiaofeng5; Shen, Xiaoli3; Chen, Bin5; Zhang, Youyi1,2; Willard, Belinda6; He, Yubin5; Zheng, Lemin1,2
关键词: breast cancer ; type 2 diabetes mellitus ; HDL ; proliferation ; migration ; invasion
刊名: INTERNATIONAL JOURNAL OF CANCER
发表日期: 2012-07-01
DOI: 10.1002/ijc.26341
卷: 131, 期:1, 页:70-82
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: ENDOTHELIAL GROWTH-FACTOR ; MATRIX METALLOPROTEINASES ; CARDIOVASCULAR-DISEASE ; THERAPEUTIC TARGET ; MASS-SPECTROMETRY ; IN-VITRO ; CHOLESTEROL ; RISK ; PLASMA ; INFLAMMATION
英文摘要:

Epidemiological studies suggested complicated associations between type 2 diabetes mellitus and breast cancer. There is a significant inverse association between high-density lipoprotein (HDL) and the risk and mortality of breast cancer. However, HDL could be modified in various ways in diabetes patients, and this may lead to the altered effects on many different types of cells. In our study, we found that glycation and oxidation levels are significantly higher in HDL from type 2 diabetes mellitus patients compared to that from healthy subjects. Diabetic HDL dramatically had a stronger capability to promote cell proliferation, migration and invasion of breast cancer (as examined both on hormone-independent cells and on hormone-dependent cells). In addition, glycated and oxidized HDL, which were produced in vitro, acted in similar way as diabetic HDL. Diabetic HDL, glycated HDL and oxidized HDL also induced higher synthesis and secretion of VEGF-C, MMP-2 and MMP-9 from malondialdehyde (MDA)-MB-231 cells. It was indicated that diabetic, glycated and oxidized HDL promote MDA-MB-231 cell migration and invasion through ERK and p38 MAPK pathways, and Akt pathway plays an important role as well in MDA-MB-231 cell invasion. The Akt, ERK and p38 MAPK pathways are also involved in VEGF-C and MMP-9 secretion induced by diabetic, glycated and oxidized HDL. Our study demonstrated that glycation and oxidation of HDL in diabetic patients could lead to abnormal actions on MDA-MB-231 cell proliferation, migration and invasion, thereby promoting the progression of breast cancer. This will largely draw the attention of HDL-based treatments in diabetic patients especially those with breast cancer.

语种: 英语
所属项目编号: 30900595 ; 30821001 ; 7102104 ; 2010CB912504 ; 2011CB503900 ; 2009J01112 ; 70103-007 ; 20090001120039 ; 20100001120034
项目资助者: National Natural Science Foundation of China ; Natural Science Foundation of Beijing ; "973" National ST Major Project ; Natural Science Foundation of Fujian ; Peking University Health Science Center ; "The Returned Overseas Chinese Scholars", "New Century Excellent Talents in Universities", State Education Ministry of China
WOS记录号: WOS:000303050100008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54761
Appears in Collections:基础医学院_心血管所_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Inst Cardiovasc Sci, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Key Lab Mol Cardiovasc Sci, Minist Educ, Beijing 100191, Peoples R China
3.Fujian Prov Hosp, Fujian Key Lab Cardiovasc Dis, Fuzhou, Peoples R China
4.Mil Gen Hosp Beijing, Beijing, Peoples R China
5.Cleveland Clin, Prote Lab, Cleveland, OH 44106 USA
6.China Japan Friendship Hosp, Dept Cardiovasc Med, Beijing, Peoples R China

Recommended Citation:
Pan, Bing,Ren, Hui,Ma, Yijing,et al. High-density lipoprotein of patients with type 2 diabetes mellitus elevates the capability of promoting migration and invasion of breast cancer cells[J]. INTERNATIONAL JOURNAL OF CANCER,2012,131(1):70-82.
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