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学科主题基础医学
High-density lipoprotein of patients with type 2 diabetes mellitus elevates the capability of promoting migration and invasion of breast cancer cells
Pan, Bing1,2; Ren, Hui1,2; Ma, Yijing1,2; Liu, Donghui1,2; Yu, Baoqi1,2; Ji, Liang1,2; Pan, Ling3; Li, Jing4; Yang, Liangui5; Lv, Xiaofeng5; Shen, Xiaoli3; Chen, Bin5; Zhang, Youyi1,2; Willard, Belinda6; He, Yubin5; Zheng, Lemin1,2
关键词Breast Cancer Type 2 Diabetes Mellitus Hdl Proliferation Migration Invasion
刊名INTERNATIONAL JOURNAL OF CANCER
2012-07-01
DOI10.1002/ijc.26341
131期:1页:70-82
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]ENDOTHELIAL GROWTH-FACTOR ; MATRIX METALLOPROTEINASES ; CARDIOVASCULAR-DISEASE ; THERAPEUTIC TARGET ; MASS-SPECTROMETRY ; IN-VITRO ; CHOLESTEROL ; RISK ; PLASMA ; INFLAMMATION
英文摘要

Epidemiological studies suggested complicated associations between type 2 diabetes mellitus and breast cancer. There is a significant inverse association between high-density lipoprotein (HDL) and the risk and mortality of breast cancer. However, HDL could be modified in various ways in diabetes patients, and this may lead to the altered effects on many different types of cells. In our study, we found that glycation and oxidation levels are significantly higher in HDL from type 2 diabetes mellitus patients compared to that from healthy subjects. Diabetic HDL dramatically had a stronger capability to promote cell proliferation, migration and invasion of breast cancer (as examined both on hormone-independent cells and on hormone-dependent cells). In addition, glycated and oxidized HDL, which were produced in vitro, acted in similar way as diabetic HDL. Diabetic HDL, glycated HDL and oxidized HDL also induced higher synthesis and secretion of VEGF-C, MMP-2 and MMP-9 from malondialdehyde (MDA)-MB-231 cells. It was indicated that diabetic, glycated and oxidized HDL promote MDA-MB-231 cell migration and invasion through ERK and p38 MAPK pathways, and Akt pathway plays an important role as well in MDA-MB-231 cell invasion. The Akt, ERK and p38 MAPK pathways are also involved in VEGF-C and MMP-9 secretion induced by diabetic, glycated and oxidized HDL. Our study demonstrated that glycation and oxidation of HDL in diabetic patients could lead to abnormal actions on MDA-MB-231 cell proliferation, migration and invasion, thereby promoting the progression of breast cancer. This will largely draw the attention of HDL-based treatments in diabetic patients especially those with breast cancer.

语种英语
WOS记录号WOS:000303050100008
项目编号30900595 ; 30821001 ; 7102104 ; 2010CB912504 ; 2011CB503900 ; 2009J01112 ; 70103-007 ; 20090001120039 ; 20100001120034
资助机构National Natural Science Foundation of China ; Natural Science Foundation of Beijing ; "973" National ST Major Project ; Natural Science Foundation of Fujian ; Peking University Health Science Center ; "The Returned Overseas Chinese Scholars", "New Century Excellent Talents in Universities", State Education Ministry of China
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54761
专题北京大学基础医学院_心血管所
北京大学基础医学院
作者单位1.Peking Univ, Hlth Sci Ctr, Inst Cardiovasc Sci, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Key Lab Mol Cardiovasc Sci, Minist Educ, Beijing 100191, Peoples R China
3.Fujian Prov Hosp, Fujian Key Lab Cardiovasc Dis, Fuzhou, Peoples R China
4.Mil Gen Hosp Beijing, Beijing, Peoples R China
5.Cleveland Clin, Prote Lab, Cleveland, OH 44106 USA
6.China Japan Friendship Hosp, Dept Cardiovasc Med, Beijing, Peoples R China
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GB/T 7714
Pan, Bing,Ren, Hui,Ma, Yijing,et al. High-density lipoprotein of patients with type 2 diabetes mellitus elevates the capability of promoting migration and invasion of breast cancer cells[J]. INTERNATIONAL JOURNAL OF CANCER,2012,131(1):70-82.
APA Pan, Bing.,Ren, Hui.,Ma, Yijing.,Liu, Donghui.,Yu, Baoqi.,...&Zheng, Lemin.(2012).High-density lipoprotein of patients with type 2 diabetes mellitus elevates the capability of promoting migration and invasion of breast cancer cells.INTERNATIONAL JOURNAL OF CANCER,131(1),70-82.
MLA Pan, Bing,et al."High-density lipoprotein of patients with type 2 diabetes mellitus elevates the capability of promoting migration and invasion of breast cancer cells".INTERNATIONAL JOURNAL OF CANCER 131.1(2012):70-82.
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