IR@PKUHSC  > 北京大学药学院  > 药剂学系
学科主题药学
Freeze-drying and in vitro release kinetics of poly(ethylene glycol)Poly(dl-lactide) block copolymer micelles
Yang Zhuo-Li; Li Xin-Ru; Yang Ke-Wei; Liu Yan
关键词Poly(Ethylene Glycol)-Poly(Dl-lactide) Polymeric Micelle Amphotericin b Lyophilization In Vitro Release
刊名ACTA CHIMICA SINICA
2007-10-14
65期:19页:2169-2174
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]POLYMERIC MICELLES ; DELIVERY-SYSTEMS ; AMPHOTERICIN-B ; DRUG-DELIVERY ; CARRIERS ; SOLUBILIZATION
英文摘要

A series of poly(ethylene glycol)-poly(dl-lactide) (PEG-PLA) block copolymers with varying molecular weights were synthesized. Drug-loaded micelles were prepared using amphotericin B (AmB) as the model drug. The PEG-PLA copolymers were freeze-dried to obtain long-term stable formulations. Saccharides at various concentrations including mannose, trehalose and glucose, Pluronic F68 and PEG were used as lyoprotectants, respectively. The protective effects of the various types of lyoprotectants on the particle size and size distribution during freeze-drying process and redispersion were investigated. The results indicated that the saccharides, Pluronic F68 and PEG all could stabilize the micellar particles in the lyophilization when the weight ratio of PLA block was smaller than that of PEG block. While the weight ratio of PLA block was bigger than that of PEG block, only steric stabilizers such as PEG and F68 were able to protect PEG-PLA micelles from the agglomeration in the freeze-drying procedure. The sustained in vitro release of AmB from PEG-PLA micelles was evidenced. The in vitro release behavior could be best described by the first order equation.

语种中文
WOS记录号WOS:000250308600015
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54765
Collection北京大学药学院_药剂学系
作者单位Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Yang Zhuo-Li,Li Xin-Ru,Yang Ke-Wei,et al. Freeze-drying and in vitro release kinetics of poly(ethylene glycol)Poly(dl-lactide) block copolymer micelles[J]. ACTA CHIMICA SINICA,2007,65(19):2169-2174.
APA Yang Zhuo-Li,Li Xin-Ru,Yang Ke-Wei,&Liu Yan.(2007).Freeze-drying and in vitro release kinetics of poly(ethylene glycol)Poly(dl-lactide) block copolymer micelles.ACTA CHIMICA SINICA,65(19),2169-2174.
MLA Yang Zhuo-Li,et al."Freeze-drying and in vitro release kinetics of poly(ethylene glycol)Poly(dl-lactide) block copolymer micelles".ACTA CHIMICA SINICA 65.19(2007):2169-2174.
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