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学科主题: 药学
题名:
Freeze-drying and in vitro release kinetics of poly(ethylene glycol)Poly(dl-lactide) block copolymer micelles
作者: Yang Zhuo-Li; Li Xin-Ru; Yang Ke-Wei; Liu Yan
关键词: poly(ethylene glycol)-poly(dl-lactide) ; polymeric micelle ; amphotericin B ; lyophilization ; in vitro release
刊名: ACTA CHIMICA SINICA
发表日期: 2007-10-14
卷: 65, 期:19, 页:2169-2174
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: POLYMERIC MICELLES ; DELIVERY-SYSTEMS ; AMPHOTERICIN-B ; DRUG-DELIVERY ; CARRIERS ; SOLUBILIZATION
英文摘要:

A series of poly(ethylene glycol)-poly(dl-lactide) (PEG-PLA) block copolymers with varying molecular weights were synthesized. Drug-loaded micelles were prepared using amphotericin B (AmB) as the model drug. The PEG-PLA copolymers were freeze-dried to obtain long-term stable formulations. Saccharides at various concentrations including mannose, trehalose and glucose, Pluronic F68 and PEG were used as lyoprotectants, respectively. The protective effects of the various types of lyoprotectants on the particle size and size distribution during freeze-drying process and redispersion were investigated. The results indicated that the saccharides, Pluronic F68 and PEG all could stabilize the micellar particles in the lyophilization when the weight ratio of PLA block was smaller than that of PEG block. While the weight ratio of PLA block was bigger than that of PEG block, only steric stabilizers such as PEG and F68 were able to protect PEG-PLA micelles from the agglomeration in the freeze-drying procedure. The sustained in vitro release of AmB from PEG-PLA micelles was evidenced. The in vitro release behavior could be best described by the first order equation.

语种: 中文
WOS记录号: WOS:000250308600015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54765
Appears in Collections:北京大学药学院_药剂学系_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100083, Peoples R China

Recommended Citation:
Yang Zhuo-Li,Li Xin-Ru,Yang Ke-Wei,et al. Freeze-drying and in vitro release kinetics of poly(ethylene glycol)Poly(dl-lactide) block copolymer micelles[J]. ACTA CHIMICA SINICA,2007,65(19):2169-2174.
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