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学科主题: 基础医学
题名:
Autophagy eliminates cytoplasmic beta-catenin and NICD to promote the cardiac differentiation of P19CL6 cells
作者: Jia, Zhuqing; Wang, Jiaji; Wang, Weiping; Tian, Yuyao; XiangWei, Wenshu; Chen, Ping; Ma, Kangtao; Zhou, Chunyan
关键词: Autophagy ; Atg7 ; Atg5 ; Wnt ; Notch ; Cardiomyocyte differentiation
刊名: CELLULAR SIGNALLING
发表日期: 2014-11-01
DOI: 10.1016/j.cellsig.2014.07.028
卷: 26, 期:11, 页:2299-2305
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology
研究领域[WOS]: Cell Biology
关键词[WOS]: EMBRYONIC STEM-CELLS ; CARDIOMYOCYTE DIFFERENTIATION ; WNT/BETA-CATENIN ; DOWN-REGULATION ; PATHWAY ; CARDIOMYOGENESIS ; LOCALIZATION ; DEGRADATION ; INHIBITION ; INDUCTION
英文摘要:

Autophagy plays important roles in adipogenesis and neuron development. However, how autophagy contributes to cardiac development is not well understood. The main aim of our study was to determine the association between autophagy and myocardial differentiation and its roles in this process. Using a well-established in vitro cardiomyocyte differentiation system, P19CL6 cells, we found that autophagy occurred from the early stage of cardiac differentiation. Blocking autophagy by knocking-down of autophagy-related gene Atg7 or Atg5 inhibited the cardiac differentiation of P19CL6 cells. Further investigation demonstrated that LO and P62 could form a complex with S-catenin and NICD, respectively, and promoted the degradation of beta-catenin and NICD. Enhancing autophagy promoted the formation of complex, whereas blocking autophagy attenuated the degradation of beta-catenin and NICD. Taken together, autophagy could facilitate P19CL6 cells to complete the cardiac differentiation process through blocking Wnt and Notch signaling pathways. (C) 2014 The Authors. Published by Elsevier Inc.

语种: 英语
所属项目编号: 81371889 ; 81370236 ; 81070112 ; 81071675 ; 81170713 ; 5122021 ; B07001 ; BMU20120315 ; BMU20120315
项目资助者: National Natural Science Foundation of China ; Natural Science Foundation of Beijing, China ; Leading Academic Discipline Project of Beijing Education Bureau ; 111 Project of China ; PUHSC ; National Taiwan University
WOS记录号: WOS:000342717400001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54766
Appears in Collections:基础医学院_心血管所_期刊论文

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作者单位: Peking Univ, Dept Biochem & Mol Biol, Key Lab Mol Cardiovasc Sci, Sch Basic Med Sci,Minist Educ China, Beijing 100191, Peoples R China

Recommended Citation:
Jia, Zhuqing,Wang, Jiaji,Wang, Weiping,et al. Autophagy eliminates cytoplasmic beta-catenin and NICD to promote the cardiac differentiation of P19CL6 cells[J]. CELLULAR SIGNALLING,2014,26(11):2299-2305.
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