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学科主题: 药学
题名:
Synthesis of 5 ′-O-(2-azido-2-deoxy-alpha-D-glycosyl)nucleosides and their antitumor activities
作者: Zhang, GS; Chen, J; Min, AM; Zhang, LH
刊名: HELVETICA CHIMICA ACTA
发表日期: 2003
卷: 86, 期:6, 页:2073-2081
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: PENICILLIUM-BREVICOMPACTUM ; POTENT AGONISTS ; ADENOPHOSTIN-A ; GROWTH ; NUCLEOSIDES ; ASSAY ; PART
英文摘要:

The 1,3,4,6-tetra-O-acetyl-2-azido-2-deoxy-beta-D-mannopyranose (4) or the mixture of 1,3,6-tri-O-acetyl-2-azido-2-deoxy-4-O-(2,3,4,6-tetra-O-acetyl-beta-D-galactopyranosyl)-beta-D-mannopyranose (10) and the corresponding alpha-D-glucopyranose-type glycosyl donor 9/10 reacted at room temperature with protected nucleosides 12-15 in CH2Cl2 solution in the presence of BF3 . OEt2 as promoter to give 5′-O-(2-azido-2-deoxy-alpha-D-glycosyl)nucleosides in reasonable yields (Schemes 2 and 3). Only the 5′-O-(alpha-D-mannopyranosyl)nucleosides were obtained. Compounds 21,28,30, and 31 showed growth inhibition of HeLa cells and hepatoma Bel-7402 cells at a concentration of 10 mum in vitro.

语种: 英语
WOS记录号: WOS:000184248000017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54767
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, Natl Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

Recommended Citation:
Zhang, GS,Chen, J,Min, AM,et al. Synthesis of 5 ′-O-(2-azido-2-deoxy-alpha-D-glycosyl)nucleosides and their antitumor activities[J]. HELVETICA CHIMICA ACTA,2003,86(6):2073-2081.
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