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学科主题: 公共卫生
题名:
Oral Zinc Supplementation for the Treatment of Acute Diarrhea in Children: A Systematic Review and Meta-Analysis
作者: Lamberti, Laura M.1; Walker, Christa L. Fischer1; Chan, Kit Y.2,3; Jian, Wei-Yan2; Black, Robert E.1
关键词: zinc ; children ; global health ; China
刊名: NUTRIENTS
发表日期: 2013-11-01
DOI: 10.3390/nu5114715
卷: 5, 期:11, 页:4715-4740
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Nutrition & Dietetics
研究领域[WOS]: Nutrition & Dietetics
关键词[WOS]: PLACEBO-CONTROLLED TRIAL ; BANGLADESHI CHILDREN ; YOUNG-CHILDREN ; DOUBLE-BLIND ; VITAMIN-A ; EFFICACY ; INFANTS ; MORBIDITY ; IMPACT ; INDIA
英文摘要:

Evidence supporting the impact of therapeutic zinc supplementation on the duration and severity of diarrhea among children under five is largely derived from studies conducted in South Asia. China experiences a substantial portion of the global burden of diarrhea, but the impact of zinc treatment among children under five has not been well documented by previously published systematic reviews on the topic. We therefore conducted a systematic literature review, which included an exhaustive search of the Chinese literature, in an effort to update previously published estimates of the effect of therapeutic zinc. We conducted systematic literature searches in various databases, including the China National Knowledge Infrastructure (CNKI), and abstracted relevant data from studies meeting our inclusion and exclusion criteria. We used STATA 12.0 to pool select outcomes and to generate estimates of percentage difference and relative risk comparing outcomes between zinc and control groups. We identified 89 Chinese and 15 non-Chinese studies for the review, including studies in 10 countries from all WHO geographic regions, and analyzed a total of 18,822 diarrhea cases (9469 zinc and 9353 control). None of the included Chinese studies had previously been included in published pooled effect estimates. Chinese and non-Chinese studies reported the effect of therapeutic zinc supplementation on decreased episode duration, stool output, stool frequency, hospitalization duration and proportion of episodes lasting beyond three and seven days. Pooling Chinese and non-Chinese studies yielded an overall 26% (95% CI: 20%-32%) reduction in the estimated relative risk of diarrhea lasting beyond three days among zinc-treated children. Studies conducted in and outside China report reductions in morbidity as a result of oral therapeutic zinc supplementation for acute diarrhea among children under five years of age. The WHO recommendation for zinc treatment of diarrhea episodes should be supported in all low- and middle-income countries.

语种: 英语
项目资助者: Bill and Melinda Gates Foundation
WOS记录号: WOS:000328628600029
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54768
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD 21205 USA
2.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Hlth Policy & Management, Beijing 10083, Peoples R China
3.Univ Edinburgh, Ctr Populat Hlth Sci, Sch Med, Edinburgh EH8 9AG, Midlothian, Scotland

Recommended Citation:
Lamberti, Laura M.,Walker, Christa L. Fischer,Chan, Kit Y.,et al. Oral Zinc Supplementation for the Treatment of Acute Diarrhea in Children: A Systematic Review and Meta-Analysis[J]. NUTRIENTS,2013,5(11):4715-4740.
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