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学科主题: 公共卫生
题名:
Effect of scheduled monitoring of liver function during anti-Tuberculosis treatment in a retrospective cohort in China
作者: Wu, Shanshan1; Xia, Yinyin2; Lv, Xiaozhen1; Zhang, Yuan1; Tang, Shaowen1; Yang, Zhirong1; Tu, Dehua3; Deng, Peiyuan4; Cheng, Shiming2; Wang, Xiaomeng5; Yuan, Yanli6; Liu, Feiying7; Hu, Daiyu8; Zhan, Siyan1
关键词: Tuberculosis ; Hepatotoxicity ; Monitoring
刊名: BMC PUBLIC HEALTH
发表日期: 2012-06-19
DOI: 10.1186/1471-2458-12-454
卷: 12
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Public, Environmental & Occupational Health
研究领域[WOS]: Public, Environmental & Occupational Health
关键词[WOS]: PROPENSITY SCORE METHODS ; DRUG-INDUCED HEPATOTOXICITY ; TUBERCULOSIS ; MANAGEMENT ; REGRESSION ; THERAPY ; MODELS
英文摘要:

Background: Data on effect of regular liver function monitoring during anti-TB treatment is limited in China. This study aimed to evaluate the effects of scheduled liver function monitoring on identification of asymptomatic liver damage and anti-TB treatment outcomes during anti-TB treatment.

Methods: A retrospective analysis was performed based on a national-level cohort study. A total of 273 patients developing liver dysfunction were divided into two groups, 111 patients who were diagnosed through scheduled liver function test within two months after initiation of anti-TB treatment formed scheduled monitoring group, others who were diagnosed due to developing symptoms formed passive detection group (n = 162). The two groups were compared through clinical features, prognosis of liver dysfunction and impact on anti-TB treatment using propensity score weighting analysis.

Results: 33.3% of 273 patients did not have any clinical symptoms, including 8 with severe hepatotoxicity. 1.8% in scheduled monitoring group and 11.1% in passive detection group required hospitalization (P = 0.004). Regarding the prognosis of liver dysfunction, most patients recovered, no death happened in scheduled monitoring group while 3 died in passive detection group. In terms of impact on anti-TB treatment, 35.1% in scheduled monitoring group and 56.8% in passive detection group changed their anti-TB treatment (P = 0.001).

Conclusions: Scheduled monitoring is effective in identifying asymptomatic liver damage, reducing hospitalization rate and improving compliance of anti-TB treatment.

语种: 英语
所属项目编号: TB07-030 ; 81072387 ; 7111006
项目资助者: China Program for the Global Fund to Fight TB ; National Natural Science Foundation of China ; Beijing Natural Science Foundation
WOS记录号: WOS:000308923600001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54778
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Ctr Dis Control & Prevent Jilin Prov, Changchun, Peoples R China
2.Beijing Inst TB Control, Beijing, Peoples R China
3.State Food & Drug Adm, Ctr Drug Reassessment, Beijing, Peoples R China
4.Peking Univ, Dept Epidemiol & Biostat, Sch Publ Hlth, Hlth Sci Ctr, Beijing 100191, Peoples R China
5.Chinese Ctr Dis Control & Prevent, Ctr TB Control & Prevent, Beijing, Peoples R China
6.Ctr Dis Control & Prevent Zhejiang Prov, Hangzhou, Zhejiang, Peoples R China
7.Ctr Dis Control & Prevent Guangxi Zhuang Autonomo, Nanning, Peoples R China
8.Ctr Dis Control & Prevent Chongqing Municipal, Chongqing, Peoples R China

Recommended Citation:
Wu, Shanshan,Xia, Yinyin,Lv, Xiaozhen,et al. Effect of scheduled monitoring of liver function during anti-Tuberculosis treatment in a retrospective cohort in China[J]. BMC PUBLIC HEALTH,2012,12.
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