|Effect of scheduled monitoring of liver function during anti-Tuberculosis treatment in a retrospective cohort in China|
|Wu, Shanshan1; Xia, Yinyin2; Lv, Xiaozhen1; Zhang, Yuan1; Tang, Shaowen1; Yang, Zhirong1; Tu, Dehua3; Deng, Peiyuan4; Cheng, Shiming2; Wang, Xiaomeng5; Yuan, Yanli6; Liu, Feiying7; Hu, Daiyu8; Zhan, Siyan1|
|关键词||Tuberculosis Hepatotoxicity Monitoring|
|刊名||BMC PUBLIC HEALTH|
|WOS标题词||Science & Technology|
|类目[WOS]||Public, Environmental & Occupational Health|
|研究领域[WOS]||Public, Environmental & Occupational Health|
|关键词[WOS]||PROPENSITY SCORE METHODS ; DRUG-INDUCED HEPATOTOXICITY ; TUBERCULOSIS ; MANAGEMENT ; REGRESSION ; THERAPY ; MODELS|
Background: Data on effect of regular liver function monitoring during anti-TB treatment is limited in China. This study aimed to evaluate the effects of scheduled liver function monitoring on identification of asymptomatic liver damage and anti-TB treatment outcomes during anti-TB treatment.
Methods: A retrospective analysis was performed based on a national-level cohort study. A total of 273 patients developing liver dysfunction were divided into two groups, 111 patients who were diagnosed through scheduled liver function test within two months after initiation of anti-TB treatment formed scheduled monitoring group, others who were diagnosed due to developing symptoms formed passive detection group (n = 162). The two groups were compared through clinical features, prognosis of liver dysfunction and impact on anti-TB treatment using propensity score weighting analysis.
Results: 33.3% of 273 patients did not have any clinical symptoms, including 8 with severe hepatotoxicity. 1.8% in scheduled monitoring group and 11.1% in passive detection group required hospitalization (P = 0.004). Regarding the prognosis of liver dysfunction, most patients recovered, no death happened in scheduled monitoring group while 3 died in passive detection group. In terms of impact on anti-TB treatment, 35.1% in scheduled monitoring group and 56.8% in passive detection group changed their anti-TB treatment (P = 0.001).
Conclusions: Scheduled monitoring is effective in identifying asymptomatic liver damage, reducing hospitalization rate and improving compliance of anti-TB treatment.
|项目编号||TB07-030 ; 81072387 ; 7111006|
|资助机构||China Program for the Global Fund to Fight TB ; National Natural Science Foundation of China ; Beijing Natural Science Foundation|
|作者单位||1.Ctr Dis Control & Prevent Jilin Prov, Changchun, Peoples R China|
2.Beijing Inst TB Control, Beijing, Peoples R China
3.State Food & Drug Adm, Ctr Drug Reassessment, Beijing, Peoples R China
4.Peking Univ, Dept Epidemiol & Biostat, Sch Publ Hlth, Hlth Sci Ctr, Beijing 100191, Peoples R China
5.Chinese Ctr Dis Control & Prevent, Ctr TB Control & Prevent, Beijing, Peoples R China
6.Ctr Dis Control & Prevent Zhejiang Prov, Hangzhou, Zhejiang, Peoples R China
7.Ctr Dis Control & Prevent Guangxi Zhuang Autonomo, Nanning, Peoples R China
8.Ctr Dis Control & Prevent Chongqing Municipal, Chongqing, Peoples R China
|Wu, Shanshan,Xia, Yinyin,Lv, Xiaozhen,et al. Effect of scheduled monitoring of liver function during anti-Tuberculosis treatment in a retrospective cohort in China[J]. BMC PUBLIC HEALTH,2012,12.|
|APA||Wu, Shanshan.,Xia, Yinyin.,Lv, Xiaozhen.,Zhang, Yuan.,Tang, Shaowen.,...&Zhan, Siyan.(2012).Effect of scheduled monitoring of liver function during anti-Tuberculosis treatment in a retrospective cohort in China.BMC PUBLIC HEALTH,12.|
|MLA||Wu, Shanshan,et al."Effect of scheduled monitoring of liver function during anti-Tuberculosis treatment in a retrospective cohort in China".BMC PUBLIC HEALTH 12(2012).|