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Diverse vascular lesions in systemic lupus erythematosus and clinical implications
Tan, Ying1,2,3,4; Yu, Feng1,2,3,4; Liu, Gang1,2,3,4
关键词Atherosclerosis Systemic Lupus Erythematosus Endothelial Cells Thrombosis Vascular Lesions
刊名CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
2014-05-01
DOI10.1097/01.mnh.0000444812.65002.cb
23期:3页:218-223
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology ; Peripheral Vascular Disease
研究领域[WOS]Urology & Nephrology ; Cardiovascular System & Cardiology
关键词[WOS]ANTIPHOSPHOLIPID ANTIBODIES ; GLOMERULAR MICROTHROMBOSIS ; IMMUNE-COMPLEXES ; I ANTIBODIES ; 2 PARTS ; NEPHRITIS ; ATHEROSCLEROSIS ; COMPLEMENT ; DISEASE ; GLOMERULONEPHRITIS
英文摘要

Purpose of review

Vascular injury is one of the typical symptoms of systemic lupus erythematosus (SLE), and may play a key role in the choice of treatment strategy and prediction of prognosis. In this review, diverse vascular lesions in SLE and their clinical significance are discussed.

Recent findings

The clinical features of vascular disease in SLE differ from organ to organ, and may be extreme with regard to renal vascular lesions. Vascular lesions in SLE may be of inflammatory or thrombotic origin, and immune system dysfunction is considered to be a predominant feature. Numerous lines of evidence suggest that the activation and injury of endothelial cells might play a key role in the pathogenesis.

Vascular lesions in SLE are mediated by a complex interaction between the immune system and other contributing factors. Different therapies developed for vascular lesions, both immunosuppressive and nonimmunosuppressive, should be selected based on the different clinical and pathological characteristics, and our future understanding of the different mechanisms involved.

语种英语
WOS记录号WOS:000334502900005
项目编号2012CB517700 ; 81100497
资助机构Chinese 973 project ; National Natural Science Foundation of China
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54783
专题北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
2.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
3.Peking Univ, Hosp 1, Dept Med, Div Renal, Beijing 100034, Peoples R China
4.Minist Educ, Key Lab Chron Kidney Dis Prevent & Treatment, Beijing, Peoples R China
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GB/T 7714
Tan, Ying,Yu, Feng,Liu, Gang. Diverse vascular lesions in systemic lupus erythematosus and clinical implications[J]. CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION,2014,23(3):218-223.
APA Tan, Ying,Yu, Feng,&Liu, Gang.(2014).Diverse vascular lesions in systemic lupus erythematosus and clinical implications.CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION,23(3),218-223.
MLA Tan, Ying,et al."Diverse vascular lesions in systemic lupus erythematosus and clinical implications".CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION 23.3(2014):218-223.
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