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CuBr-NCS-Mediated Multicomponent Azide-Alkyne Cycloaddition: Mild and Efficient Synthesis of 5-Bromo-1,4-Disubstituted-1,2,3-Triazoles
Li, Lingjun1; Li, Ran1; Zhu, Anlian1; Zhang, Guisheng1; Zhang, Lihe2
关键词Multicomponent Azide-alkyne Cycloaddition Click Chemistry 5-bromo-1 Copper Catalysis 4-disubstituted-1 2 3-triazole
刊名SYNLETT
2011-04-01
DOI10.1055/s-0030-1259908
6页:874-878
收录类别SCI ; IC ; CCR
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]CLICK CHEMISTRY ; ROUTE ; 1,2,3-TRIAZOLES ; DERIVATIVES ; NUCLEOSIDE ; MIMICS
英文摘要

CuBr-NCS was found to be a mild and efficient reaction system to promote the multicomponent azide-alkyne cycloaddition reactions. Under the reaction conditions, terminal alkynes and azides can react smoothly at ambient temperature to give the target products 5-bromo-1,4-disubsituted-1,2,3-triazoles in moderate to good yields with a wide tolerance of other sensitive functional groups. The further successful application of the CuBr-NCS reaction system in sugar and cyclic adenosine 5′-diphosphoribose (cADPR) analogues illustrated the value of this method in the synthesis of designed biomolecules.

语种英语
WOS记录号WOS:000289122000025
项目编号20802017 ; 084100510002
资助机构National Natural Sciences Foundation of China ; Innovation Scientists and Technicians Troop Construction Projects of Henan Province
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54795
专题北京大学药学院
北京大学药学院_药物化学系
作者单位1.Henan Normal Univ, Coll Chem & Environm Sci, Key Lab Green Chem Media & React, Minist Educ, Xinxiang 453007, Peoples R China
2.Peking Univ, Natl Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Li, Lingjun,Li, Ran,Zhu, Anlian,et al. CuBr-NCS-Mediated Multicomponent Azide-Alkyne Cycloaddition: Mild and Efficient Synthesis of 5-Bromo-1,4-Disubstituted-1,2,3-Triazoles[J]. SYNLETT,2011(6):874-878.
APA Li, Lingjun,Li, Ran,Zhu, Anlian,Zhang, Guisheng,&Zhang, Lihe.(2011).CuBr-NCS-Mediated Multicomponent Azide-Alkyne Cycloaddition: Mild and Efficient Synthesis of 5-Bromo-1,4-Disubstituted-1,2,3-Triazoles.SYNLETT(6),874-878.
MLA Li, Lingjun,et al."CuBr-NCS-Mediated Multicomponent Azide-Alkyne Cycloaddition: Mild and Efficient Synthesis of 5-Bromo-1,4-Disubstituted-1,2,3-Triazoles".SYNLETT .6(2011):874-878.
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