IR@PKUHSC  > 北京大学精神卫生研究所
学科主题精神卫生
Functional MRI in attention-deficit hyperactivity disorder: Evidence for hypofrontality
Zang, YF; Jin, Z; Weng, XC; Zhang, L; Zeng, YW; Yang, L; Wang, YF; Seidman, LJ; Faraone, SV
关键词Attention-deficit Hyperactivity Disorder Functional Magnetic Resonance Imaging Stroop Effect Hypofrontality Methylphenidate Compensation
刊名BRAIN & DEVELOPMENT
2005-12-01
DOI10.1016/j.braindev.2004.11.009
27期:8页:544-550
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]BASAL GANGLIA VOLUMES ; MAGNETIC-RESONANCE ; DEFICIT/HYPERACTIVITY DISORDER ; CEREBELLAR ; CHILDREN ; METHYLPHENIDATE ; ADHD ; SCHIZOPHRENIA ; RELAXOMETRY ; ADOLESCENTS
英文摘要

Using event-related functional magnetic resonance imaging to study the Stroop, effect on both behavioral and brain activation of ADHD children off or on methylphenidate (MPH). Nine ADHD boys (aged 9.8-14.5 years) and 9 age-matched normal controls were included. A Stroop-like paradigm was used. AFNI (Analysis of Functional Neurolmaging) and its Deconvolution Analysis were used in a descriptive comparison between ADHD and control groups. (1) Both behavioral reaction time and brain activation showed Stroop effect in controls but neither was found in ADHD children off MPH. When MPH was administered, the Stroop effect tended to appear. (2) The activation volume (AV) of prefrontal cortex (PFC) in both the neutral (NC) and interference conditions (IQ in ADHD children off MPH was smaller than in controls. AV of anterior cingulate cortex in the IC in ADHD children off MPH was smaller than that in controls, but was similar in the NC to that in controls. AV of the basal ganglia, insula and cerebellum was also smaller in the IC, but was larger in the NC for ADHD children off MPH compared with controls. These findings are consistent with prior findings of hypofrontality in ADHD children and implicate a compensatory network including basal ganglia, insula and cerebellum for relative lower cognitive load tasks. (c) 2005 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000234199200002
引用统计
被引频次:103[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54797
专题北京大学精神卫生研究所
作者单位1.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
2.306 Hosp, Dept MRI, Beijing 100101, Peoples R China
3.Massachusetts Mental Hlth Ctr, Boston, MA 02115 USA
4.Harvard Univ, Sch Med, Dept Psychiat, Cambridge, MA 02138 USA
5.Massachusetts Gen Hosp, Psychiat Serv, Boston, MA 02114 USA
6.Chinese Acad Sci, Inst Psychol, Lab Higher Brain Funct, Beijing 100101, Peoples R China
7.Harvard Univ, Inst Psychiat Epidemiol & Genet, Boston, MA 02115 USA
8.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100864, Peoples R China
推荐引用方式
GB/T 7714
Zang, YF,Jin, Z,Weng, XC,et al. Functional MRI in attention-deficit hyperactivity disorder: Evidence for hypofrontality[J]. BRAIN & DEVELOPMENT,2005,27(8):544-550.
APA Zang, YF.,Jin, Z.,Weng, XC.,Zhang, L.,Zeng, YW.,...&Faraone, SV.(2005).Functional MRI in attention-deficit hyperactivity disorder: Evidence for hypofrontality.BRAIN & DEVELOPMENT,27(8),544-550.
MLA Zang, YF,et al."Functional MRI in attention-deficit hyperactivity disorder: Evidence for hypofrontality".BRAIN & DEVELOPMENT 27.8(2005):544-550.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zang, YF]的文章
[Jin, Z]的文章
[Weng, XC]的文章
百度学术
百度学术中相似的文章
[Zang, YF]的文章
[Jin, Z]的文章
[Weng, XC]的文章
必应学术
必应学术中相似的文章
[Zang, YF]的文章
[Jin, Z]的文章
[Weng, XC]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。