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学科主题: 精神卫生
题名:
Functional MRI in attention-deficit hyperactivity disorder: Evidence for hypofrontality
作者: Zang, YF; Jin, Z; Weng, XC; Zhang, L; Zeng, YW; Yang, L; Wang, YF; Seidman, LJ; Faraone, SV
关键词: attention-deficit hyperactivity disorder ; functional magnetic resonance imaging ; Stroop effect ; hypofrontality ; methylphenidate ; compensation
刊名: BRAIN & DEVELOPMENT
发表日期: 2005-12-01
DOI: 10.1016/j.braindev.2004.11.009
卷: 27, 期:8, 页:544-550
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: BASAL GANGLIA VOLUMES ; MAGNETIC-RESONANCE ; DEFICIT/HYPERACTIVITY DISORDER ; CEREBELLAR ; CHILDREN ; METHYLPHENIDATE ; ADHD ; SCHIZOPHRENIA ; RELAXOMETRY ; ADOLESCENTS
英文摘要:

Using event-related functional magnetic resonance imaging to study the Stroop, effect on both behavioral and brain activation of ADHD children off or on methylphenidate (MPH). Nine ADHD boys (aged 9.8-14.5 years) and 9 age-matched normal controls were included. A Stroop-like paradigm was used. AFNI (Analysis of Functional Neurolmaging) and its Deconvolution Analysis were used in a descriptive comparison between ADHD and control groups. (1) Both behavioral reaction time and brain activation showed Stroop effect in controls but neither was found in ADHD children off MPH. When MPH was administered, the Stroop effect tended to appear. (2) The activation volume (AV) of prefrontal cortex (PFC) in both the neutral (NC) and interference conditions (IQ in ADHD children off MPH was smaller than in controls. AV of anterior cingulate cortex in the IC in ADHD children off MPH was smaller than that in controls, but was similar in the NC to that in controls. AV of the basal ganglia, insula and cerebellum was also smaller in the IC, but was larger in the NC for ADHD children off MPH compared with controls. These findings are consistent with prior findings of hypofrontality in ADHD children and implicate a compensatory network including basal ganglia, insula and cerebellum for relative lower cognitive load tasks. (c) 2005 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000234199200002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54797
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
2.306 Hosp, Dept MRI, Beijing 100101, Peoples R China
3.Massachusetts Mental Hlth Ctr, Boston, MA 02115 USA
4.Harvard Univ, Sch Med, Dept Psychiat, Cambridge, MA 02138 USA
5.Massachusetts Gen Hosp, Psychiat Serv, Boston, MA 02114 USA
6.Chinese Acad Sci, Inst Psychol, Lab Higher Brain Funct, Beijing 100101, Peoples R China
7.Harvard Univ, Inst Psychiat Epidemiol & Genet, Boston, MA 02115 USA
8.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100864, Peoples R China

Recommended Citation:
Zang, YF,Jin, Z,Weng, XC,et al. Functional MRI in attention-deficit hyperactivity disorder: Evidence for hypofrontality[J]. BRAIN & DEVELOPMENT,2005,27(8):544-550.
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