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Role of Estrogen Receptor-beta in Endometriosis
Bulun, Serdar E.1; Monsavais, Diana1; Pavone, Mary Ellen1; Dyson, Matthew1; Xue, Qing2; Attar, Erkut3; Tokunaga, Hideki4; Su, Emily J.1
关键词Er-beta Nuclear Receptor Estrogen Dna Methylation Epigenetic Promoter Er-alpha Pr
刊名SEMINARS IN REPRODUCTIVE MEDICINE
2012
DOI10.1055/s-0031-1299596
30期:1页:39-45
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Obstetrics & Gynecology ; Reproductive Biology
资助者NICHD ; NICHD
研究领域[WOS]Obstetrics & Gynecology ; Reproductive Biology
关键词[WOS]HUMAN PROGESTERONE-RECEPTOR ; MESSENGER-RIBONUCLEIC-ACID ; STEROIDOGENIC FACTOR-I ; BREAST-CANCER CELLS ; ELEMENT HALF-SITE ; GENE-EXPRESSION ; STROMAL CELLS ; PELVIC PAIN ; AROMATASE EXPRESSION ; ACTIVATOR PROTEIN-1
英文摘要

Endometriosis is an estrogen-dependent disease. The biologically active estrogen, estradiol, aggravates the pathological processes (e. g., inflammation and growth) and the symptoms (e. g., pain) associated with endometriosis. Abundant quantities of estradiol are available for endometriotic tissue via several mechanisms including local aromatase expression. The question remains, then, what mediates estradiol action. Because estrogen receptor (ER)beta levels in endometriosis are >100 times higher than those in endometrial tissue, this review focuses on this nuclear receptor. Deficient methylation of the ER beta promoter results in pathological overexpression of ER beta in endometriotic stromal cells. High levels of ER beta suppress ER alpha expression. A severely high ER beta-to-ER alpha ratio in endometriotic stromal cells is associated with suppressed progesterone receptor and increased cyclo-oxygenase-2 levels contributing to progesterone resistance and inflammation. ER beta-selective estradiol antagonists may serve as novel therapeutics of endometriosis in the future.

语种英语
所属项目编号R37-HD37691
资助者NICHD ; NICHD
WOS记录号WOS:000300255900007
引用统计
被引频次:73[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54801
专题北京大学第一临床医学院
作者单位1.Northwestern Univ, Feinberg Sch Med, Dept Obstet & Gynecol, Div Reprod Biol Res, Chicago, IL 60611 USA
2.Peking Univ, Hosp 1, Dept Obstet & Gynecol, Beijing 100871, Peoples R China
3.Istanbul Univ, Capa Sch Med, Dept Obstet & Gynecol, Div Reprod Endocrinol & Infertil, Istanbul, Turkey
4.Tohoku Univ, Sch Med, Dept Obstet & Gynecol, Sendai, Miyagi 980, Japan
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GB/T 7714
Bulun, Serdar E.,Monsavais, Diana,Pavone, Mary Ellen,et al. Role of Estrogen Receptor-beta in Endometriosis[J]. SEMINARS IN REPRODUCTIVE MEDICINE,2012,30(1):39-45.
APA Bulun, Serdar E..,Monsavais, Diana.,Pavone, Mary Ellen.,Dyson, Matthew.,Xue, Qing.,...&Su, Emily J..(2012).Role of Estrogen Receptor-beta in Endometriosis.SEMINARS IN REPRODUCTIVE MEDICINE,30(1),39-45.
MLA Bulun, Serdar E.,et al."Role of Estrogen Receptor-beta in Endometriosis".SEMINARS IN REPRODUCTIVE MEDICINE 30.1(2012):39-45.
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