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学科主题: 临床医学
题名:
Role of Estrogen Receptor-beta in Endometriosis
作者: Bulun, Serdar E.1; Monsavais, Diana1; Pavone, Mary Ellen1; Dyson, Matthew1; Xue, Qing2; Attar, Erkut3; Tokunaga, Hideki4; Su, Emily J.1
关键词: ER-beta ; nuclear receptor ; estrogen ; DNA methylation ; epigenetic ; promoter ; ER-alpha ; PR
刊名: SEMINARS IN REPRODUCTIVE MEDICINE
发表日期: 2012
DOI: 10.1055/s-0031-1299596
卷: 30, 期:1, 页:39-45
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Obstetrics & Gynecology ; Reproductive Biology
研究领域[WOS]: Obstetrics & Gynecology ; Reproductive Biology
关键词[WOS]: HUMAN PROGESTERONE-RECEPTOR ; MESSENGER-RIBONUCLEIC-ACID ; STEROIDOGENIC FACTOR-I ; BREAST-CANCER CELLS ; ELEMENT HALF-SITE ; GENE-EXPRESSION ; STROMAL CELLS ; PELVIC PAIN ; AROMATASE EXPRESSION ; ACTIVATOR PROTEIN-1
英文摘要:

Endometriosis is an estrogen-dependent disease. The biologically active estrogen, estradiol, aggravates the pathological processes (e. g., inflammation and growth) and the symptoms (e. g., pain) associated with endometriosis. Abundant quantities of estradiol are available for endometriotic tissue via several mechanisms including local aromatase expression. The question remains, then, what mediates estradiol action. Because estrogen receptor (ER)beta levels in endometriosis are >100 times higher than those in endometrial tissue, this review focuses on this nuclear receptor. Deficient methylation of the ER beta promoter results in pathological overexpression of ER beta in endometriotic stromal cells. High levels of ER beta suppress ER alpha expression. A severely high ER beta-to-ER alpha ratio in endometriotic stromal cells is associated with suppressed progesterone receptor and increased cyclo-oxygenase-2 levels contributing to progesterone resistance and inflammation. ER beta-selective estradiol antagonists may serve as novel therapeutics of endometriosis in the future.

语种: 英语
所属项目编号: R37-HD37691
项目资助者: NICHD
WOS记录号: WOS:000300255900007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54801
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Northwestern Univ, Feinberg Sch Med, Dept Obstet & Gynecol, Div Reprod Biol Res, Chicago, IL 60611 USA
2.Peking Univ, Hosp 1, Dept Obstet & Gynecol, Beijing 100871, Peoples R China
3.Istanbul Univ, Capa Sch Med, Dept Obstet & Gynecol, Div Reprod Endocrinol & Infertil, Istanbul, Turkey
4.Tohoku Univ, Sch Med, Dept Obstet & Gynecol, Sendai, Miyagi 980, Japan

Recommended Citation:
Bulun, Serdar E.,Monsavais, Diana,Pavone, Mary Ellen,et al. Role of Estrogen Receptor-beta in Endometriosis[J]. SEMINARS IN REPRODUCTIVE MEDICINE,2012,30(1):39-45.
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