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学科主题临床医学
Long-term intraocular pressure fluctuation of primary angle closure disease following laser peripheral iridotomy/iridoplasty
Chen Yan-yun1; Sun Lan-ping2; Thomas, Ravi3; Liang Yuan-bo4; Fan Su-jie2; Sun Xia1; Li Si-zhen1; Zhang Shao-dan5; Wang Ning-li1
关键词Primary Angle Closure Glaucoma Intraocular Pressure Fluctuation Peripheral Anterior Synechia
刊名CHINESE MEDICAL JOURNAL
2011-10-05
DOI10.3760/cma.j.issn.0366-6999.2011.19.021
124期:19页:3066-3069
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
资助者Ministry of Science and Technology of China ; Ministry of Science and Technology of China
研究领域[WOS]General & Internal Medicine
关键词[WOS]NORMAL-TENSION GLAUCOMA ; RISK-FACTOR ; PROGRESSION
英文摘要

Background Many studies indicated that short-term and long-term intraocular pressure (IOP) fluctuations in primary open angle glaucoma patients might lead to glaucomatous progression. However, seldom study has evaluated the long-term fluctuation of IOP in primary chronic angle closure diseases. The objective of this study was to investigate the long-term IOP fluctuation of primary angle closure diseases and its associations following laser peripheral iridotomy (LPI) with or without laser peripheral iridoplasty.

Methods A total of 158 patients with primary angle closure suspect (PACS, n=21), primary angle closure (PAC, n=81) and primary angle closure glaucoma (PACG, n=55) had been treated by LPI with or without laser peripheral iridoplasty and followed up for more than 12 months. IOP was measured with Goldman applanation tonometer. Multivariate linear regression with generalized estimating equation (GEE) regression models was used to evaluate the association of long-term IOP fluctuation (maximum IOP minus minimum IOP) with gender, age, baseline IOP, baseline peripheral anterior synechia (PAS), baseline vertical cup/disc ratio (VCDR), baseline mean deviation (MD), need for IOP-lowering medications.

Results IOP fluctuation during follow-up in PACS, PAC and PACG groups were (4.83+/-2.90), (5.67+/-3.35), and (9.40+/-7.14) mmHg, respectively. IOP fluctuation was strongly correlated with baseline IOP (r=0.356, P <0.001), PAS (r=0.374, P <0.001). IOP fluctuation was higher in patients with higher baseline IOP (0.18 mmHg per unit increase, 95% CI: 0.05-0.31 mmHg).

Conclusions Long-term IOP fluctuation in PACG group was larger than that in PACS or PAC group. Eyes with higher baseline IOP were observed to have larger long-term IOP fluctuation. Chin Med J 2011;124(19):3066-3069

语种英语
所属项目编号2007BAI18B08
资助者Ministry of Science and Technology of China ; Ministry of Science and Technology of China
WOS记录号WOS:000296307600022
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54805
Collection北京大学第三临床医学院_眼科
作者单位1.Handan Eye Hosp, Handan 056001, Hebei, Peoples R China
2.Capital Med Univ, Beijing Tongren Hosp, Beijing Tongren Eye Ctr, Beijing Ophthalmol & Vis Sci Key Lab, Beijing 100730, Peoples R China
3.Univ Queensland, Queensland Eye Inst, Brisbane, Qld 4101, Australia
4.Chinese Univ Hong Kong, Dept Ophthalmol & Visual Sci, Hong Kong, Hong Kong, Peoples R China
5.Peking Univ, Hosp 3, Dept Ophthalmol, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Chen Yan-yun,Sun Lan-ping,Thomas, Ravi,et al. Long-term intraocular pressure fluctuation of primary angle closure disease following laser peripheral iridotomy/iridoplasty[J]. CHINESE MEDICAL JOURNAL,2011,124(19):3066-3069.
APA Chen Yan-yun.,Sun Lan-ping.,Thomas, Ravi.,Liang Yuan-bo.,Fan Su-jie.,...&Wang Ning-li.(2011).Long-term intraocular pressure fluctuation of primary angle closure disease following laser peripheral iridotomy/iridoplasty.CHINESE MEDICAL JOURNAL,124(19),3066-3069.
MLA Chen Yan-yun,et al."Long-term intraocular pressure fluctuation of primary angle closure disease following laser peripheral iridotomy/iridoplasty".CHINESE MEDICAL JOURNAL 124.19(2011):3066-3069.
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