IR@PKUHSC  > 北京大学精神卫生研究所
学科主题精神卫生
Hyperforin promotes nnitochondrial function and development of oligodendrocytes
Wang, Yanlin2; Zhang, Yanbo2; He, Jue; Zhang, Handi; Xiao, Lan3; Nazarali, Adil4; Zhang, Zhijun6; Zhang, Dai5; Tan, Qingrong7; Kong, Jiming3,8; Li, Xin-Min1,2,3,8
关键词Development Hyperforin Mitochondrial Function Oligodendrocyte St. John&Prime s Wort
刊名JOURNAL OF NEUROCHEMISTRY
2011-11-01
DOI10.1111/j.1471-4159.2011.07433.x
119期:3页:555-568
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Neurosciences
研究领域[WOS]Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]ST-JOHNS-WORT ; MAJOR DEPRESSIVE DISORDER ; MITOCHONDRIAL COMPLEX-I ; TRANSCRIPTION FACTOR ; CELL-PROLIFERATION ; PPAR-GAMMA ; HYPERICUM-PERFORATUM ; PREFRONTAL CORTEX ; FRONTAL-CORTEX ; RAT-BRAIN
英文摘要

St. John′s wort has been found to be an effective and safe herbal treatment for depression in several clinical trails. However, the underlying mechanism of its therapeutic effects is unclear. Recent studies show that the loss and malfunction of oligodendrocytes are closely related to the neuropathological changes in depression, which can be reversed by anti-depressant treatment. In this study, we evaluated the effects of hyperforin, a major active component of St. John′s wort, on the proliferation, development and mitochondrial function of oligodendrocytes. The study results revealed that hyperforin promotes maturation of oligodendrocytes ad increases mitochondrial function without affecting proliferation of an oligodendrocyte progenitor cell line and neural stem/progenitor cells. Hyperforin also prevented mitochondrial toxin-induced cytotoxicity in an oligodendrocyte progenitor cell line. These findings suggest that hyperforin may stimulate the development and function of oligodendrocytes, which could be a mechanism of its effect in depression. Future in vitro and in vivo studies are required to further characterize the mechanisms of hyperforin.

语种英语
WOS记录号WOS:000297019300012
项目编号81061120529
资助机构Canadian Institutes of Health Research ; CIHR-NSFC ; CIHR-MOST Team
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54807
专题北京大学精神卫生研究所
作者单位1.Univ Manitoba, Fac Med, Dept Psychiat, Winnipeg, MB, Canada
2.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
3.Univ Saskatchewan, Dept Psychiat, Saskatoon, SK S7N 0W0, Canada
4.Third Mil Med Univ, Dept Hist & Embryol, Chongqing, Peoples R China
5.Univ Saskatchewan, Div Pharm, Coll Pharm & Nutr, Saskatoon, SK, Canada
6.Southeast Univ, Dept Neuropsychiat, ZhongDa Hosp, Nanjing, Peoples R China
7.Fourth Mil Med Univ, Xijing Hosp, Dept Psychiat, Xian 710032, Peoples R China
8.Univ Manitoba, Dept Human Anat & Cell Sci, Winnipeg, MB, Canada
推荐引用方式
GB/T 7714
Wang, Yanlin,Zhang, Yanbo,He, Jue,et al. Hyperforin promotes nnitochondrial function and development of oligodendrocytes[J]. JOURNAL OF NEUROCHEMISTRY,2011,119(3):555-568.
APA Wang, Yanlin.,Zhang, Yanbo.,He, Jue.,Zhang, Handi.,Xiao, Lan.,...&Li, Xin-Min.(2011).Hyperforin promotes nnitochondrial function and development of oligodendrocytes.JOURNAL OF NEUROCHEMISTRY,119(3),555-568.
MLA Wang, Yanlin,et al."Hyperforin promotes nnitochondrial function and development of oligodendrocytes".JOURNAL OF NEUROCHEMISTRY 119.3(2011):555-568.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang, Yanlin]的文章
[Zhang, Yanbo]的文章
[He, Jue]的文章
百度学术
百度学术中相似的文章
[Wang, Yanlin]的文章
[Zhang, Yanbo]的文章
[He, Jue]的文章
必应学术
必应学术中相似的文章
[Wang, Yanlin]的文章
[Zhang, Yanbo]的文章
[He, Jue]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。