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学科主题: 精神卫生
题名:
Hyperforin promotes nnitochondrial function and development of oligodendrocytes
作者: Wang, Yanlin2; Zhang, Yanbo2; He, Jue; Zhang, Handi; Xiao, Lan3; Nazarali, Adil4; Zhang, Zhijun6; Zhang, Dai5; Tan, Qingrong7; Kong, Jiming3,8; Li, Xin-Min1,2,3,8
关键词: development ; hyperforin ; mitochondrial function ; oligodendrocyte ; St. John&prime ; s wort
刊名: JOURNAL OF NEUROCHEMISTRY
发表日期: 2011-11-01
DOI: 10.1111/j.1471-4159.2011.07433.x
卷: 119, 期:3, 页:555-568
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Neurosciences
研究领域[WOS]: Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]: ST-JOHNS-WORT ; MAJOR DEPRESSIVE DISORDER ; MITOCHONDRIAL COMPLEX-I ; TRANSCRIPTION FACTOR ; CELL-PROLIFERATION ; PPAR-GAMMA ; HYPERICUM-PERFORATUM ; PREFRONTAL CORTEX ; FRONTAL-CORTEX ; RAT-BRAIN
英文摘要:

St. John′s wort has been found to be an effective and safe herbal treatment for depression in several clinical trails. However, the underlying mechanism of its therapeutic effects is unclear. Recent studies show that the loss and malfunction of oligodendrocytes are closely related to the neuropathological changes in depression, which can be reversed by anti-depressant treatment. In this study, we evaluated the effects of hyperforin, a major active component of St. John′s wort, on the proliferation, development and mitochondrial function of oligodendrocytes. The study results revealed that hyperforin promotes maturation of oligodendrocytes ad increases mitochondrial function without affecting proliferation of an oligodendrocyte progenitor cell line and neural stem/progenitor cells. Hyperforin also prevented mitochondrial toxin-induced cytotoxicity in an oligodendrocyte progenitor cell line. These findings suggest that hyperforin may stimulate the development and function of oligodendrocytes, which could be a mechanism of its effect in depression. Future in vitro and in vivo studies are required to further characterize the mechanisms of hyperforin.

语种: 英语
所属项目编号: 81061120529
项目资助者: Canadian Institutes of Health Research ; CIHR-NSFC ; CIHR-MOST Team
WOS记录号: WOS:000297019300012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54807
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Univ Manitoba, Fac Med, Dept Psychiat, Winnipeg, MB, Canada
2.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
3.Univ Saskatchewan, Dept Psychiat, Saskatoon, SK S7N 0W0, Canada
4.Third Mil Med Univ, Dept Hist & Embryol, Chongqing, Peoples R China
5.Univ Saskatchewan, Div Pharm, Coll Pharm & Nutr, Saskatoon, SK, Canada
6.Southeast Univ, Dept Neuropsychiat, ZhongDa Hosp, Nanjing, Peoples R China
7.Fourth Mil Med Univ, Xijing Hosp, Dept Psychiat, Xian 710032, Peoples R China
8.Univ Manitoba, Dept Human Anat & Cell Sci, Winnipeg, MB, Canada

Recommended Citation:
Wang, Yanlin,Zhang, Yanbo,He, Jue,et al. Hyperforin promotes nnitochondrial function and development of oligodendrocytes[J]. JOURNAL OF NEUROCHEMISTRY,2011,119(3):555-568.
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