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Aquaporin-5 water channel in lipid rafts of rat parotid glands
Ishikawa, Yasuko; Cho, Gota; Yuan, Zhenfang; Inoue, Noriko; Nakae, Yoshiko
关键词Aquaporin-5 Lipid Rafts Parotid Glands Diabetes Aging Interlobular Ducts
刊名BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
2006-08-01
DOI10.1016/j.bbamem.2006.03.026
1758期:8页:1053-1060
收录类别ISTP ; SCI
文章类型Proceedings Paper
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]APICAL PLASMA-MEMBRANE ; FLUORESCENT DYE SULFORHODAMINE ; LASER-SCANNING MICROSCOPE ; GPI-ANCHORED PROTEINS ; MOLECULAR-MECHANISMS ; DRUG DEVELOPMENT ; EPITHELIAL-CELLS ; ACINAR-CELLS ; NITRIC-OXIDE ; DEPENDENT MOBILIZATION
英文摘要

Aquaporin-5 (AQP5), an apical plasma membrane (APM) water channel in salivary glands, lacrimal glands, and airway epithelium, has an important role in fluid secretion. The activation of M3 muscarinic acetylcholine receptors (mAChRs) or alpha 1-adrenoceptors on the salivary glands induces salivary fluid secretion. AQP5 localizes in lipid rafts and activation of the M3 mACbRs or alpha 1-adrenoceptors induced its translocation together with the lipid rafts to the APM in the interlobular ducts of rat parotid glands. This review focuses on the mechanisms of AQP5 translocation together with lipid rafts to the APM in the interlobular duct cells of parotid glands of normal rats and the impairment of AQP5 translocation in diabetes and senescence. (c) 2006 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000241272900011
引用统计
被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54810
专题北京大学第一临床医学院_大内科
作者单位1.Univ Tokushima, Inst Hlth Biosci, Dept Med Pharmacol, Tokushima 7708504, Japan
2.Univ Tokushima, Grad Sch, Inst Hlth Biosci, Tokushima 7708504, Japan
3.Peking Univ, Hosp 1, Dept Internal Med, Beijing 100034, Peoples R China
4.Univ Tokushima, Med & Dent Hosp, Dept Oral Care & Clin Educ, Tokushima 7708504, Japan
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Ishikawa, Yasuko,Cho, Gota,Yuan, Zhenfang,et al. Aquaporin-5 water channel in lipid rafts of rat parotid glands[J]. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES,2006,1758(8):1053-1060.
APA Ishikawa, Yasuko,Cho, Gota,Yuan, Zhenfang,Inoue, Noriko,&Nakae, Yoshiko.(2006).Aquaporin-5 water channel in lipid rafts of rat parotid glands.BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES,1758(8),1053-1060.
MLA Ishikawa, Yasuko,et al."Aquaporin-5 water channel in lipid rafts of rat parotid glands".BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 1758.8(2006):1053-1060.
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