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学科主题: 临床医学
题名:
Aquaporin-5 water channel in lipid rafts of rat parotid glands
作者: Ishikawa, Yasuko; Cho, Gota; Yuan, Zhenfang; Inoue, Noriko; Nakae, Yoshiko
关键词: aquaporin-5 ; lipid rafts ; parotid glands ; diabetes ; aging ; interlobular ducts
刊名: BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
发表日期: 2006-08-01
DOI: 10.1016/j.bbamem.2006.03.026
卷: 1758, 期:8, 页:1053-1060
收录类别: ISTP ; SCI
文章类型: Proceedings Paper
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: APICAL PLASMA-MEMBRANE ; FLUORESCENT DYE SULFORHODAMINE ; LASER-SCANNING MICROSCOPE ; GPI-ANCHORED PROTEINS ; MOLECULAR-MECHANISMS ; DRUG DEVELOPMENT ; EPITHELIAL-CELLS ; ACINAR-CELLS ; NITRIC-OXIDE ; DEPENDENT MOBILIZATION
英文摘要:

Aquaporin-5 (AQP5), an apical plasma membrane (APM) water channel in salivary glands, lacrimal glands, and airway epithelium, has an important role in fluid secretion. The activation of M3 muscarinic acetylcholine receptors (mAChRs) or alpha 1-adrenoceptors on the salivary glands induces salivary fluid secretion. AQP5 localizes in lipid rafts and activation of the M3 mACbRs or alpha 1-adrenoceptors induced its translocation together with the lipid rafts to the APM in the interlobular ducts of rat parotid glands. This review focuses on the mechanisms of AQP5 translocation together with lipid rafts to the APM in the interlobular duct cells of parotid glands of normal rats and the impairment of AQP5 translocation in diabetes and senescence. (c) 2006 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000241272900011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54810
Appears in Collections:北京大学第一临床医学院_大内科_期刊论文

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作者单位: 1.Univ Tokushima, Inst Hlth Biosci, Dept Med Pharmacol, Tokushima 7708504, Japan
2.Univ Tokushima, Grad Sch, Inst Hlth Biosci, Tokushima 7708504, Japan
3.Peking Univ, Hosp 1, Dept Internal Med, Beijing 100034, Peoples R China
4.Univ Tokushima, Med & Dent Hosp, Dept Oral Care & Clin Educ, Tokushima 7708504, Japan

Recommended Citation:
Ishikawa, Yasuko,Cho, Gota,Yuan, Zhenfang,et al. Aquaporin-5 water channel in lipid rafts of rat parotid glands[J]. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES,2006,1758(8):1053-1060.
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