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学科主题临床医学
Effects of salicylate on transient outward and delayed rectifier potassium channels in rat inferior colliculus neurons
Liu, YX; Li, XP
关键词Salicylate Tinnitus Inferior Colliculus Potassium Current Patch Clamp
刊名NEUROSCIENCE LETTERS
2004-10-14
DOI10.1016/j.neulet.2004.07.037
369期:2页:115-120
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]CURRENTS ; TINNITUS ; MODEL ; CELLS
英文摘要

The effects of salicylate (a tinnitus inducer) were studied on the transient outward potassium current (I-K(A)) and the delayed rectifier potassium current (I-K(DR)) in acutely dissociated rat inferior colliculus neurons by the whole-cell voltage-clamp method. Salicylate′s inhibition of the amplitude Of I-K(A) and I-K(DR) was concentration-dependent. The IC50 values for the blocking action of salicylate on I-K(A) and I-K(DR) were 2.27 and 0.80 mM, respectively. At a concentration of I mM, salicylate significantly shifted the activation and inactivation Curves Of I-K(DR) negatively by approximately 11 and 24 mV, respectively, but did not shift the I-K(A) curves. In conclusion, salicylate inhibits both I-K(A) and IK(DR) in rat inferior colliculus neurons but only significantly affects the activation and inactivation kinetics Of I-K(DR). Depression Of I-K(DR) by salicylate may play an important role in salicylate-induced tinnitus. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000224438100006
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被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54812
专题北京大学第三临床医学院_耳鼻喉科
作者单位Peking Univ, 3rd Hosp, Dept Otorhinolaryngol, Beijing 100083, Peoples R China
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GB/T 7714
Liu, YX,Li, XP. Effects of salicylate on transient outward and delayed rectifier potassium channels in rat inferior colliculus neurons[J]. NEUROSCIENCE LETTERS,2004,369(2):115-120.
APA Liu, YX,&Li, XP.(2004).Effects of salicylate on transient outward and delayed rectifier potassium channels in rat inferior colliculus neurons.NEUROSCIENCE LETTERS,369(2),115-120.
MLA Liu, YX,et al."Effects of salicylate on transient outward and delayed rectifier potassium channels in rat inferior colliculus neurons".NEUROSCIENCE LETTERS 369.2(2004):115-120.
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