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学科主题: 药学
题名:
Self-Assembled Polymeric Micellar Nanoparticles as Nanocarriers for Poorly Soluble Anticancer Drug Ethaselen
作者: Li, Xinru1; Yang, Zhuoli2; Yang, Kewei3; Zhou, Yanxia1; Chen, Xingwei1; Zhang, Yanhui1; Wang, Fei1; Liu, Yan1; Ren, Lijun4
关键词: Monomethoxy poly(ethylene glycol)-poly(lactide) ; Polymeric micelles ; Hemolysis ; Ethaselen ; Antitumor efficacy
刊名: NANOSCALE RESEARCH LETTERS
发表日期: 2009-12-01
DOI: 10.1007/s11671-009-9427-2
卷: 4, 期:12, 页:1502-1511
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
研究领域[WOS]: Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]: BLOCK-COPOLYMER MICELLES ; POLY(ETHYLENE GLYCOL) ; DIBLOCK COPOLYMERS ; METHOXYPOLYETHYLENE GLYCOL ; NUDE-MICE ; IN-VITRO ; CARRIERS ; DELIVERY ; TUMOR ; ADRIAMYCIN
英文摘要:

A series of monomethoxy poly(ethylene glycol)-poly(lactide) (mPEG-PLA) diblock copolymers were synthesized, and mPEG-PLA micelle was fabricated and used as a nanocarrier for solubilization and delivery of a promising anticancer drug ethaselen. Ethaselen was efficiently encapsulated into the micelles by the dialysis method, and the solubility of ethaselen in water was remarkably increased up to 82 mu g/mL before freeze-drying. The mean diameter of ethaselen-loaded micelles ranged from 51 to 98 nm with a narrow size distribution and depended on the length of PLA block. In vitro hemolysis study indicated that mPEG-PLA copolymers and ethaselen-loaded polymeric micelles had no hemolytic effect on the erythrocyte. The enhanced antitumor efficacy and reduced toxic effect of ethaselen-loaded polymeric micelle when compared with ethaselen-HP-beta-CD inclusion were observed at the same dose in H(22) human liver cancer cell bearing mouse models. These suggested that mPEG-PLA polymeric micelle nanoparticles had great potential as nanocarriers for effective solubilization of poorly soluble ethaselen and further reducing side effects and toxicities of the drug.

语种: 英语
WOS记录号: WOS:000272121500017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54816
Appears in Collections:北京大学药学院_药剂学系_期刊论文

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作者单位: 1.TEAM Acad Pharmaceut Sci, Beijing, Peoples R China
2.Inst Chem Def, Dept 3, Beijing, Peoples R China
3.Peking Univ, Dept Pharmaceut, Sch Pharmaceut Sci, Beijing 100191, Haidian, Peoples R China
4.Univ Jena, Dept Pharmaceut Technol, Inst Pharm, Jena, Germany

Recommended Citation:
Li, Xinru,Yang, Zhuoli,Yang, Kewei,et al. Self-Assembled Polymeric Micellar Nanoparticles as Nanocarriers for Poorly Soluble Anticancer Drug Ethaselen[J]. NANOSCALE RESEARCH LETTERS,2009,4(12):1502-1511.
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