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Self-Assembled Polymeric Micellar Nanoparticles as Nanocarriers for Poorly Soluble Anticancer Drug Ethaselen
Li, Xinru1; Yang, Zhuoli2; Yang, Kewei3; Zhou, Yanxia1; Chen, Xingwei1; Zhang, Yanhui1; Wang, Fei1; Liu, Yan1; Ren, Lijun4
关键词Monomethoxy Poly(Ethylene Glycol)-Poly(Lactide) Polymeric Micelles Hemolysis Ethaselen Antitumor Efficacy
刊名NANOSCALE RESEARCH LETTERS
2009-12-01
DOI10.1007/s11671-009-9427-2
4期:12页:1502-1511
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
研究领域[WOS]Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]BLOCK-COPOLYMER MICELLES ; POLY(ETHYLENE GLYCOL) ; DIBLOCK COPOLYMERS ; METHOXYPOLYETHYLENE GLYCOL ; NUDE-MICE ; IN-VITRO ; CARRIERS ; DELIVERY ; TUMOR ; ADRIAMYCIN
英文摘要

A series of monomethoxy poly(ethylene glycol)-poly(lactide) (mPEG-PLA) diblock copolymers were synthesized, and mPEG-PLA micelle was fabricated and used as a nanocarrier for solubilization and delivery of a promising anticancer drug ethaselen. Ethaselen was efficiently encapsulated into the micelles by the dialysis method, and the solubility of ethaselen in water was remarkably increased up to 82 mu g/mL before freeze-drying. The mean diameter of ethaselen-loaded micelles ranged from 51 to 98 nm with a narrow size distribution and depended on the length of PLA block. In vitro hemolysis study indicated that mPEG-PLA copolymers and ethaselen-loaded polymeric micelles had no hemolytic effect on the erythrocyte. The enhanced antitumor efficacy and reduced toxic effect of ethaselen-loaded polymeric micelle when compared with ethaselen-HP-beta-CD inclusion were observed at the same dose in H(22) human liver cancer cell bearing mouse models. These suggested that mPEG-PLA polymeric micelle nanoparticles had great potential as nanocarriers for effective solubilization of poorly soluble ethaselen and further reducing side effects and toxicities of the drug.

语种英语
WOS记录号WOS:000272121500017
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被引频次:45[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54816
专题北京大学药学院_药剂学系
作者单位1.TEAM Acad Pharmaceut Sci, Beijing, Peoples R China
2.Inst Chem Def, Dept 3, Beijing, Peoples R China
3.Peking Univ, Dept Pharmaceut, Sch Pharmaceut Sci, Beijing 100191, Haidian, Peoples R China
4.Univ Jena, Dept Pharmaceut Technol, Inst Pharm, Jena, Germany
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GB/T 7714
Li, Xinru,Yang, Zhuoli,Yang, Kewei,et al. Self-Assembled Polymeric Micellar Nanoparticles as Nanocarriers for Poorly Soluble Anticancer Drug Ethaselen[J]. NANOSCALE RESEARCH LETTERS,2009,4(12):1502-1511.
APA Li, Xinru.,Yang, Zhuoli.,Yang, Kewei.,Zhou, Yanxia.,Chen, Xingwei.,...&Ren, Lijun.(2009).Self-Assembled Polymeric Micellar Nanoparticles as Nanocarriers for Poorly Soluble Anticancer Drug Ethaselen.NANOSCALE RESEARCH LETTERS,4(12),1502-1511.
MLA Li, Xinru,et al."Self-Assembled Polymeric Micellar Nanoparticles as Nanocarriers for Poorly Soluble Anticancer Drug Ethaselen".NANOSCALE RESEARCH LETTERS 4.12(2009):1502-1511.
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