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学科主题: 临床医学
题名:
No effect of embryo culture media on birthweight and length of newborns
作者: Lin, Shengli1,2,3; Li, Ming1,2,3; Lian, Ying1,2,3; Chen, Lixue1,2,3; Liu, Ping1,2,3
关键词: IVF ; embryo culture medium ; birthweight ; birth length
刊名: HUMAN REPRODUCTION
发表日期: 2013-07-01
DOI: 10.1093/humrep/det095
卷: 28, 期:7, 页:1762-1767
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Obstetrics & Gynecology ; Reproductive Biology
研究领域[WOS]: Obstetrics & Gynecology ; Reproductive Biology
关键词[WOS]: BECKWITH-WIEDEMANN-SYNDROME ; IN-VITRO CULTURE ; CHINESE POPULATION ; IMPRINTED GENES ; PRETERM BIRTH ; IVF ; EXPRESSION
英文摘要:

Does the type of media used to culture embryos for IVF influence the birthweight and length of neonates?

No significant differences were observed in birthweight and length among the three embryo culture media used for in vitro embryo culture.

Since the establishment of IVF as an assisted reproductive technology (ART), many different culture systems have been used for the development of human embryos. Some studies have shown that the types of culture media influence the newborn birthweight; however, other studies have shown no effect. To further explore this contradictory issue, we compared the birthweight and length of neonates born after the transfer of embryos cultured in one of three commercially available media.

This retrospective analysis of birthweight and length of newborns included 1201 women who delivered singletons and 445 women who delivered twins. The following three commercially available culture media were used: G5, Global and Quinns advantage media. Women who underwent IVF-ET cycles between 2008 and 2010 were analyzed.

Patients younger than 40 years of age with a body mass index (BMI) 30 kg/m(2) were analyzed. Only data from singletons and twins born alive after the 20th week of gestation were included in the data analysis. Patients who received preimplantation genetic diagnosis (PGD) and donor oocytes were excluded.

The analysis of 1201 singletons and 445 sets of twins showed no significant association between mean birthweight or mean birth length and the type of embryo culture medium. Inter-twin mean birthweight and length disparities were analyzed, but were not shown to be significantly different. Multiple linear regression analysis showed that maternal weight, maternal height, gestational age and infant gender were significantly related to birthweight, and paternal height, gestational age and newborn complications were significantly associated with birth length.

The current study showed that birthweight and length of newborns were not associated with the embryo culture medium. More research needs to be performed to analyze the effects of other culture medium formulations and to evaluate the long-term effects of embryo culture medium on the health of children conceived through ART.

Our retrospective study suggests that embryo culture medium does not influence neonatal birthweight and length; however, the effects of culture medium on epigenetic variation of embryos need to be studied further.

This study was funded by National Natural Science Foundation of China (81070534) and National Natural Science Foundation of China for Young Scholars (81200437). The authors have no conflicts of interest to declare.

语种: 英语
所属项目编号: 81070534 ; 81200437
项目资助者: National Natural Science Foundation of China ; National Natural Science Foundation of China for Young Scholars
WOS记录号: WOS:000320855600004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54820
Appears in Collections:北京大学第三临床医学院_生殖医学中心_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Reprod Med Ctr, Dept Obstet & Gynecol, Beijing 100191, Peoples R China
2.Minist Educ, Key Lab Assisted Reprod, Beijing, Peoples R China
3.Beijing Key Lab Reprod Endocrinol & Assisted Repr, Beijing, Peoples R China

Recommended Citation:
Lin, Shengli,Li, Ming,Lian, Ying,et al. No effect of embryo culture media on birthweight and length of newborns[J]. HUMAN REPRODUCTION,2013,28(7):1762-1767.
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