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Expression profiles of adhesion molecules on naive T cells in bone marrow grafts of healthy donors treated with granulocyte colony-stimulating factor
Chang, Ying-Jun; Zhao, Xiang-Yu; Huo, Ming-Rui; Huang, Xiao-Jun
关键词Adhesion Molecules Granulocyte Colony-stimulating Factor Naive t Cells
刊名TRANSPLANT IMMUNOLOGY
2009-09-01
DOI10.1016/j.trim.2009.05.005
21期:4页:228-233
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology ; Transplantation
研究领域[WOS]Immunology ; Transplantation
关键词[WOS]VERSUS-HOST-DISEASE ; G-CSF ; LYMPHOCYTE FUNCTION ; L-SELECTIN ; BLOOD ; TRANSPLANTATION ; ACTIVATION ; ANTIBODIES ; GLOBULIN ; LEUKEMIA
英文摘要

Background and objectives: Adhesion molecules on T cells were implicated in the process of leukocyte migration and GVHD. The aim of this study was to investigate the profiles of adhesion molecule expression on naive T cells in bone marrow grafts of healthy donors treated with G-CSF.

Methods: The expression of four adhesion molecules, including VLA-4, ICAM-1, L-selectin, and LFA-1, on naive T cells in G-CSF-primed bone marrow grafts (G-BM) from 35 healthy donors was analyzed using flow cytometry.

Results: G-CSF administration significantly decreased the expression of VLA-4, ICAM-1, L-selectin, and LFA-1 on naive CD4(+) and CD8(+) T cells in bone marrow grafts. Treating healthy donors with G-CSF significantly increased the percentages of interleukin-4 (IL-4) positive cells in naive CD4(+) and CD8(+) T cell subsets, leading to polarization of bone marrow naive CD4(+) and CD8(+) T cells from Th1 to Th2 phenotype.

Conclusions: Our results suggest that CD4(+) and CD8(+) naive T cells in G-BM have lower intensities of expression of several adhesion molecules. The clinical significance of these alteration warrants further study. (C) 2009 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000270073000008
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54822
专题北京大学第二临床医学院_血液科
作者单位Peking Univ, Peoples Hosp, Inst Hematol, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Chang, Ying-Jun,Zhao, Xiang-Yu,Huo, Ming-Rui,et al. Expression profiles of adhesion molecules on naive T cells in bone marrow grafts of healthy donors treated with granulocyte colony-stimulating factor[J]. TRANSPLANT IMMUNOLOGY,2009,21(4):228-233.
APA Chang, Ying-Jun,Zhao, Xiang-Yu,Huo, Ming-Rui,&Huang, Xiao-Jun.(2009).Expression profiles of adhesion molecules on naive T cells in bone marrow grafts of healthy donors treated with granulocyte colony-stimulating factor.TRANSPLANT IMMUNOLOGY,21(4),228-233.
MLA Chang, Ying-Jun,et al."Expression profiles of adhesion molecules on naive T cells in bone marrow grafts of healthy donors treated with granulocyte colony-stimulating factor".TRANSPLANT IMMUNOLOGY 21.4(2009):228-233.
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