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Elevated Lysosome-associated Protein Transmembrane-4 beta-35 is an Independent Prognostic Marker in Pancreatic Carcinoma
Zhang, G.1,2,3,4; Liang, Y.5; Huang, Y.1,2,3,4; Chen, Y.1,2,3,4; Zhou, R.6
关键词Lysosome-associated Protein Transmembrane-4 Beta-35 Laptm4b Gene Immunohistochemistry Pancreatic Carcinoma Survival
刊名JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
2012-07-01
40期:4页:1275-1283
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]HEPATOCELLULAR-CARCINOMA ; RISK-FACTORS ; GALLBLADDER CARCINOMA ; CANCER STATISTICS ; IN-VITRO ; LAPTM4B-35 ; OVEREXPRESSION ; EXPRESSION ; PROGRESSION ; THERAPIES
英文摘要

OBJECTIVES: To investigate the relationship between lysosome-associated protein transmembrane-4 beta-35 (LAPTM4B-35) and the clinicopathological features and prognosis of pancreatic carcinoma. METHODS: The level of LAPTM4B-35 protein was determined by semi-quantitative immunohistochemistry in pancreatic carcinoma specimens. The relationship between LAPTM4B-35 level and prognosis was determined using univariate and multivariate analyses. RESULTS: A total of 98 patient samples were included. The presence of LAPTM4B-35 protein was confirmed in 77/98 (78.6%) patients and was significantly associated with tumour stage, degree of differentiation and pathological staging of pancreatic carcinoma after primary surgery. Patients with high LAPTM4B-35 levels had a poorer overall survival compared with patients with lower levels. Multivariate analysis showed that LAPTM4B-35 was an independent prognostic factor for overall survival. CONCLUSIONS: LAPTM4B-35 was found to be present at high levels in a large proportion of patients with pancreatic carcinoma, and was closely related to disease progression and poor prognosis. LAPTM4B-35 may represent a new molecular target for the clinical evaluation and treatment of pancreatic carcinoma.

语种英语
WOS记录号WOS:000309192900006
项目编号2009Y0021 ; 09ZD017
资助机构Key Sci-Tech Research Foundation of Fujian Province ; Major Scientific Research Foundation of the Fujian Medical University
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54827
专题北京大学深圳医院_药学部
作者单位1.Fujian Med Univ, Dept Hepatobiliary Surg, Union Clin Med Coll, Fuzhou 350001, Fujian Province, Peoples R China
2.Fujian Med Univ, Hepatobiliary Surg Inst, Union Clin Med Coll, Fuzhou 350001, Fujian Province, Peoples R China
3.Fujian Med Univ, Affiliated Union Hosp, Fuzhou 350001, Fujian Province, Peoples R China
4.Fujian Med Univ, Key Lab Gastrointestinal Canc, Minist Educ, Mol Med Res Ctr, Fuzhou 350001, Fujian Province, Peoples R China
5.Peking Univ, Shenzhen Hosp, Dept Pharm, Shenzhen, Peoples R China
6.Peking Univ, Dept Cell Biol, Sch Basic Med Sci, Beijing 100871, Peoples R China
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GB/T 7714
Zhang, G.,Liang, Y.,Huang, Y.,et al. Elevated Lysosome-associated Protein Transmembrane-4 beta-35 is an Independent Prognostic Marker in Pancreatic Carcinoma[J]. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,2012,40(4):1275-1283.
APA Zhang, G.,Liang, Y.,Huang, Y.,Chen, Y.,&Zhou, R..(2012).Elevated Lysosome-associated Protein Transmembrane-4 beta-35 is an Independent Prognostic Marker in Pancreatic Carcinoma.JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,40(4),1275-1283.
MLA Zhang, G.,et al."Elevated Lysosome-associated Protein Transmembrane-4 beta-35 is an Independent Prognostic Marker in Pancreatic Carcinoma".JOURNAL OF INTERNATIONAL MEDICAL RESEARCH 40.4(2012):1275-1283.
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