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学科主题: 药学
题名:
Elevated Lysosome-associated Protein Transmembrane-4 beta-35 is an Independent Prognostic Marker in Pancreatic Carcinoma
作者: Zhang, G.1,2,3,4; Liang, Y.5; Huang, Y.1,2,3,4; Chen, Y.1,2,3,4; Zhou, R.6
关键词: LYSOSOME-ASSOCIATED PROTEIN TRANSMEMBRANE-4 beta-35 ; LAPTM4B GENE ; IMMUNOHISTOCHEMISTRY ; PANCREATIC CARCINOMA ; SURVIVAL
刊名: JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
发表日期: 2012-07-01
卷: 40, 期:4, 页:1275-1283
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]: Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]: HEPATOCELLULAR-CARCINOMA ; RISK-FACTORS ; GALLBLADDER CARCINOMA ; CANCER STATISTICS ; IN-VITRO ; LAPTM4B-35 ; OVEREXPRESSION ; EXPRESSION ; PROGRESSION ; THERAPIES
英文摘要:

OBJECTIVES: To investigate the relationship between lysosome-associated protein transmembrane-4 beta-35 (LAPTM4B-35) and the clinicopathological features and prognosis of pancreatic carcinoma. METHODS: The level of LAPTM4B-35 protein was determined by semi-quantitative immunohistochemistry in pancreatic carcinoma specimens. The relationship between LAPTM4B-35 level and prognosis was determined using univariate and multivariate analyses. RESULTS: A total of 98 patient samples were included. The presence of LAPTM4B-35 protein was confirmed in 77/98 (78.6%) patients and was significantly associated with tumour stage, degree of differentiation and pathological staging of pancreatic carcinoma after primary surgery. Patients with high LAPTM4B-35 levels had a poorer overall survival compared with patients with lower levels. Multivariate analysis showed that LAPTM4B-35 was an independent prognostic factor for overall survival. CONCLUSIONS: LAPTM4B-35 was found to be present at high levels in a large proportion of patients with pancreatic carcinoma, and was closely related to disease progression and poor prognosis. LAPTM4B-35 may represent a new molecular target for the clinical evaluation and treatment of pancreatic carcinoma.

语种: 英语
所属项目编号: 2009Y0021 ; 09ZD017
项目资助者: Key Sci-Tech Research Foundation of Fujian Province ; Major Scientific Research Foundation of the Fujian Medical University
WOS记录号: WOS:000309192900006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54827
Appears in Collections:北京大学深圳医院_药学部_期刊论文

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作者单位: 1.Fujian Med Univ, Dept Hepatobiliary Surg, Union Clin Med Coll, Fuzhou 350001, Fujian Province, Peoples R China
2.Fujian Med Univ, Hepatobiliary Surg Inst, Union Clin Med Coll, Fuzhou 350001, Fujian Province, Peoples R China
3.Fujian Med Univ, Affiliated Union Hosp, Fuzhou 350001, Fujian Province, Peoples R China
4.Fujian Med Univ, Key Lab Gastrointestinal Canc, Minist Educ, Mol Med Res Ctr, Fuzhou 350001, Fujian Province, Peoples R China
5.Peking Univ, Shenzhen Hosp, Dept Pharm, Shenzhen, Peoples R China
6.Peking Univ, Dept Cell Biol, Sch Basic Med Sci, Beijing 100871, Peoples R China

Recommended Citation:
Zhang, G.,Liang, Y.,Huang, Y.,et al. Elevated Lysosome-associated Protein Transmembrane-4 beta-35 is an Independent Prognostic Marker in Pancreatic Carcinoma[J]. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,2012,40(4):1275-1283.
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